Search Results - "Fernandes, João Paulo S."

The Importance of Medicinal Chemistry Knowledge in the Clinical Pharmacist’s Education by Fernandes, João Paulo S.

“…Objective. To show why medicinal chemistry must be a key component of the education of pharmacy students, as well as in the pharmacist’s practice. Findings…”
Get full text

Metabolite profile of Nectandra oppositifolia Nees & Mart. and assessment of antitrypanosomal activity of bioactive compounds through efficiency analyses by Alves Conserva, Geanne A, Quirós-Guerrero, Luis M, Costa-Silva, Thais A, Marcourt, Laurence, Pinto, Erika G, Tempone, Andre G, Fernandes, João Paulo S, Wolfender, Jean-Luc, Queiroz, Emerson F, Lago, João Henrique G

“…EtOH extracts from the leaves and twigs of Nectandra oppositifolia Nees & Mart. shown activity against amastigote forms of Trypanosoma cruzi. These extracts…”
Get full text

Piperazine amides with desirable solubility, physicochemical and drug-like properties: Synthesis and evaluation of the anti-Trypanosoma cruzi activity by Varela, Marina T., Romanelli, Maiara, Amaral, Maiara, Tempone, Andre G., Fernandes, João Paulo S.

“…The absence of effective chronic treatment, expansion to non-endemic countries and the significant burden in public health have stimulated the search for novel…”
Get full text

Antihistamines H1 as Potential Anthelmintic Agents against the Zoonotic Parasite Angiostrongylus cantonensis by Roquini, Daniel B., Lemes, Bruna L., Kreutz, Amanda L. B., Spoladore, Sophia C., Amaro, Monique C., Lopes, Flavia B., Fernandes, João Paulo S., de Moraes, Josué

“…Infections caused by parasitic helminths pose significant health concerns for both humans and animals. The limited efficacy of existing drugs underscores the…”
Get full text

Synthetic Analogues of Gibbilimbol B Induce Bioenergetic Damage and Calcium Imbalance in Trypanosoma cruzi by Amaral, Maiara, Varela, Marina T, Kant, Ravi, Christodoulides, Myron, Fernandes, João Paulo S, Tempone, Andre G

“…Chagas disease is an endemic tropical disease caused by the protozoan , which affects around 7 million people worldwide, mostly in development countries. The…”
Get full text

Investigation of Structure–Activity Relationships for Benzoyl and Cinnamoyl Piperazine/Piperidine Amides as Tyrosinase Inhibitors by Varela, Marina T., de Castro Levatti, Erica V., Tempone, Andre G., Fernandes, João Paulo S.

“…Melanin is a substance that plays important roles in several organisms. Its function as an antioxidant and metal-complexing agent makes tyrosinase, the key…”
Get full text

Gibbilimbol analogues as antiparasitic agents—Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum by Varela, Marina T., Dias, Roberto Z., Martins, Ligia F., Ferreira, Daiane D., Tempone, Andre G., Ueno, Anderson K., Lago, João Henrique G., Fernandes, João Paulo S.

“…[Display omitted] The essential oils from leaves of Piper malacophyllum (Piperaceae) showed to be mainly composed by two alkenylphenol derivatives:…”
Get full text

Histamine research advancements in the second year of the COVID-19 pandemic: report of the European Histamine Research Society (EHRS) by Obara, Ilona, Fernandes, João Paulo S., Tiligada, Ekaterini

“…In the light of cancellation of the 50th Annual Meeting of the European Histamine Research Society (EHRS) due to continuing challenges and restrictions imposed…”
Get full text

Esterification of p -Coumaric Acid Improves the Control over Melanoma Cell Growth by Carmo-Martins, Joana I, Gonzatti, Michelangelo B, Varela, Marina T, Sousa, Maria Eduarda P, Costa, Lucas V S, Rodrigues, Elaine Guadelupe, Fernandes, João Paulo S, Keller, Alexandre C

“…Previous studies reported that p-coumaric acid modulates melanoma growth. Because the esterification of p-coumaric acid (p-CA) enhanced its activity as an…”
Get full text

Differential contribution of H3R antagonism by LINS01 compounds on memory, anxiety-like behaviour and spontaneous locomotor activity in healthy rats by Soliani, Andressa, Kubota, Silvia Megumi, Corrêa, Michelle Fidelis, Cerutti, Suzete Maria, Fernandes, João Paulo S.

“…[Display omitted] •LINS01 compounds are promising histamine H3 receptor antagonists.•LINS01004 did not impair memory in healthy rats.•LINS01 molecules did not…”
Get full text

Coumaric acid derivatives as tyrosinase inhibitors: Efficacy studies through in silico, in vitro and ex vivo approaches by Varela, Marina Themoteo, Ferrarini, Márcio, Mercaldi, Vitória Gallo, Sufi, Bianca da Silva, Padovani, Giovana, Nazato, Lucas Idacir Sbrugnera, Fernandes, João Paulo S.

