Search Results - "Fernie‐King, Barbara A."

Streptococcal inhibitor of complement (SIC) inhibits the membrane attack complex by preventing uptake of C567 onto cell membranes by Fernie‐King, Barbara A., Seilly, David J., Willers, Christine, Würzner, Reinhard, Davies, Alexandra, Lachmann, Peter J.

“…Summary Streptococcal inhibitor of complement (SIC) was first described in 1996 as a putative inhibitor of the membrane attack complex of complement (MAC). SIC…”
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Streptococcal Inhibitor of Complement Inhibits Two Additional Components of the Mucosal Innate Immune System: Secretory Leukocyte Proteinase Inhibitor and Lysozyme by FERNIE-KING, Barbara A, SEILLY, David J, DAVIES, Alexandra, LACHMANN, Peter J

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The interaction of streptococcal inhibitor of complement (SIC) and its proteolytic fragments with the human beta defensins by Fernie‐King, Barbara A., Seilly, David J., Lachmann, Peter J.

“…Summary Streptococcal inhibitor of complement (SIC) is a 31 kDa extracellular protein produced by a few highly virulent strains of Streptococcus pyogenes (in…”
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Attribution of the Various Inhibitory Actions of the Streptococcal Inhibitor of Complement (SIC) to Regions within the Molecule by Binks, Michael J., Fernie-King, Barbara A., Seilly, David J., Lachmann, Peter J., Sriprakash, Kadaba S.

“…Some strains of Streptococcus pyogenes secrete a virulence factor called the streptococcal inhibitor of complement (SIC) function. SIC is a polyfunctional…”
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Streptococcal DRS (distantly related to SIC) and SIC inhibit antimicrobial peptides, components of mucosal innate immunity: a comparison of their activities by Fernie-King, Barbara A., Seilly, David J., Binks, Michael J., Sriprakash, Kadaba S., Lachmann, Peter J.

“…“Streptococcal inhibitor of complement” (SIC) and “distantly related to SIC” (DRS) are related virulence factors secreted by M1 and M12 strains of GAS,…”
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Functional characterization of DRS from Streptococcus pyogenes M12 and M55 serotypes by Binks, Michael J., Fernie-King, Barbara A., Seilly, David J., Lachmann, Peter J., Sriprakash, Kadaba S.

“…The mature streptococcal secretary proteins, SIC and DRS, show similarity only in the proline-rich region (PRR). However, these proteins share some biological…”
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Mapping of functional domains of streptococcal inhibitor of complement (SIC) by Binks, Michael J., Fernie-King, Barbara A., Seilly, David J., Lachmann, Peter J., Sriprakash, Kadaba S.

“…We identified domains of SIC necessary for inhibiting complement function, for anti-beta-defensin activity and to bind ezrin. Interestingly the sic1 gene (from…”
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The membrane attack complex inhibitor of streptococcus pyogenes (SIC) binds preferentially to C567 by Fernie-King, Barbara A., Seilly, David J., Davies, Alexandra, Lachmann, Peter J.

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