Search Results - "Ferrando‐May, Elisa"
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A practical guide to bioimaging research data management in core facilities
Published in Journal of microscopy (Oxford) (01-06-2024)“…Bioimage data are generated in diverse research fields throughout the life and biomedical sciences. Its potential for advancing scientific progress via modern,…”
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Deconvoluting gene and environment interactions to develop an “epigenetic score meter” of disease
Published in EMBO molecular medicine (11-09-2023)“…Human health is determined both by genetics (G) and environment (E). This is clearly illustrated in groups of individuals who are exposed to the same…”
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IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity
Published in Scientific reports (06-10-2015)“…Environmental signals can be translated into chromatin changes, which alter gene expression. Here we report a novel concept that cells can signal chromatin…”
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Poly(ADP‐ribose)‐mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function
Published in The FEBS journal (01-08-2014)“…Poly(ADP‐ribose) (PAR) is a complex and reversible post‐translational modification that controls protein function and localization through covalent…”
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A Joint Action in Times of Pandemic: The German BioImaging Recommendations for Operating Imaging Core Facilities During the SARS‐Cov‐2 Emergency
Published in Cytometry. Part A (01-09-2020)“…Operating shared resource laboratories (SRLs) in times of pandemic is a challenge for research institutions. In a multiuser, high‐turnover working space, the…”
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6
Two-stage dynamic DNA quality check by xeroderma pigmentosum group C protein
Published in The EMBO journal (19-08-2009)“…Xeroderma pigmentosum group C (XPC) protein initiates the DNA excision repair of helix‐distorting base lesions. To understand how this versatile subunit…”
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Advanced light microscopy core facilities: Balancing service, science and career
Published in Microscopy research and technique (01-06-2016)“…ABSTRACT Core Facilities (CF) for advanced light microscopy (ALM) have become indispensable support units for research in the life sciences. Their…”
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Real-Time Cellular Imaging of Protein Poly(ADP-ribos)ylation
Published in Angewandte Chemie International Edition (05-09-2016)“…Poly(ADP‐ribos)ylation (PARylation) is an important posttranslational protein modification, and is involved in major cellular processes such as gene regulation…”
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PARP1 catalytic variants reveal branching and chain length-specific functions of poly(ADP-ribose) in cellular physiology and stress response
Published in Nucleic acids research (09-10-2020)“…Abstract Poly(ADP-ribosyl)ation regulates numerous cellular processes like genome maintenance and cell death, thus providing protective functions but also…”
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10
Imaging-based study demonstrates how the DEK nanoscale distribution differentially correlates with epigenetic marks in a breast cancer model
Published in Scientific reports (07-08-2023)“…Epigenetic dysregulation of chromatin is one of the hallmarks of cancer development and progression, and it is continuously investigated as a potential general…”
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Hypophosphorylation of the architectural chromatin protein DEK in death-receptor-induced apoptosis revealed by the isotope coded protein label proteomic platform
Published in Proteomics (Weinheim) (01-11-2006)“…During apoptosis nuclear morphology changes dramatically due to alterations of chromatin architecture and cleavage of structural nuclear proteins. To…”
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Bacterial Growth Inhibition Screen (BGIS) identifies a loss‐of‐function mutant of the DEK oncogene, indicating DNA modulating activities of DEK in chromatin
Published in FEBS letters (01-05-2021)“…The DEK oncoprotein regulates cellular chromatin function via a number of protein–protein interactions. However, the biological relevance of its unique…”
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Recognising the importance and impact of Imaging Scientists: Global guidelines for establishing career paths within core facilities
Published in Journal of microscopy (Oxford) (01-06-2024)“…In the dynamic landscape of scientific research, imaging core facilities are vital hubs propelling collaboration and innovation at the technology development…”
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14
The oncoprotein DEK affects the outcome of PARP1/2 inhibition during mild replication stress
Published in PloS one (13-08-2019)“…DNA replication stress is a major source of genomic instability and is closely linked to tumor formation and progression. Poly(ADP-ribose)polymerases1/2…”
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Research data management for bioimaging: the 2021 NFDI4BIOIMAGE community survey [version 1; peer review: 2 approved]
Published in F1000 research (2022)“…Background Knowing the needs of the bioimaging community with respect to research data management (RDM) is essential for identifying measures that enable the…”
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16
Intercellular trafficking of the nuclear oncoprotein DEK
Published in Proceedings of the National Academy of Sciences - PNAS (23-04-2013)“…DEK is a biochemically distinct, conserved nonhistone protein that is vital to global heterochromatin integrity. In addition, DEK can be secreted and function…”
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DEK in the synovium of patients with juvenile idiopathic arthritis: Characterization of DEK antibodies and posttranslational modification of the DEK autoantigen
Published in Arthritis & rheumatology (Hoboken, N.J.) (01-02-2011)“…Objective DEK is a nuclear phosphoprotein and autoantigen in a subset of children with juvenile idiopathic arthritis (JIA). Autoantibodies to DEK are also…”
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Research data management for bioimaging: the 2021 NFDI4BIOIMAGE community survey [version 2; peer review: 2 approved]
Published in F1000 research (01-01-2022)“…Background Knowing the needs of the bioimaging community with respect to research data management (RDM) is essential for identifying measures that enable the…”
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19
Calcium-binding capacity of centrin2 is required for linear POC5 assembly but not for nucleotide excision repair
Published in PloS one (02-07-2013)“…Centrosomes, the principal microtubule-organising centres in animal cells, contain centrins, small, conserved calcium-binding proteins unique to eukaryotes…”
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Analysis of the cellular uptake and nuclear delivery of insulin-like growth factor binding protein-3 in human osteosarcoma cells
Published in International journal of cancer (01-04-2012)“…Insulin‐like growth factor (IGF) binding protein‐3 (IGFBP‐3) regulates cell proliferation and survival by extracellular interaction and inactivation of the…”
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