Search Results - "Fernandes, Gustavo W"

Paradigms of Dynamic Control of Thyroid Hormone Signaling by Bianco, Antonio C, Dumitrescu, Alexandra, Gereben, Balázs, Ribeiro, Miriam O, Fonseca, Tatiana L, Fernandes, Gustavo W, Bocco, Barbara M L C

“…Abstract Thyroid hormone (TH) molecules enter cells via membrane transporters and, depending on the cell type, can be activated (i.e., T4 to T3 conversion) or…”
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Neonatal thyroxine activation modifies epigenetic programming of the liver by Fonseca, Tatiana L., Garcia, Tzintzuni, Fernandes, Gustavo W., Nair, T. Murlidharan, Bianco, Antonio C.

“…The type 2 deiodinase (D2) in the neonatal liver accelerates local thyroid hormone triiodothyronine (T3) production and expression of T3-responsive genes. Here…”
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Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice by Bocco, Barbara M. L. C, Werneck-de-Castro, João Pedro, Oliveira, Kelen C, Fernandes, Gustavo W, Fonseca, Tatiana L, Nascimento, Bruna P. P, McAninch, Elizabeth A, Ricci, Esther, Kvárta-Papp, Zsuzsanna, Fekete, Csaba, Bernardi, Maria Martha, Gereben, Balázs, Bianco, Antonio C, Ribeiro, Miriam O

“…Millions of levothyroxine-treated hypothyroid patients complain of impaired cognition despite normal TSH serum levels. This could reflect abnormalities in the…”
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Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity by Fonseca, Tatiana L., Fernandes, Gustavo W., McAninch, Elizabeth A., Bocco, Barbara M. L. C., Abdalla, Sherine M., Ribeiro, Miriam O., Mohácsik, Petra, Fekete, Csaba, Li, Daofeng, Xing, Xiaoyun, Wang, Ting, Gereben, Balázs, Bianco, Antonio C.

“…Thyroid hormone binds to nuclear receptors and regulates gene transcription. Here we report that in mice, at around the first day of life, there is a transient…”
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Tissue-Specific Inactivation of Type 2 Deiodinase Reveals Multilevel Control of Fatty Acid Oxidation by Thyroid Hormone in the Mouse by FONSECA, Tatiana L, WERNECK-DE-CASTRO, Joao Pedro, BIANCO, Antonio C, CASTILLO, Melany, BOCCO, Barbara M. L. C, FERNANDES, Gustavo W, MCANINCH, Elizabeth A, IGNACIO, Daniele L, MOISES, Caio C. S, FERREIRA, Alexandre, BALAZS, Gereben

“…Type 2 deiodinase (D2) converts the prohormone thyroxine (T4) to the metabolically active molecule 3,5,3'-triiodothyronine (T3), but its global inactivation…”
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β1 Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice by Ueta, Cintia B, Fernandes, Gustavo W, Capelo, Luciane P, Fonseca, Tatiane L, Maculan, Flávia D'Angelo, Gouveia, Cecilia H A, Brum, Patrícia C, Christoffolete, Marcelo A, Aoki, Marcelo S, Lancellotti, Carmen L, Kim, Brian, Bianco, Antonio C, Ribeiro, Miriam O

“…Brown adipose tissue (BAT) is predominantly regulated by the sympathetic nervous system (SNS) and the adrenergic receptor signaling pathway. Knowing that a…”
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The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia by Fernandes, Gustavo W., Bocco, Barbara M.L.C., Fonseca, Tatiana L., McAninch, Elizabeth A., Jo, Sungro, Lartey, Lattoya J., O-Sullivan, InSug, Unterman, Terry G., Preite, Nailliw Z., Voigt, Robin M., Forsyth, Christopher B., Keshavarzian, Ali, Sinkó, Richárd, Goldfine, Allison B., Patti, Mary E., Ribeiro, Miriam O., Gereben, Balázs, Bianco, Antonio C.

