Search Results - "Fernando, Roshini"

Slit2 Modulates the Inflammatory Phenotype of Orbit-Infiltrating Fibrocytes in Graves' Disease by Fernando, Roshini, Grisolia, Ana Beatriz Diniz, Lu, Yan, Atkins, Stephen, Smith, Terry J

“…Human CD34 fibrocytes, circulating monocyte lineage progenitor cells, have recently been implicated in thyroid-associated ophthalmopathy (TAO), the ocular…”
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Thyrotropin regulates IL-6 expression in CD34+ fibrocytes: clear delineation of its cAMP-independent actions by Raychaudhuri, Nupur, Fernando, Roshini, Smith, Terry J

“…IL-6 plays diverse roles in normal and disease-associated immunity such as that associated with Graves' disease (GD). In that syndrome, the orbit undergoes…”
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Expression of Thyrotropin Receptor, Thyroglobulin, Sodium-Iodide Symporter, and Thyroperoxidase by Fibrocytes Depends on AIRE by Fernando, Roshini, Lu, Ying, Atkins, Stephen J, Mester, Tunde, Branham, Kari, Smith, Terry J

“…Context: CD34+ fibrocytes, bone marrow-derived progenitor cells, infiltrate orbital connective tissue in thyroid-associated ophthalmopathy, a manifestation of…”
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Human fibrocytes coexpress thyroglobulin and thyrotropin receptor by Fernando, Roshini, Atkins, Stephen, Raychaudhuri, Nupur, Lu, Ying, Li, Bin, Douglas, Raymond S, Smith, Terry J

“…Thyroglobulin (Tg) is the macromolecular precursor of thyroid hormones and is thought to be uniquely expressed by thyroid epithelial cells. Tg and the…”
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Intersection of Chemokine and TSH Receptor Pathways in Human Fibrocytes: Emergence of CXCL-12/CXCR4 Cross Talk Potentially Relevant to Thyroid-Associated Ophthalmopathy by Fernando, Roshini, Atkins, Stephen J, Smith, Terry J

“…Fibrocytes are monocyte progenitor cells that have been implicated in normal and pathological tissue remodeling. Among the prominent chemokine receptors…”
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Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis by Wubben, Thomas J, Chaudhury, Sraboni, Watch, Brennan T, Stuckey, Jeanne A, Weh, Eric, Fernando, Roshini, Goswami, Moloy, Pawar, Mercy, Rech, Jason C, Besirli, Cagri G

“…Treatment options are lacking to prevent photoreceptor death and subsequent vision loss. Previously, we demonstrated that reprogramming metabolism via the…”
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Metabolic Alterations Caused by Simultaneous Loss of HK2 and PKM2 Leads to Photoreceptor Dysfunction and Degeneration by Weh, Eric, Goswami, Moloy, Chaudhury, Sraboni, Fernando, Roshini, Miller, Nick, Hager, Heather, Sheskey, Sarah, Sharma, Vikram, Wubben, Thomas J, Besirli, Cagri G

“…HK2 and PKM2 are two main regulators of aerobic glycolysis. Photoreceptors (PRs) use aerobic glycolysis to produce the biomass necessary for the daily renewal…”
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Therapeutic IGF-I receptor inhibition alters fibrocyte immune phenotype in thyroid-associated ophthalmopathy by Fernando, Roshini, Caldera, Oshadi, Smith, Terry J.

“…Thyroid-associated ophthalmopathy (TAO) represents a disfiguring and potentially blinding autoimmune component of Graves’ disease. It appears to be driven, at…”
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Slit2 Regulates Hyaluronan & Cytokine Synthesis in Fibrocytes: Potential Relevance to Thyroid-Associated Ophthalmopathy by Fernando, Roshini, Smith, Terry J

“…Abstract Context CD34+ fibrocytes have been implicated in development of thyroid-associated ophthalmopathy (TAO), a consequential autoimmune manifestation of…”
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Teprotumumab Divergently Alters Fibrocyte Gene Expression: Implications for Thyroid-associated Ophthalmopathy by Fernando, Roshini, Smith, Terry J

“…Teprotumumab, an IGF-I receptor (IGF-IR) inhibitor, is effective in thyroid-associated ophthalmopathy (TAO). The drug can modulate induction by TSH of IL-6 and…”
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Slit2 May Underlie Divergent Induction by Thyrotropin of IL-23 and IL-12 in Human Fibrocytes by Fernando, Roshini, Atkins, Stephen J, Smith, Terry J

“…IL-23 and IL-12, two structurally related heterodimeric cytokines sharing a common subunit, divergently promote Th cell development and expansion. Both…”
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Flow cytometric method for the detection and quantification of retinal cell death and oxidative stress by Subramanya, Shubha, Fernando, Roshini, Goswami, Moloy, Besirli, Cagri G., Weh, Eric, Wubben, Thomas J.

