Search Results - "Fernandez‐Barrena, Maite G."

Sweet dreams could be made of this: carbohydrate‐responsive element‐binding protein (ChREBP) as a target for hepatocellular carcinoma therapy by Fernández‐Barrena, Maite G., Avila, Matías A.

“…Rewiring of cellular metabolism is now fully recognized as a hallmark of cancer. Tumor cells reprogram metabolic pathways to meet the energetic and…”
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MicroRNA‐506 promotes primary biliary cholangitis–like features in cholangiocytes and immune activation by Erice, Oihane, Munoz‐Garrido, Patricia, Vaquero, Javier, Perugorria, Maria J., Fernandez‐Barrena, Maite G., Saez, Elena, Santos‐Laso, Alvaro, Arbelaiz, Ander, Jimenez‐Agüero, Raul, Fernandez‐Irigoyen, Joaquin, Santamaria, Enrique, Torrano, Verónica, Carracedo, Arkaitz, Ananthanarayanan, Meenakshisundaram, Marzioni, Marco, Prieto, Jesus, Beuers, Ulrich, Oude Elferink, Ronald P., LaRusso, Nicholas F., Bujanda, Luis, Marin, Jose J.G., Banales, Jesus M.

“…Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease associated with autoimmune phenomena targeting intrahepatic bile duct cells…”
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Epigenetic Mechanisms in Gastric Cancer: Potential New Therapeutic Opportunities by Canale, Matteo, Casadei-Gardini, Andrea, Ulivi, Paola, Arechederra, Maria, Berasain, Carmen, Lollini, Pier-Luigi, Fernández-Barrena, Maite G, Avila, Matías A

“…Gastric cancer (GC) is one of the deadliest malignancies worldwide. Complex disease heterogeneity, late diagnosis, and suboptimal therapies result in the poor…”
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The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation by Recalde, Miriam, Gárate-Rascón, María, Elizalde, María, Azkona, María, Latasa, M Ujue, Bárcena-Varela, Marina, Sangro, Bruno, Fernández-Barrena, Maite G, Ávila, Matías A, Arechederra, María, Berasain, Carmen

“…Abstract Gene expression is finely and dynamically controlled through the tightly coordinated and interconnected activity of epigenetic modulators,…”
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Ileal FGF15 contributes to fibrosis‐associated hepatocellular carcinoma development by Uriarte, Iker, Latasa, M. Ujue, Carotti, Simone, Fernandez‐Barrena, Maite G., Garcia‐Irigoyen, Oihane, Elizalde, Maria, Urtasun, Raquel, Vespasiani‐Gentilucci, Umberto, Morini, Sergio, Mingo, Alvaro, Mari, Montserrat, Corrales, Fernando J., Prieto, Jesus, Berasain, Carmen, Avila, Matias A.

“…Fibroblast growth factor 15 (FGF15), FGF19 in humans, is a gut‐derived hormone and a key regulator of bile acids and carbohydrate metabolism. FGF15 also…”
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SLU7: A New Hub of Gene Expression Regulation-From Epigenetics to Protein Stability in Health and Disease by Gárate-Rascón, María, Recalde, Miriam, Rojo, Carla, Fernández-Barrena, Maite G, Ávila, Matías A, Arechederra, María, Berasain, Carmen

“…SLU7 (Splicing factor synergistic lethal with U5 snRNA 7) was first identified as a splicing factor necessary for the correct selection of 3' splice sites,…”
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New molecular interactions of c‐Myc in cholangiocarcinoma may open new therapeutic opportunities by Berasain, Carmen, Fernández‐Barrena, Maite G., Avila, Matías A.

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Hepatic progenitor cells, senescence and IL-6 as the main players in combined hepatocellular-cholangiocarcinoma development by Arechederra, María, Fernández-Barrena, Maite G.

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Regulation of GLI Underlies a Role for BET Bromodomains in Pancreatic Cancer Growth and the Tumor Microenvironment by Huang, Yinshi, Nahar, Sabikun, Nakagawa, Akifumi, Fernandez-Barrena, Maite G, Mertz, Jennifer A, Bryant, Barbara M, Adams, Curtis E, Mino-Kenudson, Mari, Von Alt, Kate N, Chang, Kevin, Conery, Andrew R, Hatton, Charlie, Sims, 3rd, Robert J, Fernandez-Zapico, Martin E, Wang, Xingpeng, Lillemoe, Keith D, Fernández-Del Castillo, Carlos, Warshaw, Andrew L, Thayer, Sarah P, Liss, Andrew S

“…The initiation, progression, and maintenance of pancreatic ductal adenocarcinoma (PDAC) results from the interplay of genetic and epigenetic events. While the…”
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Loss of liver function in chronic liver disease: An identity crisis by Berasain, Carmen, Arechederra, Maria, Argemí, Josepmaria, Fernández-Barrena, Maite G., Avila, Matías A.

