Search Results - "Fernando, Romaine Ingrid"
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Estradiol abrogates apoptosis in breast cancer cells through inactivation of BAD: Ras-dependent nongenomic pathways requiring signaling through ERK and Akt
Published in Molecular biology of the cell (01-07-2004)“…Estrogens such as 17-beta estradiol (E(2)) play a critical role in sporadic breast cancer progression and decrease apoptosis in breast cancer cells. Our…”
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Journal Article -
2
Striking efficacy of a vaccine targeting TOP2A for triple-negative breast cancer immunoprevention
Published in NPJ precision oncology (25-10-2023)“…Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that has a poor prognosis. TOP2A is a key enzyme in DNA replication and is a…”
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Journal Article -
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Abstract 647: Immunoprevention of triple negative breast cancer by a TOP2A multi-peptide vaccine
Published in Cancer research (Chicago, Ill.) (01-07-2019)“…Abstract Triple negative breast cancer (TNBC) comprises approximately 20% of all breast cancers, and it has a poor prognosis due to aggressive growth…”
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Journal Article -
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Development of a mesothelin-based prophylactic vaccine against ovarian cancer
Published in The Journal of immunology (1950) (01-05-2018)“…Abstract Mesothelin is a tumor-associated antigen overexpressed in ovarian cancer and normally expressed by mesothelial linings. While mesothelin function…”
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Journal Article -
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Estradiol Abrogates Apoptosis in Breast Cancer Cells through Inactivation of BAD: Ras-dependent Nongenomic Pathways Requiring Signaling through ERK and AktD
Published in Molecular biology of the cell (01-07-2004)“…Estrogens such as 17-β estradiol (E 2 ) play a critical role in sporadic breast cancer progression and decrease apoptosis in breast cancer cells. Our studies…”
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Journal Article -
6
BAD is a central player in cell death and cell cycle regulation in breast cancer cells
Published 01-01-2004“…The estrogen, 17-β estradiol (E2) can stimulate proliferation or induce differentiation or death depending on the cell context. In MCF 7 cells, an estrogen…”
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Dissertation