Search Results - "Fernandez Garcia, Meilin"

Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming by Soufi, Abdenour, Garcia, Meilin Fernandez, Jaroszewicz, Artur, Osman, Nebiyu, Pellegrini, Matteo, Zaret, Kenneth S

“…Pioneer transcription factors (TFs) access silent chromatin and initiate cell-fate changes, using diverse types of DNA binding domains (DBDs). FoxA, the…”
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LEAFY is a pioneer transcription factor and licenses cell reprogramming to floral fate by Jin, Run, Klasfeld, Samantha, Zhu, Yang, Fernandez Garcia, Meilin, Xiao, Jun, Han, Soon-Ki, Konkol, Adam, Wagner, Doris

“…Master transcription factors reprogram cell fate in multicellular eukaryotes. Pioneer transcription factors have prominent roles in this process because of…”
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Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation by McDaniel, Stephen L., Gibson, Tyler J., Schulz, Katharine N., Fernandez Garcia, Meilin, Nevil, Markus, Jain, Siddhant U., Lewis, Peter W., Zaret, Kenneth S., Harrison, Melissa M.

“…Reprogramming cell fate during the first stages of embryogenesis requires that transcriptional activators gain access to the genome and remodel the zygotic…”
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Haploinsufficiency of POU4F1 causes an ataxia syndrome with hypotonia and intention tremor by Webb, Bryn D., Evans, Anthony, Naidich, Thomas P., Bird, Lynne, Parikh, Sumit, Fernandez Garcia, Meilin, Henderson, Lindsay B., Millan, Francisca, Si, Yue, Brennand, Kristen J., Hung, Peter, Rucker, Janet C., Wheeler, Patricia G., Schadt, Eric E.

“…De novo, heterozygous, loss‐of‐function variants were identified in Pou domain, class 4, transcription factor 1 (POU4F1) via whole‐exome sequencing in four…”
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Structural Features of Transcription Factors Associating with Nucleosome Binding by Fernandez Garcia, Meilin, Moore, Cedric D., Schulz, Katharine N., Alberto, Oscar, Donague, Greg, Harrison, Melissa M., Zhu, Heng, Zaret, Kenneth S.

“…Fate-changing transcription factors (TFs) scan chromatin to initiate new genetic programs during cell differentiation and reprogramming. Yet the protein…”
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A pioneer factor locally opens compacted chromatin to enable targeted ATP-dependent nucleosome remodeling by Frederick, Megan A., Williamson, Kaylyn E., Fernandez Garcia, Meilin, Ferretti, Max B., McCarthy, Ryan L., Donahue, Greg, Luzete Monteiro, Edgar, Takenaka, Naomi, Reynaga, Janice, Kadoch, Cigall, Zaret, Kenneth S.

“…To determine how different pioneer transcription factors form a targeted, accessible nucleosome within compacted chromatin and collaborate with an…”
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Cis and trans determinants of epigenetic silencing by Polycomb repressive complex 2 in Arabidopsis by Xiao, Jun, Jin, Run, Yu, Xiang, Shen, Max, Wagner, John D, Pai, Armaan, Song, Claire, Zhuang, Michael, Klasfeld, Samantha, He, Chongsheng, Santos, Alexandre M, Helliwell, Chris, Pruneda-Paz, Jose L, Kay, Steve A, Lin, Xiaowei, Cui, Sujuan, Garcia, Meilin Fernandez, Clarenz, Oliver, Goodrich, Justin, Zhang, Xiaoyu, Austin, Ryan S, Bonasio, Roberto, Wagner, Doris

“…Doris Wagner and colleagues define Polycomb response elements (PREs) that direct the placement of Polycomb repressive complex 2 (PRC2) at developmental genes…”
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Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection by Dobrindt, Kristina, Hoagland, Daisy A., Seah, Carina, Kassim, Bibi, O'Shea, Callan P., Murphy, Aleta, Iskhakova, Marina, Fernando, Michael B., Powell, Samuel K., Deans, P.J. Michael, Javidfar, Ben, Peter, Cyril, Møller, Rasmus, Uhl, Skyler A., Garcia, Meilin Fernandez, Kimura, Masaki, Iwasawa, Kentaro, Crary, John F., Kotton, Darrell N., Takebe, Takanori, Huckins, Laura M., tenOever, Benjamin R., Akbarian, Schahram, Brennand, Kristen J.

“…The host response to SARS-CoV-2, the etiologic agent of the COVID-19 pandemic, demonstrates significant interindividual variability. In addition to showing…”
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Using the dCas9-KRAB system to repress gene expression in hiPSC-derived NGN2 neurons by Li, Aiqun, Cartwright, Samuel, Yu, Alex, Ho, Seok-Man, Schrode, Nadine, Deans, P.J. Michael, Matos, Marliette R., Garcia, Meilin Fernandez, Townsley, Kayla G., Zhang, Bin, Brennand, Kristen J.

“…We describe a CRISPR inhibition (CRISPRi) protocol to repress endogenous gene expression (e.g., ATP6V1A) in human induced pluripotent stem cell-derived…”
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MASSIVELY PARALLEL CHARACTERIZATION OF CONTEXT SPECIFIC REGULATORY RISK ELEMENTS ACROSS PSYCHIATRIC DISORDERS IN HUMAN-INDUCED PLURIPOTENT STEM CELL-DERIVED GLUTAMATERGIC NEURONS by Townsley, Kayla, Sen, Annabel, Lee, Jasmine, Deans, PJ Michael, Jia, Meng, Fernandez-Garcia, Meilin, Cartwright, Sam, Cohen, Sophie, Goate, Alison, Brennand, Kristen, Huckins, Laura

“…There is an urgent need to decipher the complex polygenic risk architecture of neuropsychiatric and neurodevelopmental disorders. Most disorder-associated…”
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The functional and evolutionary impacts of human-specific deletions in conserved elements by Xue, James R, Mackay-Smith, Ava, Mouri, Kousuke, Garcia, Meilin Fernandez, Dong, Michael X, Akers, Jared F, Noble, Mark, Li, Xue, Lindblad-Toh, Kerstin, Karlsson, Elinor K, Noonan, James P, Capellini, Terence D, Brennand, Kristen J, Tewhey, Ryan, Sabeti, Pardis C, Reilly, Steven K

“…Conserved genomic sequences disrupted in humans may underlie uniquely human phenotypic traits. We identified and characterized 10,032 human-specific conserved…”
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FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity by Reizel, Yitzhak, Morgan, Ashleigh, Gao, Long, Schug, Jonathan, Mukherjee, Sarmistha, García, Meilín Fernández, Donahue, Greg, Baur, Joseph A., Zaret, Kenneth S., Kaestner, Klaus H.

“…Tissue-specific DNA methylation patterns are created by transcription factors that recruit methylation and demethylation enzymes to cis-regulatory elements. To…”
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Mechanism of Nucleosome Targeting by Pioneer Transcription Factors by Fernández Garcia, Meilin M

“…Transcription factors (TFs) forage the genome to instruct cell plasticity, identity, and differentiation. These developmental processes are elicited through TF…”
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FoxA-dependent DNA demethylation initiates epigenetic control of cellular stability by Reizel, Yitzhak, Morgan, Ashleigh, Gao, Long, Schug, Jonathan, Mukherjee, Sarmistha, Fernández García, Meilín M., Donahue, Greg, Baur, Joseph A., Zaret, Kenneth S, Kaestner, Klaus H

“…Tissue-specific DNA methylation patterns at enhancers help to demarcate cellular identity. These DNA methylation patterns are created by transcription factors…”
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