Search Results - "Fernandes, Ricardo A"

Can we predict T cell specificity with digital biology and machine learning? by Hudson, Dan, Fernandes, Ricardo A., Basham, Mark, Ogg, Graham, Koohy, Hashem

“…Recent advances in machine learning and experimental biology have offered breakthrough solutions to problems such as protein structure prediction that were…”
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RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development by Wang, Jie, Miao, Yi, Wicklein, Rebecca, Sun, Zijun, Wang, Jinzhao, Jude, Kevin M., Fernandes, Ricardo A., Merrill, Sean A., Wernig, Marius, Garcia, K. Christopher, Südhof, Thomas C.

“…RTN4-binding proteins were widely studied as “NoGo” receptors, but their physiological interactors and roles remain elusive. Similarly, BAI adhesion-GPCRs were…”
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Autoimmunity-associated T cell receptors recognize HLA-B27-bound peptides by Yang, Xinbo, Garner, Lee I., Zvyagin, Ivan V., Paley, Michael A., Komech, Ekaterina A., Jude, Kevin M., Zhao, Xiang, Fernandes, Ricardo A., Hassman, Lynn M., Paley, Grace L., Savvides, Christina S., Brackenridge, Simon, Quastel, Max N., Chudakov, Dmitriy M., Bowness, Paul, Yokoyama, Wayne M., McMichael, Andrew J., Gillespie, Geraldine M., Garcia, K. Christopher

“…Human leucocyte antigen B*27 (HLA-B*27) is strongly associated with inflammatory diseases of the spine and pelvis (for example, ankylosing spondylitis (AS))…”
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Feature Extraction and Power Quality Disturbances Classification Using Smart Meters Signals by Borges, Fabbio A. S., Fernandes, Ricardo A. S., Silva, Ivan N., Silva, Cintia B. S.

“…This paper presents a methodology aimed at extracting features to obtain information that will highlight disturbances related to the field of power quality…”
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Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia by Liang, Zhu, Damianou, Andreas, Vendrell, Iolanda, Jenkins, Edward, Lassen, Frederik H., Washer, Sam J., Grigoriou, Athina, Liu, Guihai, Yi, Gangshun, Lou, Hantao, Cao, Fangyuan, Zheng, Xiaonan, Fernandes, Ricardo A., Dong, Tao, Tate, Edward W., Di Daniel, Elena, Kessler, Benedikt M.

“…Activation of the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome complex is an essential innate immune signaling mechanism. To reveal…”
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A robust deep learning workflow to predict CD8 + T-cell epitopes by Lee, Chloe H, Huh, Jaesung, Buckley, Paul R, Jang, Myeongjun, Pinho, Mariana Pereira, Fernandes, Ricardo A, Antanaviciute, Agne, Simmons, Alison, Koohy, Hashem

“…T-cells play a crucial role in the adaptive immune system by triggering responses against cancer cells and pathogens, while maintaining tolerance against…”
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Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation by Fritzsche, Marco, Fernandes, Ricardo A, Chang, Veronica T, Colin-York, Huw, Clausen, Mathias P, Felce, James H, Galiani, Silvia, Erlenkämper, Christoph, Santos, Ana M, Heddleston, John M, Pedroza-Pacheco, Isabela, Waithe, Dominic, de la Serna, Jorge Bernardino, Lagerholm, B Christoffer, Liu, Tsung-Li, Chew, Teng-Leong, Betzig, Eric, Davis, Simon J, Eggeling, Christian

“…T cell activation and especially trafficking of T cell receptor microclusters during immunological synapse formation are widely thought to rely on cytoskeletal…”
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Oncolytic viruses and antibodies: are they more successful when delivered separately or when engineered as a single agent? by Wan, Peter Kok-Ting, Fernandes, Ricardo A, Seymour, Leonard W

“…Oncolytic viruses (OVs) provide the promise of tumor-selective cytotoxicity coupled with amplification of the therapeutic agent (the virus) within the tumor…”
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Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo by Fernandes, Ricardo A, Li, Chaoran, Wang, Gang, Yang, Xinbo, Savvides, Christina S, Glassman, Caleb R, Dong, Shen, Luxenberg, Eric, Sibener, Leah V, Birnbaum, Michael E, Benoist, Christophe, Mathis, Diane, Garcia, K Christopher

“…T regulatory (Treg) cells play vital roles in modulating immunity and tissue homeostasis. Their actions depend on TCR recognition of peptide-MHC molecules; yet…”
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Deep Transfer Learning-Based Feature Extraction: An Approach to Improve Nonintrusive Load Monitoring by Cavalca, Diego L., Fernandes, Ricardo A. S.

