Search Results - "Fernandez, Thomas"

Efficient reconstruction of cell lineage trees for cell ancestry and cancer by Jang, Yeongjun, Fasching, Liana, Bae, Taejeong, Tomasini, Livia, Schreiner, Jeremy, Szekely, Anna, Fernandez, Thomas V, Leckman, James F, Vaccarino, Flora M, Abyzov, Alexej

“…Abstract Mosaic mutations can be used to track cell ancestries and reconstruct high-resolution lineage trees during cancer progression and during development,…”
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Improved cytosine base editors generated from TadA variants by Lam, Dieter K., Feliciano, Patricia R., Arif, Amena, Bohnuud, Tanggis, Fernandez, Thomas P., Gehrke, Jason M., Grayson, Phil, Lee, Kin D., Ortega, Manuel A., Sawyer, Courtney, Schwaegerle, Noah D., Peraro, Leila, Young, Lauren, Lee, Seung-Joo, Ciaramella, Giuseppe, Gaudelli, Nicole M.

“…Cytosine base editors (CBEs) enable programmable genomic C·G-to-T·A transition mutations and typically comprise a modified CRISPR–Cas enzyme, a naturally…”
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The genetics of trichotillomania and excoriation disorder: A systematic review by Reid, Madison, Lin, Ashley, Farhat, Luis C., Fernandez, Thomas V., Olfson, Emily

“…Trichotillomania (TTM) and excoriation disorder (ED) are impairing obsessive-compulsive related disorders that are common in the general population and for…”
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Early developmental asymmetries in cell lineage trees in living individuals by Fasching, Liana, Jang, Yeongjun, Tomasi, Simone, Schreiner, Jeremy, Tomasini, Livia, Brady, Melanie V, Bae, Taejeong, Sarangi, Vivekananda, Vasmatzis, Nikolaos, Wang, Yifan, Szekely, Anna, Fernandez, Thomas V, Leckman, James F, Abyzov, Alexej, Vaccarino, Flora M

“…Mosaic mutations can be used to track cell lineages in humans. We used cell cloning to analyze embryonic cell lineages in two living individuals and a…”
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4.1 New Genetic Findings in Tourette’s and Tic Disorders by Fernandez, Thomas V.

“…This presentation will provide an overview of the latest research findings and methodologies in genetic investigations of Tourette’s disorder (TD) and tic…”
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5.1 Gene Discovery in Neuropsychiatric Disorders by Fernandez, Thomas V.

“…The goal of this presentation will be to introduce the audience to methods of genetic discovery in childhood neuropsychiatric disorders. Recent studies in ASD,…”
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Whole‐exome DNA sequencing in childhood anxiety disorders identifies rare de novo damaging coding variants by Olfson, Emily, Lebowitz, Eli R., Hommel, Grace, Pashankar, Neha, Silverman, Wendy K., Fernandez, Thomas V.

“…Background Genetic factors contribute to the development of anxiety disorders, yet few risk genes have been previously identified. One genomic approach that…”
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Transcriptome Analysis of the Human Striatum in Tourette Syndrome by Lennington, Jessica B, Coppola, Gianfilippo, Kataoka-Sasaki, Yuko, Fernandez, Thomas V, Palejev, Dean, Li, Yifan, Huttner, Anita, Pletikos, Mihovil, Sestan, Nenad, Leckman, James F, Vaccarino, Flora M

“…Abstract Background Genome-wide association studies have not revealed any risk-conferring common genetic variants in Tourette syndrome (TS), requiring the…”
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Primary complex motor stereotypies are associated with de novo damaging DNA coding mutations that identify KDM5B as a risk gene by Fernandez, Thomas V, Williams, Zsanett P, Kline, Tina, Rajendran, Shreenath, Augustine, Farhan, Wright, Nicole, Sullivan, Catherine A W, Olfson, Emily, Abdallah, Sarah B, Liu, Wenzhong, Hoffman, Ellen J, Gupta, Abha R, Singer, Harvey S

“…Motor stereotypies are common in children with autism spectrum disorder (ASD), intellectual disability, or sensory deprivation, as well as in typically…”
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Protocol description for a randomized controlled trial of fMRI neurofeedback for tics in adolescents with Tourette Syndrome by Awasthi, Jitendra, Harris-Starling, Cheyenne, Kalvin, Carla, Pittman, Brian, Park, Haesoo, Bloch, Michael, Fernandez, Thomas V, Sukhodolsky, Denis G, Hampson, Michelle

