Search Results - "Fernandez, Minerva"

Next-generation sequencing identifies rare variants associated with Noonan syndrome by Chen, Peng-Chieh, Yin, Jiani, Yu, Hui-Wen, Yuan, Tao, Fernande, Minerva, Yung, Christina K., Trinh, Quang M., Peltekova, Vanya D., Reid, Jeffrey G., Tworog-Dube, Erica, Morgan, Margaret B., Muzny, Donna M., Stein, Lincoln, McPherson, John D., Roberts, Amy E., Gibbs, Richard A., Neel, Benjamin G., Kucherlapati, Raju

“…Noonan syndrome (NS) is a relatively common genetic disorder, characterized by typical facies, short stature, developmental delay, and cardiac abnormalities…”
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SHP2 Tyrosine Phosphatase Converts Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver by Takahashi, Atsushi, Tsutsumi, Ryouhei, Kikuchi, Ippei, Obuse, Chikashi, Saito, Yasuhiro, Seidi, Azadeh, Karisch, Robert, Fernandez, Minerva, Cho, Taewoo, Ohnishi, Naomi, Rozenblatt-Rosen, Orit, Meyerson, Matthew, Neel, Benjamin G., Hatakeyama, Masanori

“…Deregulation of SHP2 is associated with malignant diseases as well as developmental disorders. Although SHP2 is required for full activation of RAS signaling,…”
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Global Proteomic Assessment of the Classical Protein-Tyrosine Phosphatome and “Redoxome” by Karisch, Robert, Fernandez, Minerva, Taylor, Paul, Virtanen, Carl, St-Germain, Jonathan R., Jin, Lily L., Harris, Isaac S., Mori, Jun, Mak, Tak W., Senis, Yotis A., Östman, Arne, Moran, Michael F., Neel, Benjamin G.

“…Protein-tyrosine phosphatases (PTPs), along with protein-tyrosine kinases, play key roles in cellular signaling. All Class I PTPs contain an essential active…”
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Tyrosine Phosphorylation Mapping of the Epidermal Growth Factor Receptor Signaling Pathway by Steen, Hanno, Kuster, Bernhard, Fernandez, Minerva, Pandey, Akhilesh, Mann, Matthias

“…Phosphorylation is one of the most common forms of protein modification. The most frequent targets for protein phosphorylation in eukaryotes are serine and…”
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Detection of Tyrosine Phosphorylated Peptides by Precursor Ion Scanning Quadrupole TOF Mass Spectrometry in Positive Ion Mode by Steen, Hanno, Küster, Bernhard, Fernandez, Minerva, Pandey, Akhilesh, Mann, Matthias

“…Phosphorylation is a common form of protein modification. To understand its biological role, the site of phosphorylation has to be determined. Generally, only…”
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A Proteomic Approach for Identification of Secreted Proteins during the Differentiation of 3T3-L1 Preadipocytes to Adipocytes by Kratchmarova, Irina, Kalume, Dario E, Blagoev, Blagoy, Scherer, Philipp E, Podtelejnikov, Alexandre V, Molina, Henrik, Bickel, Perry E, Andersen, Jens S, Fernandez, Minerva M, Bunkenborg, Jacob, Roepstorff, Peter, Kristiansen, Karsten, Lodish, Harvey F, Mann, Matthias, Pandey, Akhilesh

“…We have undertaken a systematic proteomic approach to purify and identify secreted factors that are differentially expressed in preadipocytes versus…”
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Inhibition of adipocyte differentiation by resistin-like molecule alpha. Biochemical characterization of its oligomeric nature by Blagoev, Blagoy, Kratchmarova, Irina, Nielsen, Mogens M, Fernandez, Minerva M, Voldby, Jesper, Andersen, Jens S, Kristiansen, Karsten, Pandey, Akhilesh, Mann, Matthias

“…A novel family of cysteine-rich secreted proteins with unique tissue distribution has recently been identified. One of the members, resistin (for "resistance…”
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Phosphotyrosine Mapping in Bcr/Abl Oncoprotein Using Phosphotyrosine-specific Immonium Ion Scanning by Steen, Hanno, Fernandez, Minerva, Ghaffari, Saghi, Pandey, Akhilesh, Mann, Matthias

“…Bcr/Abl is a fusion oncoprotein that is of paramount importance in chronic myelogenous leukemia and acute lymphocytic leukemia. The tyrosine-phosphorylated…”
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Growth parameters, phytochemicals, and antitumor activity of wild and cultivated ice plants (Mesembryanthemum crystallinum L.) by Rincón‐Cervera, Miguel Ángel, Pagan Loeiro da Cunha‐Chiamolera, Tatiana, Chileh‐Chelh, Tarik, Carmona‐Fernández, Minerva, Urrestarazu, Miguel, Guil‐Guerrero, José Luis

“…The ice plant (Mesembryanthemum crystallinum L.) is a halophyte that could become an alternative crop because of its interest as a functional food and its…”
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A Novel Src Homology 2 Domain-containing Molecule, Src-like Adapter Protein-2 (SLAP-2), Which Negatively Regulates T Cell Receptor Signaling by Pandey, Akhilesh, Ibarrola, Nieves, Kratchmarova, Irina, Fernandez, Minerva M., Constantinescu, Stefan N., Ohara, Osamu, Sawasdikosol, Sansana, Lodish, Harvey F., Mann, Matthias

