Search Results - "Fernandez, Alejandro Anton"

Hippocampal rejuvenation by a single intracerebral injection of one-carbon metabolites in C57BL6 old wild-type mice by Antón-Fernández, Alejandro, Cauchola, Rocío Peinado, Hernández, Félix, Ávila, Jesús

“…The Izpisua-Belmonte group identified a cocktail of metabolites that promote partial reprogramming in cultured muscle cells. We tested the effect of brain…”
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Morphometric alterations of Golgi apparatus in Alzheimer's disease are related to tau hyperphosphorylation by Antón-Fernández, Alejandro, Aparicio-Torres, Guillermo, Tapia, Silvia, DeFelipe, Javier, Muñoz, Alberto

“…Abstract The Golgi apparatus (GA) is a highly dynamic organelle, which is mainly involved in the post-translational processing and targeting of cellular…”
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In vivo cyclic overexpression of Yamanaka factors restricted to neurons reverses age-associated phenotypes and enhances memory performance by Antón-Fernández, Alejandro, Roldán-Lázaro, Marta, Vallés-Saiz, Laura, Ávila, Jesús, Hernández, Félix

“…In recent years, there has been success in partially reprogramming peripheral organ cells using cyclic Yamanaka transcription factor (YF) expression, resulting…”
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Changes in the Golgi Apparatus of Neocortical and Hippocampal Neurons in the Hibernating Hamster by Antón-Fernández, Alejandro, León-Espinosa, Gonzalo, DeFelipe, Javier, Muñoz, Alberto

“…Hibernating animals have been used as models to study several aspects of the plastic changes that occur in the metabolism and physiology of neurons. These…”
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Neuronal nuclear tau and neurodegeneration by Antón-Fernández, Alejandro, Vallés-Saiz, Laura, Avila, Jesús, Hernández, Félix

“…•Tau is present in the nucleus.•Tau binds to DNA present in the nucleolus and pericentromeric heterochromatin.•Tau bind to RNA.•Pathogenic tau alters nuclear…”
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Gut Microbiota, an Additional Hallmark of Human Aging and Neurodegeneration by Molinero, Natalia, Antón-Fernández, Alejandro, Hernández, Félix, Ávila, Jesús, Bartolomé, Begoña, Moreno-Arribas, M. Victoria

“…•Gut-brain axis is involve in aged-related neurological disorders like Alzheimer.•Oral and gut dysbiosis has been associated to biomarkers of cognitive…”
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Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease by Pickett, Eleanor K., Herrmann, Abigail G., McQueen, Jamie, Abt, Kimberly, Dando, Owen, Tulloch, Jane, Jain, Pooja, Dunnett, Sophie, Sohrabi, Sadaf, Fjeldstad, Maria P., Calkin, Will, Murison, Leo, Jackson, Rosemary J., Tzioras, Makis, Stevenson, Anna, d’Orange, Marie, Hooley, Monique, Davies, Caitlin, Colom-Cadena, Marti, Anton-Fernandez, Alejandro, King, Declan, Oren, Iris, Rose, Jamie, McKenzie, Chris-Anne, Allison, Elizabeth, Smith, Colin, Hardt, Oliver, Henstridge, Christopher M., Hardingham, Giles E., Spires-Jones, Tara L.

“…A key knowledge gap blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) peptide…”
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[F-18]-AV-1451 binding correlates with postmortem neurofibrillary tangle Braak staging by Marquié, Marta, Siao Tick Chong, Michael, Antón-Fernández, Alejandro, Verwer, Eline E., Sáez-Calveras, Nil, Meltzer, Avery C., Ramanan, Prianca, Amaral, Ana C., Gonzalez, Jose, Normandin, Marc D., Frosch, Matthew P., Gómez-Isla, Teresa

