Search Results - "Fernando, Setien"

SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade by Romero, Octavio A., Vilarrubi, Andrea, Alburquerque-Bejar, Juan J., Gomez, Antonio, Andrades, Alvaro, Trastulli, Deborah, Pros, Eva, Setien, Fernando, Verdura, Sara, Farré, Lourdes, Martín-Tejera, Juan F., Llabata, Paula, Oaknin, Ana, Saigi, Maria, Piulats, Josep M., Matias-Guiu, Xavier, Medina, Pedro P., Vidal, August, Villanueva, Alberto, Sanchez-Cespedes, Montse

“…Despite the genetic inactivation of SMARCA4 , a core component of the SWI/SNF-complex commonly found in cancer, there are no therapies that effectively target…”
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Distinct DNA methylomes of newborns and centenarians by Heyn, Holger, Li, Ning, Ferreira, Humberto J., Moran, Sebastian, Pisano, David G., Gomez, Antonio, Diez, Javier, Sanchez-Mut, Jose V., Setien, Fernando, Carmona, F. Javier, Puca, Annibale A., Sayols, Sergi, Pujana, Miguel A., Serra-Musach, Jordi, Iglesias-Platas, Isabel, Formiga, Francesc, Fernandez, Agustin F., Fraga, Mario F., Heath, Simon C., Valencia, Alfonso, Gut, Ivo G., Wang, Jun, Esteller, Manel

“…Human aging cannot be fully understood in terms of the constrained genetic setting. Epigenetic drift is an alternative means of explaining age-associated…”
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Whole-exome sequencing identifies MDH2 as a new familial paraganglioma gene by Cascón, Alberto, Comino-Méndez, Iñaki, Currás-Freixes, María, de Cubas, Aguirre A, Contreras, Laura, Richter, Susan, Peitzsch, Mirko, Mancikova, Veronika, Inglada-Pérez, Lucía, Pérez-Barrios, Andrés, Calatayud, María, Azriel, Sharona, Villar-Vicente, Rosa, Aller, Javier, Setién, Fernando, Moran, Sebastian, Garcia, Juan F, Río-Machín, Ana, Letón, Rocío, Gómez-Graña, Álvaro, Apellániz-Ruiz, María, Roncador, Giovanna, Esteller, Manel, Rodríguez-Antona, Cristina, Satrústegui, Jorgina, Eisenhofer, Graeme, Urioste, Miguel, Robledo, Mercedes

“…Disruption of the Krebs cycle is a hallmark of cancer. IDH1 and IDH2 mutations are found in many neoplasms, and germline alterations in SDH genes and FH…”
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BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors by Veeck, Jurgen, Ropero, Santiago, Setien, Fernando, Gonzalez-Suarez, Eva, Osorio, Ana, Benitez, Javier, Herman, James G, Esteller, Manel

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Epigenetic loss of the transfer RNA-modifying enzyme TYW2 induces ribosome frameshifts in colon cancer by Rosselló-Tortella, Margalida, Llinàs-Arias, Pere, Sakaguchi, Yuriko, Davalos, Veronica, Setien, Fernando, Calleja-Cervantes, Maria E., Pin˜eyro, David, Martínez-Gómez, Jesús, Guil, Sonia, Joshi, Ricky, Villanueva, Alberto, Suzuki, Tsutomu, Esteller, Manel

“…Transfer RNA (tRNA) activity is tightly regulated to provide a physiological protein translation, and tRNA chemical modifications control its function in a…”
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Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer by Palomeras, Sònia, Diaz-Lagares, Ángel, Viñas, Gemma, Setien, Fernando, Ferreira, Humberto J, Oliveras, Glòria, Crujeiras, Ana B, Hernández, Alejandro, Lum, David H, Welm, Alana L, Esteller, Manel, Puig, Teresa

“…Acquired resistance to trastuzumab is a major clinical problem in the treatment of HER2-positive (HER2+) breast cancer patients. The selection of…”
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Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing by Melo, Sonia, Villanueva, Alberto, Moutinho, Catia, Davalos, Veronica, Spizzo, Riccardo, Ivan, Cristina, Rossi, Simona, Setien, Fernando, Casanovas, Oriol, Simo-Riudalbas, Laia, Carmona, Javier, Carrere, Jordi, Vidal, August, Aytes, Alvaro, Puertas, Sara, Ropero, Santiago, Kalluri, Raghu, Croce, Carlo M, Calin, George A, Esteller, Manel

