Search Results - "Fernandez‐Santamaria, Ruben"

Engineered IL‐10: A matter of affinity by Fernandez‐Santamaria, Ruben, Satitsuksanoa, Pattraporn

“…Pleiotropic roles of IL‐10. Immune cells including regulatory T cells and B cells, ILCregs, macrophages, and DCs produce IL‐10, which exerts both…”
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Advances and highlights in biomarkers of allergic diseases by Ogulur, Ismail, Pat, Yagiz, Ardicli, Ozge, Barletta, Elena, Cevhertas, Lacin, Fernandez‐Santamaria, Ruben, Huang, Mengting, Bel Imam, Manal, Koch, Jana, Ma, Siyuan, Maurer, Debbie J., Mitamura, Yasutaka, Peng, Yaqi, Radzikowska, Urszula, Rinaldi, Arturo O., Rodriguez‐Coira, Juan, Satitsuksanoa, Pattraporn, Schneider, Stephan R., Wallimann, Alexandra, Zhakparov, Damir, Ziadlou, Reihane, Brüggen, Marie‐Charlotte, Veen, Willem, Sokolowska, Milena, Baerenfaller, Katja, Zhang, Luo, Akdis, Mubeccel, Akdis, Cezmi A.

“…During the past years, there has been a global outbreak of allergic diseases, presenting a considerable medical and socioeconomical burden. A large fraction of…”
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A compilation answering 50 questions on monkeypox virus and the current monkeypox outbreak by Cabanillas, Beatriz, Murdaca, Giuseppe, Guemari, Amir, Torres, Maria Jose, Azkur, Ahmet Kursat, Aksoy, Emel, Vitte, Joana, de las Vecillas, Leticia, Giovannini, Mattia, Fernández‐Santamaria, Ruben, Castagnoli, Riccardo, Orsi, Andrea, Amato, Rosa, Giberti, Irene, Català, Alba, Ambrozej, Dominika, Schaub, Bianca, Tramper‐Stranders, Gerdien A., Novak, Natalija, Nadeau, Kari C., Agache, Ioana, Akdis, Mubeccel, Akdis, Cezmi A.

“…The current monkeypox disease (MPX) outbreak constitutes a new threat and challenge for our society. With more than 55,000 confirmed cases in 103 countries,…”
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Genomic variants association with selective hypersensitivity reactions to amoxicillin and clavulanic acid by Nuñez, Rafael, Fernandez-Santamaria, Rubén, Salas, Maria, Bogas, Gador, Diez-Echave, Patricia, Mayorga, Cristobalina, Torres, Maria Jose, Fernandez, Tahia Diana

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Editorial comment on “The basophil activation test has high reproducibility and is feasible in the clinical setting” by Fernandez‐Santamaria, Ruben, Riggioni, Carmen, Peters, Rachel L.

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Coexistence of nasal reactivity to allergens with and without IgE sensitization in patients with allergic rhinitis by Eguiluz‐Gracia, Ibon, Fernandez‐Santamaria, Ruben, Testera‐Montes, Almudena, Ariza, Adriana, Campo, Paloma, Prieto, Ana, Perez‐Sanchez, Natalia, Salas, Maria, Mayorga, Cristobalina, Torres, Maria Jose, Rondon, Carmen

“…Background Allergic rhinitis (AR) and local allergic rhinitis (LAR) are defined by nasal reactivity to aeroallergens with and without positive skin prick test…”
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Advances and highlights in T and B cell responses to drug antigens by Fernandez‐Santamaria, Ruben, Ariza, Adriana, Fernandez, Tahia D., Cespedes, José A, Labella, Marina, Mayorga, Cristobalina, Torres, María J

“…The immunological mechanisms involved in drug hypersensitivity reactions (DHRs) are complex, and despite important advances, multiple aspects remain poorly…”
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Dendritic cells inclusion and cell‐subset assessment improve flow‐cytometry‐based proliferation test in non‐immediate drug hypersensitivity reactions by Fernandez‐Santamaria, Ruben, Bogas, Gador, Palomares, Francisca, Salas, Maria, Fernandez, Tahia D., Jimenez, Isabel, Barrionuevo, Esther, Doña, Inmaculada, Torres, Maria Jose, Mayorga, Cristobalina

