Search Results - "Fernandes, Karl J L"

Untangling the influences of voluntary running, environmental complexity, social housing and stress on adult hippocampal neurogenesis by Grégoire, Catherine-Alexandra, Bonenfant, David, Le Nguyen, Adalie, Aumont, Anne, Fernandes, Karl J L

“…Environmental enrichment (EE) exerts powerful effects on brain physiology, and is widely used as an experimental and therapeutic tool. Typical EE paradigms are…”
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Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer’s disease mouse model by Hamilton, Laura K., Moquin-Beaudry, Gaël, Mangahas, Chenicka L., Pratesi, Federico, Aubin, Myriam, Aumont, Anne, Joppé, Sandra E., Légiot, Alexandre, Vachon, Annick, Plourde, Mélanie, Mounier, Catherine, Tétreault, Martine, Fernandes, Karl J. L.

“…The defining features of Alzheimer’s disease (AD) include alterations in protein aggregation, immunity, lipid metabolism, synapses, and learning and memory. Of…”
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Central inhibition of stearoyl-CoA desaturase has minimal effects on the peripheral metabolic symptoms of the 3xTg Alzheimer’s disease mouse model by Hamilton, Laura K., M’Bra, Paule E. H., Mailloux, Sophia, Galoppin, Manon, Aumont, Anne, Fernandes, Karl J. L.

“…Evidence from genetic and epidemiological studies point to lipid metabolism defects in both the brain and periphery being at the core of Alzheimer’s disease…”
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Author Correction: Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer’s disease mouse model by Hamilton, Laura K., Moquin-Beaudry, Gaël, Mangahas, Chenicka L., Pratesi, Federico, Aubin, Myriam, Aumont, Anne, Joppé, Sandra E., Légiot, Alexandre, Vachon, Annick, Plourde, Mélanie, Mounier, Catherine, Tétreault, Martine, Fernandes, Karl J. L.

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Central canal ependymal cells proliferate extensively in response to traumatic spinal cord injury but not demyelinating lesions by Lacroix, Steve, Hamilton, Laura K, Vaugeois, Alexandre, Beaudoin, Stéfanny, Breault-Dugas, Christian, Pineau, Isabelle, Lévesque, Sébastien A, Grégoire, Catherine-Alexandra, Fernandes, Karl J L

“…The adult mammalian spinal cord has limited regenerative capacity in settings such as spinal cord injury (SCI) and multiple sclerosis (MS). Recent studies have…”
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Endogenous neural stem cell responses to stroke and spinal cord injury by Grégoire, Catherine-Alexandra, Goldenstein, Brianna L., Floriddia, Elisa M., Barnabé-Heider, Fanie, Fernandes, Karl J. L.

“…Stroke and spinal cord injury (SCI) are among the most frequent causes of central nervous system (CNS) dysfunction, affecting millions of people worldwide each…”
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Isolation of multipotent adult stem cells from the dermis of mammalian skin by Miller, Freda D, Toma, Jean G, Akhavan, Mahnaz, Fernandes, Karl J. L, Barnabé-Heider, Fanie, Sadikot, Abbas, Kaplan, David R

“…We describe here the isolation of stem cells from juvenile and adult rodent skin. These cells derive from the dermis, and clones of individual cells can…”
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Mammalian target of rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain by Paliouras, Grigorios N, Hamilton, Laura K, Aumont, Anne, Joppé, Sandra E, Barnabé-Heider, Fanie, Fernandes, Karl J L

“…Adult forebrain neurogenesis is dynamically regulated. Multiple families of niche-derived cues have been implicated in this regulation, but the precise roles…”
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Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease by Hamilton, Laura K., Aumont, Anne, Julien, Carl, Vadnais, Alexandra, Calon, Frédéric, Fernandes, Karl J. L.

“…Alzheimer’s disease (AD) affects cognitive modalities that are known to be regulated by adult neurogenesis, such as hippocampal‐ and olfactory‐dependent…”
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Aging and neurogenesis in the adult forebrain: what we have learned and where we should go from here by Hamilton, Laura K., Joppé, Sandra E., M. Cochard, Loїc, Fernandes, Karl J. L.