“…Adult hepatocyte identity is constructed throughout embryonic development and fine-tuned after birth. A multinodular network of transcription factors, along…”
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Epigenetic Mechanisms in Hepatic Stellate Cell Activation During Liver Fibrosis and Carcinogenesis by Barcena-Varela, Marina, Colyn, Leticia, Fernandez-Barrena, Maite G

“…Liver fibrosis is an essential component of chronic liver disease (CLD) and hepatocarcinogenesis. The fibrotic stroma is a consequence of sustained liver…”
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Epigenetics in hepatocellular carcinoma development and therapy: The tip of the iceberg by Fernández-Barrena, Maite G., Arechederra, María, Colyn, Leticia, Berasain, Carmen, Avila, Matias A.

“…Hepatocellular carcinoma (HCC) is a deadly tumour whose causative agents are generally well known, but whose pathogenesis remains poorly understood…”
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Next-generation sequencing of bile cell-free DNA for the early detection of patients with malignant biliary strictures by Arechederra, Maria, Rullán, María, Amat, Irene, Oyon, Daniel, Zabalza, Lucia, Elizalde, Maria, Latasa, M Ujue, Mercado, Maria R, Ruiz-Clavijo, David, Saldaña, Cristina, Fernández-Urién, Ignacio, Carrascosa, Juan, Jusué, Vanesa, Guerrero-Setas, David, Zazpe, Cruz, González-Borja, Iranzu, Sangro, Bruno, Herranz, Jose M, Purroy, Ana, Gil, Isabel, Nelson, Leonard J, Vila, Juan J, Krawczyk, Marcin, Zieniewicz, Krzysztof, Patkowski, Waldemar, Milkiewicz, Piotr, Cubero, Francisco Javier, Alkorta-Aranburu, Gorka, G Fernandez-Barrena, Maite, Urman, Jesus M, Berasain, Carmen, Avila, Matias A

“…Despite significant progresses in imaging and pathological evaluation, early differentiation between benign and malignant biliary strictures remains…”
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Epigenetic remodelling in human hepatocellular carcinoma by Braghini, Maria Rita, Lo Re, Oriana, Romito, Ilaria, Fernandez-Barrena, Maite G, Barbaro, Barbara, Pomella, Silvia, Rota, Rossella, Vinciguerra, Manlio, Avila, Matias A, Alisi, Anna

“…Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer, being the sixth most commonly diagnosed cancer and the fourth leading cause of…”
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Chromatin dynamics during liver regeneration by Arechederra, Maria, Berasain, Carmen, Avila, Matias A., Fernández-Barrena, Maite G.

“…[Display omitted] Liver regeneration is the most important reaction of the liver to an injury. Indeed, the liver possesses an extraordinary regenerative…”
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The TGF-β Pathway: A Pharmacological Target in Hepatocellular Carcinoma? by Gonzalez-Sanchez, Ester, Vaquero, Javier, Férnandez-Barrena, Maite G., Lasarte, Juan José, Avila, Matías A., Sarobe, Pablo, Reig, María, Calvo, Mariona, Fabregat, Isabel

“…Transforming Growth Factor-beta (TGF-β) superfamily members are essential for tissue homeostasis and consequently, dysregulation of their signaling pathways…”
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Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice by Uriarte, Iker, Fernandez-Barrena, Maite G, Monte, Maria J, Latasa, Maria U, Chang, Haisul C Y, Carotti, Simone, Vespasiani-Gentilucci, Umberto, Morini, Sergio, Vicente, Eva, Concepcion, Axel R, Medina, Juan F, Marin, José Juan G, Berasain, Carmen, Prieto, Jesus, Avila, Matías A

“…Cholestasis is associated with increased liver injury and morbidity after partial hepatectomy (PH), yet bile acids (BAs) are emerging as important mediators of…”
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IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis by Rajurkar, Mihir, Dang, Kyvan, Fernandez-Barrena, Maite G, Liu, Xiangfan, Fernandez-Zapico, Martin E, Lewis, Brian C, Mao, Junhao

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies lacking effective therapeutic strategies. Here, we show that the noncanonical…”
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Fragile X mental retardation protein in intrahepatic cholangiocarcinoma: regulating the cancer cell behavior plasticity at the leading edge by Carotti, Simone, Zingariello, Maria, Francesconi, Maria, D’Andrea, Laura, Latasa, M. Ujue, Colyn, Leticia, Fernandez-Barrena, Maite G., Flammia, Rocco Simone, Falchi, Mario, Righi, Daniela, Pedini, Giorgia, Pantano, Francesco, Bagni, Claudia, Perrone, Giuseppe, Rana, Rosa Alba, Avila, Matias A., Morini, Sergio, Zalfa, Francesca

“…Intrahepatic cholangiocarcinoma (iCCA) is a rare malignancy of the intrahepatic biliary tract with a very poor prognosis. Although some clinicopathological…”
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Comprehensive in silico CpG methylation analysis in hepatocellular carcinoma identifies tissue- and tumor-type specific marks disconnected from gene expression by Bilbao, Idoia, Recalde, Miriam, Daian, Fabrice, Herranz, José Maria, Elizalde, María, Iñarrairaegui, Mercedes, Canale, Matteo, Fernández-Barrena, Maite G, Casadei-Gardini, Andrea, Sangro, Bruno, Ávila, Matías A, Landecho Acha, Manuel F, Berasain, Carmen, Arechederra, María

“…DNA methylation is crucial for chromatin structure, transcription regulation and genome stability, defining cellular identity. Aberrant hypermethylation of…”
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