“…Background Lymphocyte transformation test (LTT) has been widely used to evaluate non‐immediate drug hypersensitivity reactions (NIDHRs). However, the lack of…”
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Identification of an antigenic determinant of clavulanic acid responsible for IgE‐mediated reactions by Barbero, Nekane, Fernández‐Santamaría, Rubén, Mayorga, Cristobalina, Martin‐Serrano, Ángela, Salas, María, Bogas, Gador, Nájera, Francisco, Pérez‐Sala, Dolores, Pérez‐Inestrosa, Ezequiel, Fernandez, Tahia D., Montañez, María I., Torres, María J.

“…Background Selective reactions to clavulanic acid (CLV) account for around 30% of immediate reactions after administration of amoxicillin‐CLV. Currently, no…”
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Sequential class switch recombination to IgE and allergen‐induced accumulation of IgE+ plasmablasts occur in the nasal mucosa of local allergic rhinitis patients by Testera‐Montes, Almudena, Palomares, Francisca, Jurado‐Escobar, Raquel, Fernandez‐Santamaria, Ruben, Ariza, Adriana, Verge, Jesus, Salas, Maria, Campo, Paloma, Mayorga, Cristobalina, Torres, Maria Jose, Rondon, Carmen, Eguiluz‐Gracia, Ibon

“…Background The involvement of allergen‐specific (s)IgE in local allergic rhinitis (LAR) has been debated. Here, we investigate the effect of nasal allergen…”
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Synthetic antigenic determinants of clavulanic acid induce dendritic cell maturation and specific T cell proliferation in patients with immediate hypersensitivity reactions by Fernandez‐Santamaria, Ruben, Bogas, Gador, Montañez, Maria Isabel, Ariza, Adriana, Salas, Maria, Cespedes, Jose Antonio, Labella, Marina, Paris, Juan Luis, Perez‐Sanchez, Natalia, Perez‐Inestrosa, Ezequiel, Vida, Yolanda, Fernandez, Tahia D., Mayorga, Cristobalina, Torres, Maria Jose

“…Background Immediate drug hypersensitivity reactions (IDHRs) to clavulanic acid (CLV) have increased in the last decades due to a higher consumption alongside…”
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Basophil activation test is a complementary tool in the diagnosis of immediate reactions to platinum salts and taxanes by Bogas, Gádor, Ariza, Adriana, Vázquez-Revuelta, Paula, Labella, Marina, Madrigal-Burgaleta, Ricardo, Fernández-Santamaría, Rubén, Calvo-Serrano, Silvia, Villar-Chamorro, Esther, Martín-Clavo, Susana, Lebrón-Martín, Clara, Mayorga, Cristobalina, Doña, Inmaculada, Torres, Maria J

“…Delabelling pathways offer confirmatory diagnosis and can prevent unnecessary second-line therapies or drug desensitization procedures after chemotherapeutic…”
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Clinical impact and immunological alterations in asthmatic patients allergic to grass pollen subjected to high urban pollution in Madrid by Feo‐Brito, Francisco, Alfaya Arias, Teresa, Amo‐Salas, Mariano, Somoza Álvarez, María Luisa, Haroun Díaz, Elisa, Mayorga Mayorga, Cristobalina, Fernández Santamaría, Rubén, Urra Ardanaz, José Miguel

“…Background The prevalence of asthma has increased in recent decades. Among the reasons for this increase is environmental pollution. Pollutants cause bronchial…”
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Use of the Basophil Activation Test May Reduce the Need for Drug Provocation in Amoxicillin-Clavulanic Allergy by Salas, María, Fernández-Santamaría, Rubén, Mayorga, Cristobalina, Barrionuevo, Esther, Ariza, Adriana, Posadas, Teresa, Laguna, Jose Julio, Montañez, María Isabel, Molina, Noemi, Fernández, Tahia Diana, Torres, María José