“…This article describes the protocol for a randomized, controlled clinical trial of a neurofeedback (NF) intervention for Tourette Syndrome (TS) and chronic tic…”
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Genetic Insights Into ADHD Biology by Hayman, Victoria, Fernandez, Thomas V

“…ADHD is a neurobiological disorder with a large worldwide prevalence causing significant impairment in children, adolescents, and adults. While there is…”
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Characteristics of trichotillomania and excoriation disorder across the lifespan by Lin, Ashley, Farhat, Luis C., Flores, José M., Levine, Jessica L.S., Fernandez, Thomas V., Bloch, Michael H., Olfson, Emily

“…•Individuals with trichotillomania, excoriation disorder, and both conditions share many characteristics with high rates of co-occurring disorders.•Among…”
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What Makes You Tic? A New Lead in Tourette Syndrome Genetics by Fernandez, Thomas V

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A cellular perspective of bias at G protein‐coupled receptors by Fernandez, Thomas J., De Maria, Monica, Lobingier, Braden T.

“…G protein‐coupled receptors (GPCRs) modulate cell function over short‐ and long‐term timescales. GPCR signaling depends on biochemical parameters that define…”
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What is the optimal anesthetic monitoring regarding immediate and short‐term outcomes after liver transplantation?—A systematic review of the literature and expert panel recommendations by Fernandez, Thomas M.A., Schofield, Nick, Krenn, Claus G, Rizkalla, Nicole, Spiro, Michael, Raptis, Dimitri Aristotle, De Wolf, Andre M, Merritt, William T.

“…Background Liver transplant centers vary in approach to intraoperative vascular accesses, monitoring of cardiac function and temperature management. Evidence…”
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Motor Stereotypies: A Pathophysiological Review by Péter, Zsanett, Oliphant, Melody E, Fernandez, Thomas V

“…Motor stereotypies are common, repetitive, rhythmic movements with typical onset in early childhood. While most often described in children with autism…”
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Clinical characteristics of probands with obsessive-compulsive disorder from simplex and multiplex families by Lima, Monicke O, Saraiva, Leonardo C, Ramos, Vanessa R, Oliveira, Melaine C, Costa, Daniel L C, Fernandez, Thomas V, Crowley, James J, Storch, Eric A, Shavitt, Roseli G, Miguel, Euripedes C, Cappi, Carolina

“…•Multiplex and simplex families.•994 Brazilian probands with OCD.•Multiplex probands have more prevalence of sexual/religious and hoarding symptom…”
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Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes by Olfson, Emily, Farhat, Luis C., Liu, Wenzhong, Vitulano, Lawrence A., Zai, Gwyneth, Lima, Monicke O., Parent, Justin, Polanczyk, Guilherme V., Cappi, Carolina, Kennedy, James L., Fernandez, Thomas V.

“…Research demonstrates the important role of genetic factors in attention-deficit/hyperactivity disorder (ADHD). DNA sequencing of families provides a powerful…”
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De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette’s Disorder and Autism by Cappi, Carolina, Oliphant, Melody E., Péter, Zsanett, Zai, Gwyneth, Conceição do Rosário, Maria, Sullivan, Catherine A.W., Gupta, Abha R., Hoffman, Ellen J., Virdee, Manmeet, Olfson, Emily, Abdallah, Sarah B., Willsey, A. Jeremy, Shavitt, Roseli G., Miguel, Euripedes C., Kennedy, James L., Richter, Margaret A., Fernandez, Thomas V.

“…Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder with a genetic risk component, yet identification of high-confidence risk genes…”
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Base-editing corrects metabolic abnormalities in a humanized mouse model for glycogen storage disease type-Ia by Arnaoutova, Irina, Aratyn-Schaus, Yvonne, Zhang, Lisa, Packer, Michael S., Chen, Hung-Dar, Lee, Cheol, Gautam, Sudeep, Gregoire, Francine M., Leboeuf, Dominique, Boule, Steven, Fernandez, Thomas P., Huang, Victoria, Cheng, Lo-I, Lung, Genesis, Bannister, Brianna, Decker, Jeremy, Leete, Thomas, Shuang, Lan S., Bock, Caroline, Kothiyal, Prachi, Grayson, Phil, Mok, Ka W., Quinn, Jeffrey J., Young, Lauren, Barrera, Luis, Ciaramella, Giuseppe, Mansfield, Brian C., Chou, Janice Y.

“…Glycogen storage disease type-Ia patients, deficient in the G6PC1 gene encoding glucose-6-phosphatase-α, lack blood glucose control, resulting in…”
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