“…[F-18]-AV-1451, a PET tracer specifically developed to detect brain neurofibrillary tau pathology, has the potential to facilitate accurate diagnosis of…”
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Modifications of the axon initial segment during the hibernation of the Syrian hamster by León-Espinosa, Gonzalo, Antón-Fernández, Alejandro, Tapia-González, Silvia, DeFelipe, Javier, Muñoz, Alberto

“…Mammalian hibernation is a natural process in which the brain undergoes profound adaptive changes that appear to protect the brain from extreme hypoxia and…”
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Selective presence of a giant saccular organelle in the axon initial segment of a subpopulation of layer V pyramidal neurons by Antón-Fernández, Alejandro, Rubio-Garrido, Pablo, DeFelipe, Javier, Muñoz, Alberto

“…Recently it has been shown that a giant saccular organelle (GSO) of unknown function is present in the axon initial segment (AIS) of an uncharacterized…”
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Phospho-Tau Accumulation and Structural Alterations of the Golgi Apparatus of Cortical Pyramidal Neurons in the P301S Tauopathy Mouse Model by Antón-Fernández, Alejandro, Merchán-Rubira, Jesús, Avila, Jesús, Hernández, Félix, DeFelipe, Javier, Muñoz, Alberto

“…The Golgi apparatus (GA) is a highly dynamic organelle involved in the processing and sorting of cellular proteins. In Alzheimer's disease (AD), it has been…”
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Pathological correlations of [F‐18]‐AV‐1451 imaging in non‐alzheimer tauopathies by Marquié, Marta, Normandin, Marc D., Meltzer, Avery C., Siao Tick Chong, Michael, Andrea, Nicolas V., Antón‐Fernández, Alejandro, Klunk, William E., Mathis, Chester A., Ikonomovic, Milos D., Debnath, Manik, Bien, Elizabeth A., Vanderburg, Charles R., Costantino, Isabel, Makaretz, Sara, DeVos, Sarah L., Oakley, Derek H., Gomperts, Stephen N., Growdon, John H., Domoto‐Reilly, Kimiko, Lucente, Diane, Dickerson, Bradford C., Frosch, Matthew P., Hyman, Bradley T., Johnson, Keith A., Gómez‐Isla, Teresa

“…Objective Recent studies have shown that positron emission tomography (PET) tracer AV‐1451 exhibits high binding affinity for paired helical filament (PHF)‐tau…”
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RELATIONSHIP BETWEEN PHOSPHO-TAU ACCUMULATION AND STRUCTURAL ALTERATIONS OF NEURONAL GOLGI APPARATUS IN ALZHEIMER’S DISEASE PATIENTS AND P301S TAUOPATHY MOUSE MODEL by Fernandez, Alejandro Anton, Torres, Guillermo Aparicio, Rubira, Jesús Merchan, Gonzalez, Silvia Tapia, Defelipe, Javier, Avila, Jesus, Hernandez, Félix, Muñoz, Alberto

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Pyramidal cell axon initial segment in Alzheimer´s disease by Antón-Fernández, Alejandro, León-Espinosa, Gonzalo, DeFelipe, Javier, Muñoz, Alberto

“…The axon initial segment (AIS) is a region of the neuron that is critical for action potential generation as well as for the regulation of neural activity…”
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Pathologic correlations of [F-18]-AV-1451 imaging in non-Alzheimer tauopathies by Marquié, Marta, Normandin, Marc D., Meltzer, Avery C., Chong, Michael Siao Tick, Andrea, Nicolas V., Antón-Fernández, Alejandro, Klunk, William E., Mathis, Chester A., Ikonomovic, Milos D., Debnath, Manik, Bien, Elizabeth A., Vanderburg, Charles R., Costantino, Isabel, Makaretz, Sara, DeVos, Sarah L., Oakley, Derek H., Gomperts, Stephen N., Growdon, John H., Domoto-Reilly, Kimiko, Lucente, Diane, Dickerson, Bradford C., Frosch, Matthew P., Hyman, Bradley T., Johnson, Keith A., Gómez-Isla, Teresa

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