Genetic Variants of MicroRNA and DROSHA Genes in Association With the Risk of Tuberculosis in the Amazon Population

Tuberculosis (TB) is a chronic infection caused by (Mtb) with high incidence and mortality. Studies reported that host genetic variants might be associated with the risk of tuberculosis. The aim of this study was to perform an association study between 26 single nucleotide polymorphisms (SNPs) and t...

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Published in:	Frontiers in genetics Vol. 13; p. 850058
Main Authors:	Leal, Diana Feio da Veiga Borges, Santana da Silva, Mayara Natália, Pastana, Lucas Favacho, Fernandes, Marianne Rodrigues, de Athayde, Aidalucy do Socorro Costa, Fernandes Porchera, Débora Christina Ricardo, da Silva, Cleonardo Augusto, Modesto, Antônio André Conde, De Assumpcão, Paulo Pimentel, Dos Santos, Sidney Emanuel Batista, Dos Santos, Ney Pereira Carneiro
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 02-03-2022
Subjects:	drosha genetic variants Genetics microRNA risk factor tuberculosis genetic variants microRNA drosha risk factor tuberculosis
Online Access:	Get full text
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Summary:	Tuberculosis (TB) is a chronic infection caused by (Mtb) with high incidence and mortality. Studies reported that host genetic variants might be associated with the risk of tuberculosis. The aim of this study was to perform an association study between 26 single nucleotide polymorphisms (SNPs) and tuberculosis and evaluate whether these SNPs may confer risk factors to tuberculosis in the Amazon population. There were 52 males and 126 females, with total of 178 healthy controls. Genotyping was performed using TaqMan Open Array Genotyping. Ancestry-informative markers were used to estimate the ancestral proportions of the individuals in the case and control groups. The results indicated that the SNPs rs10035440 (DROSHA), rs7372209 (miR26-a1), rs1834306 (miR100), rs4919510 (miR608), and rs10739971 (pri-let-7a-1) were significantly associated with high risk and rs3746444 (miR499) and rs6505162 (miR423), with low risk of developing tuberculosis in the Amazon population. Our study concluded that seven miRNA polymorphisms were associated with tuberculosis. Our study contributes to a better understanding of TB pathogenesis and may promote the development of new diagnostic tools against infection.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Aftab Ali Shah, University of Malakand, Pakistan Reviewed by: Balint Nagy, University of Debrecen, Hungary Afsoon Afshari, Shiraz University of Medical Sciences, Iran This article was submitted to RNA, a section of the journal Frontiers in Genetics
ISSN:	1664-8021 1664-8021
DOI:	10.3389/fgene.2022.850058