“…[Display omitted] •The p-coumaric acid esters are inhibitors of tyrosinase.•The antimelanogenic activity is independent of radical scavenging effect.•The…”
Get full text

Toward anthelmintic drug candidates for toxocariasis: Challenges and recent developments by Mengarda, Ana C., Silva, Tais C., Silva, Aline S., Roquini, Daniel B., Fernandes, João Paulo S., de Moraes, Josué

“…Infections caused by parasitic helminths rank among the most prevalent infections of humans and animals. Toxocariasis, caused by nematodes of the genus…”
Get full text

Lethal action of Licarin A derivatives in Leishmania (L.) infantum: Imbalance of calcium and bioenergetic metabolism by de Castro Levatti, Erica V., Costa-Silva, Thais A., Morais, Thiago R., Fernandes, João Paulo S., Lago, João Henrique G., Tempone, Andre G.

“…Natural metabolites present an extraordinary chemo-diversity and have been used as the inspiration for new drugs. Considering the need for new treatments…”
Get full text

Histamine H3 receptor and cholinesterases as synergistic targets for cognitive decline: Strategies to the rational design of multitarget ligands by Lopes, Flávia B., Aranha, Cecília M. S. Q., Fernandes, João Paulo S.

“…The role of histamine and acetylcholine in cognitive functions suggests that compounds able to increase both histaminergic and cholinergic neurotransmissions…”
Get full text

The histamine H4 receptor antagonist 1-[(5-chloro-2,3-dihydro-1-benzofuran-2-yl)methyl]-4-methyl-piperazine(LINS01007) prevents the development of DSS-induced colitis in mice by Lippi, Beatriz K., Fernandes, Gustavo A.B., Azevedo, Gabriela A., Negreiros, Nathani G.S., Soares, Antonio W, Landgraf, Maristella A., Fernandes, João Paulo S., Landgraf, Richardt G.

“…•A new H4R antagonist prevents the development of DSS-induced colitis in mice.•Histological signs were significantly reduced in animals treated with…”
Get full text

Multitargeting approaches to cognitive impairment: Synthesis of aryl-alkylpiperazines and assessment at cholinesterases, histamine H3 and dopamine D3 receptors by Aranha, Cecília M.S.Q., Reiner-Link, David, Leitzbach, Luisa R., Lopes, Flavia B., Stark, Holger, Fernandes, João Paulo S.

“…[Display omitted] Multitargeting ligands on enzymes and receptors may generate a profile for a potential treatment of cognitive impairment. Considering this, a…”
Get full text

Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi by Varela, Marina T., Amaral, Maiara, Romanelli, Maiara M., de Castro Levatti, Erica V., Tempone, Andre G., Fernandes, João Paulo S.

“…Trypanosoma cruzi is the causing agent of Chagas disease, a parasitic infection without efficient treatment for chronic patients. Despite the efforts, no new…”
Get full text

Bioisosteric modification on benzylidene‐carbonyl compounds improved the drug‐likeness and maintained the antifungal activity against Sporothrix brasiliensis by Waller, Stefanie Bressan, Cleff, Marlete Brum, Ripoll, Márcia Kutscher, Meireles, Mário Carlos Araújo, Ferrarini, Márcio, Varela, Marina Themoteo, Fernandes, João Paulo S.

“…Considering the emergence of antifungal resistance on Sporothrix brasiliensis, we aimed to assess new benzylidene‐carbonyl compounds against feline‐borne S…”
Get full text

Coumaric acid analogues inhibit growth and melanin biosynthesis in Cryptococcus neoformans and potentialize amphotericin B antifungal activity by Oliveira, Lidiane, Ferrarini, Márcio, dos Santos, Alexandre Paes, Varela, Marina Themoteo, Corrêa, Isabela Teresa Santos, Tempone, André Gustavo, Melhem, Marcia S.C., Vallim, Marcelo A., Fernandes, João Paulo S., Pascon, Renata C.

“…•Novel coumaric acid analogues with fungal tyrosinase inhibitory activity are described.•These compounds also cause growth arrest and melanization inhibition…”
Get full text

Novel potent vasodilating agents: Evaluation of the activity and potency of LINS01005 and derivatives in rat aorta by Ginoza, Milton, Fernandes, Gustavo A.B., Corrêa, Michelle F., Fernandes, João Paulo S.

“…•LINS01005 is a potent vasodilating agent in rat thoracic aortha.•Compounds are more potent in SHR than Wistar rat's vessels.•N-Phenylpiperazine motif is…”
Get full text