Search Results - "Feron, Lyman J. L"

Optimization of a Novel Binding Motif to (E)‑3-(3,5-Difluoro-4-((1R,3R)‑2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro‑1H‑pyrido[3,4‑b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist by De Savi, Chris, Bradbury, Robert H, Rabow, Alfred A, Norman, Richard A, de Almeida, Camila, Andrews, David M, Ballard, Peter, Buttar, David, Callis, Rowena J, Currie, Gordon S, Curwen, Jon O, Davies, Chris D, Donald, Craig S, Feron, Lyman J. L, Gingell, Helen, Glossop, Steven C, Hayter, Barry R, Hussain, Syeed, Karoutchi, Galith, Lamont, Scott G, MacFaul, Philip, Moss, Thomas A, Pearson, Stuart E, Tonge, Michael, Walker, Graeme E, Weir, Hazel M, Wilson, Zena

“…The discovery of an orally bioavailable selective estrogen receptor downregulator (SERD) with equivalent potency and preclinical pharmacology to the…”
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AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models by Weir, Hazel M, Bradbury, Robert H, Lawson, Mandy, Rabow, Alfred A, Buttar, David, Callis, Rowena J, Curwen, Jon O, de Almeida, Camila, Ballard, Peter, Hulse, Michael, Donald, Craig S, Feron, Lyman J L, Karoutchi, Galith, MacFaul, Philip, Moss, Thomas, Norman, Richard A, Pearson, Stuart E, Tonge, Michael, Davies, Gareth, Walker, Graeme E, Wilson, Zena, Rowlinson, Rachel, Powell, Steve, Sadler, Claire, Richmond, Graham, Ladd, Brendon, Pazolli, Ermira, Mazzola, Anne Marie, D'Cruz, Celina, De Savi, Chris

“…Fulvestrant is an estrogen receptor (ER) antagonist administered to breast cancer patients by monthly intramuscular injection. Given its present limitations of…”
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Optimization of a Novel Binding Motif to ( E )-3-(3,5-Difluoro-4-((1 R ,3 R )-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1 H -pyrido[3,4- b ]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist by De Savi, Chris, Bradbury, Robert H., Rabow, Alfred A., Norman, Richard A., de Almeida, Camila, Andrews, David M., Ballard, Peter, Buttar, David, Callis, Rowena J., Currie, Gordon S., Curwen, Jon O., Davies, Chris D., Donald, Craig S., Feron, Lyman J. L., Gingell, Helen, Glossop, Steven C., Hayter, Barry R., Hussain, Syeed, Karoutchi, Galith, Lamont, Scott G., MacFaul, Philip, Moss, Thomas A., Pearson, Stuart E., Tonge, Michael, Walker, Graeme E., Weir, Hazel M., Wilson, Zena

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