“…MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression at the posttranscriptional level and are critical for many cellular pathways. The…”
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Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma by Berdasco, María, Ropero, Santiago, Setien, Fernando, Fraga, Mario F, Lapunzina, Pablo, Losson, Régine, Alaminos, Miguel, Cheung, Nai-Kong, Rahman, Nazneen, Esteller, Manel

“…Sotos syndrome is an autosomal dominant condition characterized by overgrowth resulting in tall stature and macrocephaly, together with an increased risk of…”
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Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer by Ortiz-Barahona, Vanessa, Soler, Marta, Davalos, Veronica, García-Prieto, Carlos A, Janin, Maxime, Setien, Fernando, Fernández-Rebollo, Irene, Bech-Serra, Joan J, De La Torre, Carolina, Guil, Sonia, Villanueva, Alberto, Zhang, Pei-Hong, Yang, Li, Guarnacci, Marco, Schumann, Ulrike, Preiss, Thomas, Balaseviciute, Ugne, Montal, Robert, Llovet, Josep M, Esteller, Manel

“…RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggests that the epitranscriptome and its…”
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Epigenetic Differences Arise during the Lifetime of Monozygotic Twins by Fraga, Mario F., Ballestar, Esteban, Paz, Maria F., Ropero, Santiago, Setien, Fernando, Ballestar, Maria L., Heine-Suñer, Damia, Cigudosa, Juan C., Urioste, Miguel, Benitez, Javier, Boix-Chornet, Manuel, Sanchez-Aguilera, Abel, Ling, Charlotte, Carlsson, Emma, Poulsen, Pernille, Vaag, Allan, Stephan, Zarko, Spector, Tim D., Wu, Yue-Zhong, Plass, Christoph, Esteller, Manel, Gartler, Stanley M.

“…Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such…”
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In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma by Pérez-Salvia, Montserrat, Aldaba, Eneko, Vara, Yosu, Fabre, Myriam, Ferrer, Cristina, Masdeu, Carme, Zubia, Aizpea, Sebastian, Eider San, Otaegui, Dorleta, Llinàs-Arias, Pere, Rosselló-Tortella, Margalida, Berdasco, Maria, Moutinho, Catia, Setien, Fernando, Villanueva, Alberto, González-Barca, Eva, Muncunill, Josep, Navarro, José-Tomás, Piris, Miguel A, Cossio, Fernando P, Esteller, Manel

“…Cancer origin and development is associated not only with genetic alterations, but also with the disturbance of epigenetic profiles.1 In this regard, the…”
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KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer by Simó-Riudalbas, Laia, Pérez-Salvia, Montserrat, Setien, Fernando, Villanueva, Alberto, Moutinho, Catia, Martínez-Cardús, Anna, Moran, Sebastian, Berdasco, Maria, Gomez, Antonio, Vidal, Enrique, Soler, Marta, Heyn, Holger, Vaquero, Alejandro, de la Torre, Carolina, Barceló-Batllori, Silvia, Vidal, August, Roz, Luca, Pastorino, Ugo, Szakszon, Katalin, Borck, Guntram, Moura, Conceição S, Carneiro, Fátima, Zondervan, Ilse, Savola, Suvi, Iwakawa, Reika, Kohno, Takashi, Yokota, Jun, Esteller, Manel

“…Recent efforts to sequence human cancer genomes have highlighted that point mutations in genes involved in the epigenetic setting occur in tumor cells. Small…”
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Bromodomain inhibition shows antitumoral activity in mice and human luminal breast cancer by Pérez-Salvia, Montserrat, Simó-Riudalbas, Laia, Llinàs-Arias, Pere, Roa, Laura, Setien, Fernando, Soler, Marta, de Moura, Manuel Castro, Bradner, James E, Gonzalez-Suarez, Eva, Moutinho, Catia, Esteller, Manel