“…The development of techniques that allow the efficient identification of residential loads (nonintrusive load monitoring) is a key factor for the practical…”
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DySCo: Quantitating Associations of Membrane Proteins Using Two-Color Single-Molecule Tracking by Dunne, Paul D., Fernandes, Ricardo A., McColl, James, Yoon, Ji Won, James, John R., Davis, Simon J., Klenerman, David

“…We present a general method called dynamic single-molecule colocalization for quantitating the associations of single cell surface molecules labeled with…”
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Diabetes and peripheral neuropathy are related to higher passive torque and stiffness of the knee and ankle joints by Ferreira, Jean P, Araujo, Vanessa L, Leal, Angela M. O, Serrao, Paula R. M. S, Perea, Julya P. M, Santune, Afonso H. A, Pott-Junior, Henrique, Fernandes, Ricardo A. S, Aranha, Gabriel D. A, Sacco, Isabel C. N, Salvini, Tania F

“…The aim of this study was to investigate the ankle and knee stiffness and passive torque in individuals with diabetes mellitus type 2 (DM2), with and without…”
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Deep Transfer Learning Strategy to Diagnose Eye-Related Conditions and Diseases: An Approach Based on Low-Quality Fundus Images by Aranha, Gabriel D. A., Fernandes, Ricardo A. S., Morales, Paulo H. A.

“…Data from the World Health Organization indicate that billion cases of visual impairment could be avoided, mainly with regular examinations. However, the…”
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Heat Stress and Hormetin-Induced Hormesis in Human Cells: Effects on Aging, Wound Healing, Angiogenesis, and Differentiation by Rattan, Suresh I. S., Fernandes, Ricardo A., Demirovic, Dino, Dymek, Barbara, Lima, Cristovao F.

“…Accumulation of molecular damage and increased molecular heterogeneity are hallmarks of cellular aging. Mild stress-induced hormesis can be an effective way…”
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Biopsychosocial Aspects in Individuals with Acute and Chronic Rotator Cuff Related Shoulder Pain: Classification Based on a Decision Tree Analysis by Haik, Melina N, Alburquerque-Sendín, Francisco, Fernandes, Ricardo A S, Kamonseki, Danilo H, Almeida, Lucas A, Liebano, Richard E, Camargo, Paula R

“…Biopsychosocial aspects seem to influence the clinical condition of rotator cuff related shoulder pain (RCRSP). However, traditional bivariate and linear…”
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Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM by Lanz, Tobias V., Brewer, R. Camille, Ho, Peggy P., Moon, Jae-Seung, Jude, Kevin M., Fernandez, Daniel, Fernandes, Ricardo A., Gomez, Alejandro M., Nadj, Gabriel-Stefan, Bartley, Christopher M., Schubert, Ryan D., Hawes, Isobel A., Vazquez, Sara E., Iyer, Manasi, Zuchero, J. Bradley, Teegen, Bianca, Dunn, Jeffrey E., Lock, Christopher B., Kipp, Lucas B., Cotham, Victoria C., Ueberheide, Beatrix M., Aftab, Blake T., Anderson, Mark S., DeRisi, Joseph L., Wilson, Michael R., Bashford-Rogers, Rachael J. M., Platten, Michael, Garcia, K. Christopher, Steinman, Lawrence, Robinson, William H.

“…Multiple sclerosis (MS) is a heterogenous autoimmune disease in which autoreactive lymphocytes attack the myelin sheath of the central nervous system. B…”
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Opposing T cell responses in experimental autoimmune encephalomyelitis by Saligrama, Naresha, Zhao, Fan, Sikora, Michael J., Serratelli, William S., Fernandes, Ricardo A., Louis, David M., Yao, Winnie, Ji, Xuhuai, Idoyaga, Juliana, Mahajan, Vinit B., Steinmetz, Lars M., Chien, Yueh-Hsiu, Hauser, Stephen L., Oksenberg, Jorge R., Garcia, K. Christopher, Davis, Mark M.

“…Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded CD4 +…”
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Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding by Sibener, Leah V., Fernandes, Ricardo A., Kolawole, Elizabeth M., Carbone, Catherine B., Liu, Fan, McAffee, Darren, Birnbaum, Michael E., Yang, Xinbo, Su, Laura F., Yu, Wong, Dong, Shen, Gee, Marvin H., Jude, Kevin M., Davis, Mark M., Groves, Jay T., Goddard, William A., Heath, James R., Evavold, Brian D., Vale, Ronald D., Garcia, K. Christopher

“…TCR-signaling strength generally correlates with peptide-MHC binding affinity; however, exceptions exist. We find high-affinity, yet non-stimulatory,…”
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Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC by Sušac, Lukas, Vuong, Mai T., Thomas, Christoph, von Bülow, Sören, O’Brien-Ball, Caitlin, Santos, Ana Mafalda, Fernandes, Ricardo A., Hummer, Gerhard, Tampé, Robert, Davis, Simon J.

“…The T cell receptor (TCR) expressed by T lymphocytes initiates protective immune responses to pathogens and tumors. To explore the structural basis of how TCR…”
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Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes by Gee, Marvin H., Han, Arnold, Lofgren, Shane M., Beausang, John F., Mendoza, Juan L., Birnbaum, Michael E., Bethune, Michael T., Fischer, Suzanne, Yang, Xinbo, Gomez-Eerland, Raquel, Bingham, David B., Sibener, Leah V., Fernandes, Ricardo A., Velasco, Andrew, Baltimore, David, Schumacher, Ton N., Khatri, Purvesh, Quake, Stephen R., Davis, Mark M., Garcia, K. Christopher

“…The immune system can mount T cell responses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes (TILs) are not well…”
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