“…We have cloned a novel adapter protein containing Src homology 2 and Src homology 3 domains similar to the Src family of tyrosine kinases. This molecule lacks…”
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Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases by PANDEY, Akhilesh, BLAGOEV, Blagoy, MANN, Matthias, KRATCHMAROVA, Irina, FERNANDEZ, Minerva, NIELSEN, Mogens, KRISTIANSEN, Troels Zakarias, OHARA, Osamu, PODTELEJNIKOV, Alexandre V, ROCHE, Serge, LODISH, Harvey F

“…We have used a proteomic approach using mass spectrometry to identify signaling molecules involved in receptor tyrosine kinase signaling pathways. Using…”
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Bioactive compounds and bioactivity of the heads of wild artichokes by Chileh-Chelh, Tarik, Carmona-Fernández, Minerva, Ezzaitouni, Mohamed, Rincón-Cervera, Miguel Á., López-Ruiz, Rosalía, Gómez-Mercado, Francisco, Guil-Guerrero, José L.

“…Wild artichokes (Cyanara algarbiensis, C. baetica, C. cardunculus, and C. humilis) heads are globally consumed, although some taxa remain understudied,…”
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Identification of a Novel Immunoreceptor Tyrosine-based Activation Motif-containing Molecule, STAM2, by Mass Spectrometry and Its Involvement in Growth Factor and Cytokine Receptor Signaling Pathways by Pandey, A, Fernandez, M M, Steen, H, Blagoev, B, Nielsen, M M, Roche, S, Mann, M, Lodish, H F

“…In an effort to clone novel tyrosine-phosphorylated substrates of the epidermal growth factor receptor, we have initiated an approach coupling affinity…”
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Sexual Health Implications of Return Migration for Women and Their Partners in Rural Mexico: A Critical Ethnography by Fernandez-Sanchez, Higinio, Rocha-Fernandez, Minerva, Salma, Jordana, Santa Maria, Diane M, Benavides-Torres, Raquel A, Salami, Bukola

“…The return of a migrant partner can negatively impact the sexual health of women who stayed in their communities. Understanding their sexual health needs is…”
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Inflammatory Signatures Define a New High-Risk T-Lineage ALL Subtype by Gower, Mark, Li, Ximing, Aguilar-Navarro, Alicia, Lin, Brian, Fernandez, Minerva, Edun, Gibran, Nader, Mursal, Arruda, Andrea, Tierens, Anne Maria, Wagenblast, Elvin, Yang, Lin, Lee, Ho Seok, Loghavi, Sanam, Dick, John E., Minden, Mark D., Hitzler, Johann K., Jones, Courtney L, Schwartz, Gregory, Dolgalev, Igor, Jahangiri, Soheil, Tikhonova, Anastasia N.

“…T-lineage acute lymphoblastic leukemia (ALL) is an aggressive cancer comprising of diverse subtypes that are challenging to stratify using conventional…”
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Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies by Raman, Swetha, Beilschmidt, Melissa, To, Minh, Lin, Kevin, Lui, Francine, Jmeian, Yazen, Ng, Mark, Fernandez, Minerva, Fu, Ying, Mascall, Keith, Duque, Alejandro, Wang, Xiaowei, Pan, Guohua, Angers, Stephane, Moffat, Jason, Sidhu, Sachdev S., Magram, Jeanne, Sinclair, Angus M., Fransson, Johan, Julien, Jean-Philippe

“…Aberrant activation of Wnt/β-catenin signaling occurs frequently in cancer. However, therapeutic targeting of this pathway is complicated by the role of Wnt in…”
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Abstract NG14: Dissecting immune microenvironment of T-cell acute lymphoblastic leukemia by Gower, Mark, Fernandez, Minerva, Aruda, Andrea, Minden, Mark, Hitzler, Johann, Tikhonova, Anastasia

“…Abstract T-cell acute lymphoblastic leukemia (T-ALL) represents a particularly aggressive subtype of leukemia with no targeted therapies or immune…”
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Characterization of a recombinant monoclonal antibody by mass spectrometry combined with liquid chromatography by Fernández, Lobvi E.Matamoros, Kalume, Dário E., Calvo, Loany, Fernández Mallo, Minerva, Vallin, Antonio, Roepstorff, Peter

“…In this report, we present the characterization of a humanized monoclonal antibody specific for the human epidermal growth factor receptor (hEGFR). Direct…”
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Structure-guided engineering fine-tunes pharmacokinetics, tolerability and anti-tumor profile of anti-frizzled antibody by Raman, Swetha, Beilschmidt, Melissa, To, Minh, Lin, Kevin, Lui, Francine, Jmeian, Yazen, Ng, Mark, Fernandez, Minerva, Haybe, Zainab, Fu, Ying, Mascall, Keith, Pan, James, Angers, Stephane, Moffat, Jason, Sidhu, Sachdev S., Magram, Jeanne, Sinclair, Angus, Fransson, Johan, Julien, Jean-Philippe

“…Abstract only…”
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Producción diversificada de alimentos en patio y parcela para el autoconsumo familiar by Terry Espinosa, Caridad, Hernández Castellanos, Maritza, Almoguea Fernández, Minerva, Hernández Calzadilla, Reina Evelyn

“…Food security is when all people at all times have physical, social and economic access to sufficient, safe and nutritious food that meets their daily energy…”
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