“…BET bromodomain inhibitors, which have an antitumoral effect against various solid cancer tumor types, have not been studied in detail in luminal breast…”
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DNA Methylomes Reveal Biological Networks Involved in Human Eye Development, Functions and Associated Disorders by Berdasco, María, Gómez, Antonio, Rubio, Marcos J., Català-Mora, Jaume, Zanón-Moreno, Vicente, Lopez, Miguel, Hernández, Cristina, Yoshida, Shigeo, Nakama, Takahito, Ishikawa, Keijiro, Ishibashi, Tatsuro, Boubekeur, Amina M., Louhibi, Lotfi, Pujana, Miguel A, Sayols, Sergi, Setien, Fernando, Corella, Dolores, de Torres, Carmen, Parareda, Andreu, Mora, Jaume, Zhao, Ling, Zhang, Kang, Lleonart, Matilde E., Alonso, Javier, Simó, Rafael, Caminal, Josep M., Esteller, Manel

“…This work provides a comprehensive CpG methylation landscape of the different layers of the human eye that unveils the gene networks associated with their…”
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Epigenetic Inactivation of the Premature Aging Werner Syndrome Gene in Human Cancer by Agrelo, Ruben, Cheng, Wen-Hsing, Setien, Fernando, Ropero, Santiago, Espada, Jesus, Fraga, Mario F., Herranz, Michel, Paz, Maria F., Sanchez-Cespedes, Montserrat, Artiga, Maria Jesus, Guerrero, David, Castells, Antoni, von Kobbe, Cayetano, Bohr, Vilhelm A., Esteller, Manel

“…Werner syndrome (WS) is an inherited disorder characterized by premature onset of aging, genomic instability, and increased cancer incidence. The disease is…”
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PB1705: THE HISTONE MODIFIER SETD6 IS EPIGENETICALLY REGULATED IN B‐CELL ACUTE LYMPHOBLASTIC LEUKEMIA AND INTERFERES WITH PROLIFERATION AND GENE EXPRESSION by Veselinova, Yoana, Campillo‐Marcos, Ignacio, Rossello‐Tortella, Margalida, Setien, Fernando, Ferrer, Gerardo, Esteller, Manel

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A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition by Esteller, Manel, Ropero, Santiago, Fraga, Mario F, Ballestar, Esteban, Hamelin, Richard, Yamamoto, Hiroyuki, Boix-Chornet, Manuel, Caballero, Rosalia, Alaminos, Miguel, Setien, Fernando, Paz, Maria F, Herranz, Michel, Palacios, Jose, Arango, Diego, Orntoft, Torben F, Aaltonen, Lauri A, Schwartz, Simó

“…Disruption of histone acetylation patterns is a common feature of cancer cells, but very little is known about its genetic basis. We have identified truncating…”
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A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancer by LOPEZ-SERRA, Lidia, BALLESTAR, Esteban, FRAGA, Mario F, ALAMINOS, Miguel, SETIEN, Fernando, ESTELLER, Manel

“…Methyl-CpG binding domain (MBD) proteins have been shown to couple DNA methylation to transcriptional repression. This biological property suggests a role for…”
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DNA Methylation Plasticity of Human Adipose-Derived Stem Cells in Lineage Commitment by Berdasco, María, Melguizo, Consolación, Prados, Jose, Gómez, Antonio, Alaminos, Miguel, Pujana, Miguel A, Lopez, Miguel, Setien, Fernando, Ortiz, Raul, Zafra, Inma, Aranega, Antonia, Esteller, Manel

“…Adult stem cells have an enormous potential for clinical use in regenerative medicine that avoids many of the drawbacks characteristic of embryonic stem cells…”
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The tumour suppressor and chromatin‐remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer by Romero, Octavio A., Setien, Fernando, John, Sam, Gimenez‐Xavier, Pol, Gómez‐López, Gonzalo, Pisano, David, Condom, Enric, Villanueva, Alberto, Hager, Gordon L., Sanchez‐Cespedes, Montse

“…BRG1, a member of the SWI/SNF complex, is mutated in cancer, but it is unclear how it promotes tumourigenesis. We report that re‐expression of BRG1 in lung…”
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