“…In the brains of adult vertebrates, including humans, neurogenesis occurs in restricted niches where it maintains cellular turnover and cognitive plasticity…”
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Manipulation of EGFR-Induced Signaling for the Recruitment of Quiescent Neural Stem Cells in the Adult Mouse Forebrain by Cochard, Loïc M, Levros, Jr, Louis-Charles, Joppé, Sandra E, Pratesi, Federico, Aumont, Anne, Fernandes, Karl J L

“…The ventricular-subventricular zone (V-SVZ) is the principal neurogenic niche in the adult mammalian forebrain. Neural stem/progenitor cell (NSPC) activity…”
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A dermal niche for multipotent adult skin-derived precursor cells by Miller, Freda D, Fernandes, Karl J. L, McKenzie, Ian A, Mill, Pleasantine, Smith, Kristen M, Akhavan, Mahnaz, Barnabé-Heider, Fanie, Biernaskie, Jeff, Junek, Adrienne, Kobayashi, Nao R, Toma, Jean G, Kaplan, David R, Labosky, Patricia A, Rafuse, Victor, Hui, Chi-Chung

“…A fundamental question in stem cell research is whether cultured multipotent adult stem cells represent endogenous multipotent precursor cells. Here we address…”
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Multipotent skin-derived precursors: adult neural crest-related precursors with therapeutic potential by Fernandes, Karl J.L, Toma, Jean G, Miller, Freda D

“…and are an apparently novel precursor cell type that is distinct from other known precursors within the skin. In this review, we begin by placing these…”
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Analysis of the neurogenic potential of multipotent skin-derived precursors by Fernandes, Karl J.L., Kobayashi, Nao R., Gallagher, Conor J., Barnabé-Heider, Fanie, Aumont, Anne, Kaplan, David R., Miller, Freda D.

“…Multipotent precursors similar to stem cells of the embryonic neural crest (NC) have been identified in several postnatal tissues, and are potentially useful…”
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RNA-Sequencing Reveals Unique Transcriptional Signatures of Running and Running-Independent Environmental Enrichment in the Adult Mouse Dentate Gyrus by Grégoire, Catherine-Alexandra, Tobin, Stephanie, Goldenstein, Brianna L, Samarut, Éric, Leclerc, Andréanne, Aumont, Anne, Drapeau, Pierre, Fulton, Stephanie, Fernandes, Karl J L

“…Environmental enrichment (EE) is a powerful stimulus of brain plasticity and is among the most accessible treatment options for brain disease. In rodents, EE…”
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Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease by Hamilton, Laura K., Dufresne, Martin, Joppé, Sandra E., Petryszyn, Sarah, Aumont, Anne, Calon, Frédéric, Barnabé-Heider, Fanie, Furtos, Alexandra, Parent, Martin, Chaurand, Pierre, Fernandes, Karl J.L.

“…Lipid metabolism is fundamental for brain development and function, but its roles in normal and pathological neural stem cell (NSC) regulation remain largely…”
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Caspase-3 is activated following axotomy of neonatal facial motoneurons and caspase-3 gene deletion delays axotomy-induced cell death in rodents by Vanderluit, Jacqueline L., McPhail, Lowell T., Fernandes, Karl J. L., McBride, Christopher B., Huguenot, Claire, Roy, Sophie, Robertson, George S., Nicholson, Donald W., Tetzlaff, Wolfram

“…In this report, we examined the possible functions of the cell death protease, caspase‐3, in the axotomy‐induced apoptosis of facial motoneurons in newborn…”
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Neural stem cells and adult brain fatty acid metabolism: Lessons from the 3xTg model of Alzheimer's disease by Hamilton, Laura K., Fernandes, Karl J. L.

“…Neural stem cell (NSC) activity and adult neurogenesis are physiologically relevant regulators of adult brain structure, function and repair. Given these…”
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FoxJ1 regulates spinal cord development and is required for the maintenance of spinal cord stem cell potential by Li, Xiaofei, Floriddia, Elisa M., Toskas, Konstantinos, Chalfouh, Chaima, Honore, Axel, Aumont, Anne, Vallières, Nicolas, Lacroix, Steve, Fernandes, Karl J.L., Guérout, Nicolas, Barnabé-Heider, Fanie

“…Development of the spinal cord requires dynamic and tightly controlled expression of numerous transcription factors. Forkhead Box protein J1 (FoxJ1) is a…”
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Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over Time by Li, Xiaofei, Floriddia, Elisa M., Toskas, Konstantinos, Fernandes, Karl J.L., Guérout, Nicolas, Barnabé-Heider, Fanie

“…Stem cells have a high therapeutic potential for the treatment of spinal cord injury (SCI). We have shown previously that endogenous stem cell potential is…”
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