Search Results - "Fernando, Cossio"

Application of 1,3‐Dipolar Reactions between Azomethine Ylides and Alkenes to the Synthesis of Catalysts and Biologically Active Compounds by Arrastia, Iosune, Arrieta, Ana, Cossío, Fernando P.

“…The (3+2) cycloaddition between azomethine ylides and alkenes is an efficient, convergent and stereocontrolled method for the synthesis of unnatural…”
Get full text

Towards a more precise therapy in cancer: Exploring epigenetic complexity by Cossío, Fernando P., Esteller, Manel, Berdasco, María

“…A plethora of preclinical evidences suggests that pharmacological targeting of epigenetic dysregulation is a potent strategy to combat human diseases…”
Get full text

Alkenyl Arenes as Dipolarophiles in Catalytic Asymmetric 1,3-Dipolar Cycloaddition Reactions of Azomethine Ylides by Pascual-Escudero, Ana, de Cózar, Abel, Cossío, Fernando P., Adrio, Javier, Carretero, Juan C.

“…The use of alkenyl arenes as dipolarophiles in the catalytic asymmetric 1,3‐dipolar cycloaddition of azomethine ylides is reported. Under appropriate reaction…”
Get full text

Lanthanum‐Catalyzed Enantioselective Trifluoromethylation by Using an Electrophilic Hypervalent Iodine Reagent by Granados, Albert, Rivilla, Iván, Cossío, Fernando P., Vallribera, Adelina

“…A highly enantioselective catalytic method for the synthesis of quaternary α‐trifluoromethyl derivatives of 3‐oxo esters is described. The reaction uses…”
Get full text

Relevance of the DFT method to study expanded porphyrins with different topologies by Torrent‐Sucarrat, Miquel, Navarro, Sara, Cossío, Fernando P., Anglada, Josep M., Luis, Josep M.

“…Meso‐aryl expanded porphyrins present a structural versatility that allows them to achieve different topologies with distinct aromaticities. Several studies…”
Get full text

Aromaticity: Quo Vadis by Merino, Gabriel, Solà, Miquel, Fernández, Israel, Foroutan-Nejad, Cina, Lazzeretti, Paolo, Frenking, Gernot, Anderson, Harry L, Sundholm, Dage, Cossío, Fernando P, Petrukhina, Marina A, Wu, Jishan, Wu, Judy I, Restrepo, Albeiro

“…Aromaticity is one of the most deeply rooted concepts in chemistry. But why, if two-thirds of existing compounds can be classified as aromatic, is there no…”
Get full text

Organocatalysts Derived from Unnatural α‐Amino Acids: Scope and Applications by Agirre, Maddalen, Arrieta, Ana, Arrastia, Iosune, Cossío, Fernando P.

“…The organocatalytic properties of unnatural α‐amino acids are reviewed. Post‐translational derivatives of natural α‐amino acids include 4‐hydroxy‐l‐proline and…”
Get full text

Enantiopure [6]‐Azairidahelicene by Dynamic Kinetic Resolution of a Configurationally Labile [4]‐Helicene by Pazos, Ariadna, Cruz, Carlos M., Cuerva, Juan M., Rivilla, Ivan, Cossío, Fernando P., Freixa, Zoraida

“…A pair of enantiopure [6]‐azairidahelicenes incorporating chirality at the metal center and on the helicenic ligand were synthesized by dynamic kinetic…”
Get full text

Type-I Dyotropic Reactions: Understanding Trends in Barriers by Fernández, Israel, Bickelhaupt, F. Matthias, Cossío, Fernando P.

“…To understand the factors that control the activation barrier of type‐I 1,2‐dyotropic reactions (X‐EH2‐CH2‐X*→X*‐EH2‐CH2‐X, with E=C and Si, X=H, CH3, SiH3, F…”
Get full text

Ene-ene-yne Reactions: Activation Strain Analysis and the Role of Aromaticity by Fernández, Israel, Bickelhaupt, F. Matthias, Cossío, Fernando P.

