Search Results - "Fernandez, Patricia L."

Hemolysis-induced lethality involves inflammasome activation by heme by Dutra, Fabianno F, Alves, Letícia S, Rodrigues, Danielle, Fernandez, Patricia L, de Oliveira, Rosane B, Golenbock, Douglas T, Zamboni, Dario S, Bozza, Marcelo T

“…The increase of extracellular heme is a hallmark of hemolysis or extensive cell damage. Heme has prooxidant, cytotoxic, and inflammatory effects, playing a…”
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Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production by Fortes, Guilherme B., Alves, Leticia S., de Oliveira, Rosane, Dutra, Fabianno F., Rodrigues, Danielle, Fernandez, Patricia L., Souto-Padron, Thais, De Rosa, María José, Kelliher, Michelle, Golenbock, Douglas, Chan, Francis K.M., Bozza, Marcelo T.

“…Diseases that cause hemolysis or myonecrosis lead to the leakage of large amounts of heme proteins. Free heme has proinflammatory and cytotoxic effects. Heme…”
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Characterization of Heme as Activator of Toll-like Receptor 4 by Figueiredo, Rodrigo T., Fernandez, Patricia L., Mourao-Sa, Diego S., Porto, Bárbara N., Dutra, Fabianno F., Alves, Letícia S., Oliveira, Marcus F., Oliveira, Pedro L., Graça-Souza, Aurélio V., Bozza, Marcelo T.

“…Heme is an ancient and ubiquitous molecule present in organisms of all kingdoms, composed of an atom of iron linked to four ligand groups of porphyrin. A high…”
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Marine Diterpenoids as Potential Anti-Inflammatory Agents by Fernandez, Patricia L., Jones, Gillian E., Torres-Mendoza, Daniel, González, Yisett

“…The inflammatory response is a highly regulated process, and its dysregulation can lead to the establishment of chronic inflammation and, in some cases, to…”
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Anti-amyloid aggregation activity of novel carotenoids: implications for Alzheimer's drug discovery by Lakey-Beitia, Johant, Doens, Deborah, Jagadeesh Kumar, D, Murillo, Enrique, Fernandez, Patricia L, Rao, K S, Durant-Archibold, Armando A

“…Alzheimer's disease (AD) is the leading cause of dementia, affecting approximately 33.5 million people worldwide. Aging is the main risk factor associated with…”
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Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea by Torres-Mendoza, Daniel, González, Yisett, Gómez-Reyes, José Félix, Guzmán, Héctor M, López-Perez, José Luis, Gerwick, William H, Fernandez, Patricia L, Gutiérrez, Marcelino

“…Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH₂Cl₂-MeOH extract of the…”
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Microglia receptors and their implications in the response to amyloid β for Alzheimer's disease pathogenesis by Doens, Deborah, Fernández, Patricia L

“…Alzheimer's disease (AD) is a major public health problem with substantial economic and social impacts around the world. The hallmarks of AD pathogenesis…”
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Development of in-house, indirect ELISAs for the detection of SARS-CoV-2 spike protein-associated serology in COVID-19 patients in Panama by de la Guardia, Carolina, Rangel, Giselle, Villarreal, Alcibiades, Goodridge, Amador, Fernández, Patricia L, Lleonart, Ricardo

“…COVID-19 is the name of the acute respiratory disease caused by the new coronavirus SARS-CoV-2, a close relative of those that caused the severe outbreaks of…”
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Lethality associated with snake venom exposure can be predicted by temperature drop in Swiss mice by De Jesus, Rosa, Britton, Gabrielle B., Herrera, Lizzi, Madrid, Alanna, Lleonart, Ricardo, Fernández, Patricia L.

“…Establishing humane endpoints to minimize animal suffering in studies on snake venom toxicity and antivenom potency tests is crucial. Our findings reveal that…”
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Mitochondrial Reactive Oxygen Species Participate in Signaling Triggered by Heme in Macrophages and upon Hemolysis by Prestes, Elisa B, Alves, Letícia S, Rodrigues, Danielle A S, Dutra, Fabianno F, Fernandez, Patricia L, Paiva, Claudia N, Kagan, Jonathan C, Bozza, Marcelo T

“…Hemolysis causes an increase of intravascular heme, oxidative damage, and inflammation in which macrophages play a critical role. In these cells, heme can act…”
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Do B-1 cells play a role in response to Mycobacterium tuberculosis Beijing lineages? by Acosta, Fermín, Fernández, Patricia L., Goodridge, Amador