“…Retinal cell death is the major cause of vision loss in many forms of blinding retinal disease. A plethora of research is focused on understanding the…”
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Response to Letter to the Editor: “Elevated Serum Tetrac in Graves Disease: Potential Pathogenic Role in Thyroid-Associated Ophthalmopathy” by Smith, Terry J, Scanlan, Thomas S, Fernando, Roshini

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CD34- Orbital Fibroblasts From Patients With Thyroid-Associated Ophthalmopathy Modulate TNF-α Expression in CD34+ Fibroblasts and Fibrocytes by Lu, Yan, Atkins, Stephen J, Fernando, Roshini, Trierweiler, Aaron, Mester, Tünde, Grisolia, Ana Beatriz Diniz, Mou, Pei, Novaes, Priscila, Smith, Terry J

“…Orbital fibroblasts from patients with Graves' disease (GD-OF) express many different cytokines when treated with bovine thyrotropin (bTSH). The present study…”
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Pentraxin-3 Is a TSH-Inducible Protein in Human Fibrocytes and Orbital Fibroblasts by Wang, Hao, Atkins, Stephen J, Fernando, Roshini, Wei, Rui-Li, Smith, Terry J

“…CD34+ fibrocytes are bone marrow–derived monocyte progenitor cells that traffic to sites of tissue injury and repair. They putatively infiltrate the orbit in…”
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Human Fibrocytes Express Multiple Antigens Associated With Autoimmune Endocrine Diseases by Fernando, Roshini, Vonberg, Andrew, Atkins, Stephen J, Pietropaolo, Susan, Pietropaolo, Massimo, Smith, Terry J

“…Context: Factors common to multiple autoimmune diseases have been sought vigorously. Graves' disease (GD) and type 1 diabetes mellitus (T1DM) involve end-organ…”
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Divergent Sp1 protein levels may underlie differential expression of UDP-glucose dehydrogenase by fibroblasts: role in susceptibility to orbital Graves disease by Tsui, Shanli, Fernando, Roshini, Chen, Beiling, Smith, Terry J

“…UDP-glucose dehydrogenase (UGDH) catalyzes the formation of UDP-glucuronate. Glucuronate represents an integral component of the glycosaminoglycan, hyaluronan,…”
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Disrupted TSH Receptor Expression in Female Mouse Lung Fibroblasts Alters Subcellular IGF-1 Receptor Distribution by Atkins, Stephen J, Lentz, Stephen I, Fernando, Roshini, Smith, Terry J

“…A relationship between the actions of TSH and IGF-1 was first recognized several decades ago. The close physical and functional associations between their…”
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Increased Expression of TSH Receptor by Fibrocytes in Thyroid-Associated Ophthalmopathy Leads to Chemokine Production by Gillespie, Erin F, Papageorgiou, Konstantinos I, Fernando, Roshini, Raychaudhuri, Nupur, Cockerham, Kimberly P, Charara, Laya K, Goncalves, Allan C. P, Zhao, Shuang-Xia, Ginter, Anna, Lu, Ying, Smith, Terry J, Douglas, Raymond S

“…Context: The molecular basis for anatomically dispersed clinical manifestations in Graves' disease (GD) eludes our understanding. Bone marrow-derived,…”
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Implementation of the WHO manual for Robson classification: an example from Sri Lanka using a local database for developing quality improvement recommendations by Senanayake, Hemantha, Piccoli, Monica, Valente, Emanuelle Pessa, Businelli, Caterina, Mohamed, Rishard, Fernando, Roshini, Sakalasuriya, Anshumalie, Ihsan, Fathima Reshma, Covi, Benedetta, Wanzira, Humphrey, Lazzerini, Marzia

“…ObjectivesThis study aimed at describing the use of a prospective database on hospital deliveries for analysing caesarean section (CS) practices according to…”
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