Search Results - "Fernandez Abad, Maria"
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OMIP‐087: Thirty‐two parameter mass cytometry panel to assess human CD4 and CD8 T cell activation, memory subsets, and helper subsets
Published in Cytometry. Part A (01-03-2023)“…We developed a highly reproducible 32‐marker mass cytometry panel able to measure all canonical immune lineages and perform detailed characterization of both…”
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Precision mouse models with expanded tropism for human pathogens
Published in Nature biotechnology (01-10-2019)“…A major limitation of current humanized mouse models is that they primarily enable the analysis of human-specific pathogens that infect hematopoietic cells…”
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Trastuzumab deruxtecan in patients with central nervous system involvement from HER2-positive breast cancer: The DEBBRAH trial
Published in Neuro-oncology (Charlottesville, Va.) (05-01-2023)“…Trastuzumab deruxtecan (T-DXd) has shown durable antitumor activity in pretreated patients with HER2-positive advanced breast cancer (ABC), but its efficacy…”
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Potent Cell-Cycle Inhibition and Upregulation of Immune Response with Abemaciclib and Anastrozole in neoMONARCH, Phase II Neoadjuvant Study in HR + /HER2 - Breast Cancer
Published in Clinical cancer research (01-02-2020)“…neoMONARCH assessed the biological effects of abemaciclib in combination with anastrozole in the neoadjuvant setting. Postmenopausal women with stage I-IIIB HR…”
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Optimal [ 18 F]FDG PET/CT Cutoff for Pathologic Complete Response in HER2-Positive Early Breast Cancer Patients Treated with Neoadjuvant Trastuzumab and Pertuzumab in the PHERGain Trial
Published in Journal of Nuclear Medicine (01-05-2024)“…The PHERGain trial investigated the potential of metabolic imaging to identify candidates for chemotherapy deescalation in human epidermal growth factor…”
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The CD4/CD8 ratio in HIV-infected subjects is independently associated with T-cell activation despite long-term viral suppression
Published in The Journal of infection (01-01-2013)“…Summary Objectives HIV-infected subjects on antiretroviral therapy often fail to normalize the CD4/CD8 ratio despite CD4 count normalization. We aimed to…”
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Olaparib plus trastuzumab in HER2-positive advanced breast cancer patients with germline BRCA1/2 mutations: The OPHELIA phase 2 study
Published in Breast (Edinburgh) (01-10-2024)“…To evaluate the efficacy and safety of the combination of olaparib plus trastuzumab in patients with HER2-positive advanced breast cancer (ABC) and germinal…”
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Corrigendum: Reliable estimation of CD8 T cell inhibition of in vitro HIV-1 replication
Published in Frontiers in immunology (03-01-2023)“…[This corrects the article DOI: 10.3389/fimmu.2021.666991.]…”
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Reliable Estimation of CD8 T Cell Inhibition of In Vitro HIV-1 Replication
Published in Frontiers in immunology (30-06-2021)“…The HIV-1 viral inhibition assay (VIA) measures CD8 T cell-mediated inhibition of HIV replication in CD4 T cells and is increasingly used for clinical testing…”
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HIV-Specific T Cell Responses Are Highly Stable on Antiretroviral Therapy
Published in Molecular therapy. Methods & clinical development (13-12-2019)“…HIV infection induces a robust T cell response that is sustained by high viremia, but falls following the onset of antiretroviral therapy (ART). Relatively…”
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Molecular effects of lapatinib in patients with HER2 positive ductal carcinoma in situ
Published in Breast cancer research : BCR (04-09-2014)“…Human epidermal growth factor receptor 2 (HER2) amplification is frequent in ductal carcinoma in situ (DCIS) of the breast and is associated with poorly…”
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CD8 T Cell Virus Inhibition Assay Protocol
Published in Bio-protocol (20-03-2022)“…The human immunodeficiency virus (HIV)-1 viral inhibition assay (VIA) measures CD8 T cell-mediated inhibition of HIV replication in CD4 T cells and is…”
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Concluding Remarks for Special Issue HTLV-HIV Co-Infections
Published in Viruses (01-04-2023)“…During the early 1980s, the first 3 human retroviruses were identified: human T-lymphotropic virus 1 and 2 (HTLV-1 and HTLV-2) and human immunodeficiency virus…”
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Human cytomegalovirus-vectored vaccines against HIV
Published in Current opinion in HIV & AIDS (01-03-2019)“…PURPOSE OF REVIEWCMV-vectored vaccines expressing SIV antigens have mediated unprecedented levels of virus control following SIV challenge in rhesus macaques…”
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Brief Report: Toll-like Receptor 9-1635A/G Polymorphism Is Associated With HIV-1 Rebound After Four Weeks of Interruption of Antiretroviral Therapy
Published in Journal of acquired immune deficiency syndromes (1999) (01-10-2020)“…OBJECTIVES:This study aims to analyze the association of the presence of common polymorphisms [single nucleotide polymorphisms (SNPs)] on Toll-like receptors…”
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Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo
Published in Journal of virology (15-06-2018)“…Current efforts toward human immunodeficiency virus (HIV) eradication include approaches to augment immune recognition and elimination of persistently infected…”
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The effect of intensification with raltegravir on the HIV-1 reservoir of latently infected memory CD4 T cells in suppressed patients
Published in AIDS (London) (24-09-2012)“…The stability of the reservoir of latently infected memory CD4 T-cells may be associated with continuous replenishment from residual HIV-1, not completely…”
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Maintained complete response to talazoparib in a BRCA-2 mutated metastatic luminal breast cancer: case report and review of literature
Published in Frontiers in oncology (05-05-2023)“…PARP inhibitors are progressively becoming a part of our therapeutic arsenal against BRCA-defective tumors, because of their capacity to induce synthetic…”
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HTLV-2 Enhances CD8 + T Cell-Mediated HIV-1 Inhibition and Reduces HIV-1 Integrated Proviral Load in People Living with HIV-1
Published in Viruses (01-11-2022)“…People living with HIV-1 and HTLV-2 concomitantly show slower CD4 T cell depletion and AIDS progression, more frequency of the natural control of HIV-1, and…”
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Conserved-region MVA vaccines can shift HIV T cell immunodominance in PWH on ART - the M&M Study
Published in The Journal of immunology (1950) (01-05-2022)“…CD8+ T cell immunity is essential to the control of HIV viremia. We examined the safety and immunogenicity of MVA-vectored vaccines expressing highly conserved…”
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