“…Reports of selective reactions to clavulanic acid (CLV) have increased in recent decades because of its increased prescription in combination with amoxicillin…”
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New Approaches for Basophil Activation Tests Employing Dendrimeric Antigen-Silica Nanoparticle Composites by Calvo-Serrano, Silvia, Matamoros, Esther, Céspedes, Jose Antonio, Fernández-Santamaría, Rubén, Gil-Ocaña, Violeta, Perez-Inestrosa, Ezequiel, Frecha, Cecilia, Montañez, Maria I, Vida, Yolanda, Mayorga, Cristobalina, Torres, Maria J

“…In vitro cell activation through specific IgE bound to high-affinity receptors on the basophil surface is a widely used strategy for the evaluation of…”
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Patients Taking Amoxicillin-Clavulanic Can Become Simultaneously Sensitized to Both Drugs by Salas, María, MD, PhD, Laguna, Jose Julio, MD, Doña, Inmaculada, MD, PhD, Barrionuevo, Esther, MD, PhD, Fernandez-Santamaría, Rubén, BSc, Ariza, Adriana, PhD, Perez-Inestrosa, Ezequiel, PhD, Mayorga, Cristobalina, PhD, Fernández, Tahia Diana, PhD, Torres, María José, MD, PhD

“…Background Patients can react to amoxicillin (AX) and clavulanic acid (CLV) taken in combination because of selective reactions to either drug. However, scant…”
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Penicillin and cephalosporin cross‐reactivity: role of side chain and synthetic cefadroxil epitopes by Bogas, Gador, Mayorga, Cristobalina, Martín‐Serrano, Ángela, Fernández‐Santamaría, Rubén, Jiménez‐Sánchez, Isabel M., Ariza, Adriana, Barrionuevo, Esther, Posadas, Teresa, Salas, María, Fernández, Tahía Diana, Torres, María José, Montañez, María Isabel

“…Background Analysis of cross‐reactivity is necessary for prescribing safe cephalosporins for penicillin allergic patients. Amoxicillin (AX) is the betalactam…”
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Epidemiology, Mechanisms, and Diagnosis of Drug-Induced Anaphylaxis by Montañez, Maria Isabel, Mayorga, Cristobalina, Bogas, Gador, Barrionuevo, Esther, Fernandez-Santamaria, Ruben, Martin-Serrano, Angela, Laguna, Jose Julio, Torres, Maria José, Fernandez, Tahia Diana, Doña, Inmaculada

“…Anaphylaxis is an acute, life-threatening, multisystem syndrome resulting from the sudden release of mediators by mast cells and basophils. Although…”
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Expression of the Tim3‐galectin‐9 axis is altered in drug‐induced maculopapular exanthema by Fernandez‐Santamaría, Ruben, Palomares, Francisca, Salas, Maria, Doña, Inmaculada, Bogas, Gador, Ariza, Adriana, Rodriguez‐Nogales, Alba, Plaza‐Seron, Maria C., Mayorga, Cristobalina, Torres, Maria J., Fernández, Tahia D.

“…Background Drug‐induced maculopapular exanthemas (MPEs) are mediated by Th1 CD4+ T cells. One of the mechanisms of control of Th1 cells in homeostasis is the…”
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The Basophil Activation Test Can Be of Value for Diagnosing Immediate Allergic Reactions to Omeprazole by Laguna, Jose J., Bogas, Gador, Salas, Maria, Mayorga, Cristobalina, Dionicio, Javier, Gonzalez-Mendiola, Rosario, Ariza, Adriana, Fernández-Santamaría, Ruben, Olazabal, Isabel, Doña, Inmaculada, Fernandez, Tahia D., Torres, Maria J.

“…Proton pump inhibitors (PPIs) are commonly used to treat gastrointestinal diseases. Incidence of hypersensitivity reactions to PPIs has risen, likely because…”
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