“…The trend in reactivity of the thermal cycloisomerization reactions of 1,3‐hexadien‐5‐ynes, ABCDEF, were explored and analyzed by using density functional…”
Get full text

Cycloaddition of Butadiene with Perfluoroethylene: Prediction of a Periselectivity Switch under Pressure by Loukili, Mohammed, Rivilla, Ivan, Cossio, Fernando P., Cammi, Roberto, Chen, Bo

“…Defying the common Diels-Alder reactivity, the thermal cycloaddition between butadiene and tetrafluoroethylene (TFE) yields exclusively a [2 + 2] cycloadduct…”
Get full text

On the Role of the Solvent in the Synthesis of Spirocycles from Alkyne Cations Catalyzed by Triflic Acid: A DFT Study by Cózar, Abel, Arrieta, Ana, Cossío, Fernando P.

“…The relevance of solvent molecules in the reactivity of alkyne cations has been analyzed computationally. Analysis of the possible reaction mechanisms towards…”
Get full text

Selectivity in Cationic Cyclizations Involving Alkynes: A Computational Study on the Biomimetic Synthesis of Steroids by Cózar, Abel, Arrieta, Ana, Cossío, Fernando P.

“…Invited for the cover of this issue are Abel de Cózar, Ana Arrieta and Fernando P. Cossío at the University of the Basque Country. The image depicts the…”
Get full text

Selectivity in Cationic Cyclizations Involving Alkynes: A Computational Study on the Biomimetic Synthesis of Steroids by Cózar, Abel, Arrieta, Ana, Cossío, Fernando P.

“…Computational studies on the electrophilic cyclization between alkynes and transient carbocations or Lewis‐acid‐activated epoxides show that the regiochemistry…”
Get full text

Synthesis of a Stable Disilyne Bisphosphine Adduct and Its Non-Metal-Mediated CO₂ Reduction to CO by Gau, David, Rodriguez, Ricardo, Kato, Tsuyoshi, Saffon-Merceron, Nathalie, de Cózar, Abel, Cossío, Fernando P, Baceiredo, Antoine

“…Two P or not two P: The synthesis of the first stable disilyne bisphosphine adduct is reported. Its X‐ray structure, showing a short SiSi bond with a certain…”
Get full text

Fluorescent Imidazo[1,2‐a]pyrimidine Compounds as Biocompatible Organic Photosensitizers that Generate Singlet Oxygen: A Potential Tool for Phototheranostics by Lima, Maria L. S. O., Braga, Carolyne B., Becher, Tiago B., Odriozola‐Gimeno, Mikel, Torrent‐Sucarrat, Miquel, Rivilla, Iván, Cossío, Fernando P., Marsaioli, Anita J., Ornelas, Catia

“…Photodynamic therapy has been used to treat a variety of diseases, however, there is continuing search for new biocompatible photosensitizers. Herein, we…”
Get full text

A Three‐Component Enantioselective Cyclization Reaction Catalyzed by an Unnatural Amino Acid Derivative by de Gracia Retamosa, María, Ruiz‐Olalla, Andrea, Bello, Tamara, de Cózar, Abel, Cossío, Fernando P.

“…A new diastereo‐ and enantioselective three‐component cyclization reaction is described. The reaction takes place between a ketone, a carboxylic acid, and a…”
Get full text

Two‐State Reactivity of Histone Demethylases Containing Jumonji‐C Active Sites: Different Mechanisms for Different Methylation Degrees by Alberro, Nerea, Torrent‐Sucarrat, Miquel, Arrastia, Iosune, Arrieta, Ana, Cossío, Fernando P.

“…The N‐demethylation reactions of N,N,N‐trimethylpropan‐1‐ammonium and N,N‐dimethyl‐ and N‐methylpropan‐1‐aminium cations in the presence of…”
Get full text

Interplay between aromaticity and strain in double group transfer reactions to 1,2-benzyne by Fernández, Israel, Cossío, Fernando P.

“…Density Functional Theory calculations are used to explore the double hydrogen atom transfer from different alkanes to 1,2‐benzyne. State‐of‐the‐art…”
Get full text

Synthesis of Sultones from Chlorosulfates by a Complex Cascade Reaction Occurring under Mild Thermal Conditions by Cala, Lara, Rivilla, Iván, Cossío, Fernando P., Fañanás, Francisco J., Rodríguez, Félix

“…Chlorosulfate derivatives are interesting reagents that have been traditionally used to get other sulfur‐containing compounds by formal nucleophilic…”
Get full text