“…We highlight the need to include an analysis of the B-1 B cell subset to complement the characterization of the cell-mediated immune response to the…”
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Gene expression patterns associated with Leishmania panamensis infection in macrophages from BALB/c and C57BL/6 mice by Restrepo, Carlos M, Llanes, Alejandro, Herrera, Lizzi, Ellis, Esteban, Lleonart, Ricardo, Fernández, Patricia L

“…Leishmania parasites can trigger different host immune responses that result in varying levels of disease severity. The C57BL/6 and BALB/c mouse strains are…”
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Tetrahydrocurcumin Derivatives Enhanced the Anti-Inflammatory Activity of Curcumin: Synthesis, Biological Evaluation, and Structure-Activity Relationship Analysis by González, Yisett, Mojica-Flores, Randy, Moreno-Labrador, Dilan, Pecchio, Marisín, Rao, K S Jagannatha, Ahumedo-Monterrosa, Maicol, Fernández, Patricia L, Larionov, Oleg V, Lakey-Beitia, Johant

“…Tetrahydrocurcumin, the most abundant curcumin transformation product in biological systems, can potentially be a new alternative therapeutic agent with…”
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Polyphenols with Anti-Inflammatory Properties: Synthesis and Biological Activity of Novel Curcumin Derivatives by González, Yisett, Mojica-Flores, Randy, Moreno-Labrador, Dilan, Cubilla-Rios, Luis, Rao, K S Jagannatha, Fernández, Patricia L, Larionov, Oleg V, Lakey-Beitia, Johant

“…Herein, we describe the synthesis and evaluation of anti-inflammatory activities of new curcumin derivatives. The thirteen curcumin derivatives were…”
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Both B‐1a and B‐1b cells exposed to Mycobacterium tuberculosis lipids differentiate into IgM antibody‐secreting cells by Ordoñez, Ciara, Savage, Hannah P., Tarajia, Musharaf, Rivera, René, Weeks‐Galindo, Cheyenne, Sambrano, Dilcia, Riley, Lee, Fernandez, Patricia L., Baumgarth, Nicole, Goodridge, Amador

“…Summary Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. The cellular immune response to mycobacteria has been characterized…”
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Body Temperature Drop as a Humane Endpoint in Snake Venom-Lethality Neutralization Tests by De Jesus, Rosa, Tratner, Adam E, Madrid, Alanna, Rivera-Mondragón, Andrés, Navas, Goy E, Lleonart, Ricardo, Britton, Gabrielle B, Fernández, Patricia L

“…Snake venom neutralization potency tests are required for quality control assessment by manufacturers and regulatory authorities. These assays require the use…”
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Identification of Inhibitors of CD36-Amyloid Beta Binding as Potential Agents for Alzheimer’s Disease by Doens, Deborah, Valiente, Pedro A, Mfuh, Adelphe M, X. T. Vo, Anh, Tristan, Adilia, Carreño, Lizmar, Quijada, Mario, Nguyen, Vu T, Perry, George, Larionov, Oleg V, Lleonart, Ricardo, Fernández, Patricia L

“…Neuroinflammation is one of the hallmarks of Alzheimer’s disease pathology. Amyloid β has a central role in microglia activation and the subsequent secretion…”
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A Computational Approach to Explore the Interaction of Semisynthetic Nitrogenous Heterocyclic Compounds with the SARS-CoV-2 Main Protease by Llanes, Alejandro, Cruz, Héctor, Nguyen, Viet D, Larionov, Oleg V, Fernández, Patricia L

“…In the context of the ongoing coronavirus disease 2019 (COVID-19) pandemic, numerous attempts have been made to discover new potential antiviral molecules…”
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Topsoil Properties as Affected by Tillage Systems in the Rolling Pampa Region of Argentina by Alvarez, Carina R, Taboada, Miguel A, Gutierrez Boem, Flavio H, Bono, Alfredo, Fernandez, Patricia L, Prystupa, Pablo

“…Improved topsoil structural quality is expected under no-till farming, but soil physical constraints can develop under continuous no-till. Our objectives were:…”
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Correction: De Jesus et al. Body Temperature Drop as a Humane Endpoint in Snake Venom-Lethality Neutralization Tests. Toxins 2023, 15 , 525 by De Jesus, Rosa, Tratner, Adam E, Madrid, Alanna, Rivera-Mondragón, Andrés, Navas, Goy E, Lleonart, Ricardo, Britton, Gabrielle B, Fernández, Patricia L

“…In the original publication [...]…”
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