“…Liver-specific disruption of the type 2 deiodinase gene (Alb-D2KO) results in resistance to both diet-induced obesity and liver steatosis in mice. Here, we…”
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Inactivation of the adrenergic receptor β2 disrupts glucose homeostasis in mice by Fernandes, Gustavo W, Ueta, Cintia B, Fonseca, Tatiane L, Gouveia, Cecilia H A, Lancellotti, Carmen L, Brum, Patrícia C, Christoffolete, Marcelo A, Bianco, Antonio C, Ribeiro, Miriam O

“…Three types of beta adrenergic receptors (ARβ1–3) mediate the sympathetic activation of brown adipose tissue (BAT), the key thermogenic site for mice which is…”
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Human Type 1 Iodothyronine Deiodinase ( DIO1 ) Mutations Cause Abnormal Thyroid Hormone Metabolism by França, Monica M, German, Alina, Fernandes, Gustavo W, Liao, Xiao-Hui, Bianco, Antonio C, Refetoff, Samuel, Dumitrescu, Alexandra M

“…Iodothyronine deiodinase-1 (D1) selenoenzyme regulates the systemic supply of active thyroid hormone (TH). Transient decrease in D1 enzymatic activity is…”
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Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain by Jo, Sungro, Fonseca, Tatiana L, Bocco, Barbara M L C, Fernandes, Gustavo W, McAninch, Elizabeth A, Bolin, Anaysa P, Da Conceição, Rodrigo R, Werneck-de-Castro, Joao Pedro, Ignacio, Daniele L, Egri, Péter, Németh, Dorottya, Fekete, Csaba, Bernardi, Maria Martha, Leitch, Victoria D, Mannan, Naila S, Curry, Katharine F, Butterfield, Natalie C, Bassett, J H Duncan, Williams, Graham R, Gereben, Balázs, Ribeiro, Miriam O, Bianco, Antonio C

“…Levothyroxine (LT4) is a form of thyroid hormone used to treat hypothyroidism. In the brain, T4 is converted to the active form T3 by type 2 deiodinase (D2)…”
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Iodine Deficiency Increases Fat Contribution to Energy Expenditure in Male Mice by Bocco, Barbara M L C, Fernandes, Gustavo W, Fonseca, Tatiana L, Bianco, Antonio C

“…More than a billion people worldwide are at risk of iodine deficiency (ID), with well-known consequences for development of the central nervous system…”
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Higher Caloric Exposure in Critically Ill Patients Transiently Accelerates Thyroid Hormone Activation by McKeever, Liam, Peterson, Sarah J, Lateef, Omar, Freels, Sally, Fonseca, Tatiana L, Bocco, Barbara M L C, Fernandes, Gustavo W, Roehl, Kelly, Nowak, Kristen, Mozer, Marisa, Bianco, Antonio C, Braunschweig, Carol A

“…Abstract Introduction The inflammatory response of critical illness is accompanied by nonthyroidal illness syndrome (NTIS). Feeding has been shown to attenuate…”
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Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis by Fonseca, Tatiana L., Fernandes, Gustavo W., Bocco, Barbara M. L. C., Keshavarzian, Ali, Jakate, Shriram, Donohue, Terrence M., Gereben, Balázs, Bianco, Antonio C.

“…Background A mouse with hepatocyte‐specific deiodinase type II inactivation (Alb‐D2KO) is resistant to diet‐induced obesity, hepatic steatosis, and…”
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Metal Coordinated Poly-Zinc-Liothyronine Provides Stable Circulating Triiodothyronine Levels in Hypothyroid Rats by Da Conceição, Rodrigo R, Fernandes, Gustavo W, Fonseca, Tatiana L, Bocco, Barbara M L C, Bianco, Antonio C

“…Liothyronine (LT3) has limited short-term clinical applications, all of which aim at suppressing thyrotropin (TSH) secretion. A more controversial application…”
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Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes by Werneck-de-Castro, Joao P, Fonseca, Tatiana L, Ignacio, Daniele L, Fernandes, Gustavo W, Andrade-Feraud, Cristina M, Lartey, Lattoya J, Ribeiro, Marcelo B, Ribeiro, Miriam O, Gereben, Balazs, Bianco, Antonio C

“…The type 2 deiodinase (D2) activates the prohormone T4 to T3. D2 is expressed in skeletal muscle (SKM), and its global inactivation (GLOB-D2KO mice) reportedly…”
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Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice by Nascimento, Bruna P P, Bocco, Barbara M L C, Fernandes, Gustavo W, Fonseca, Tatiana L, McAninch, Elizabeth A, Cardoso, Carolina V, Bondan, Eduardo F, Nassif, Renata J, Cysneiros, Roberta M, Bianco, Antonio C, Ribeiro, Miriam O

“…Status epilepticus (SE) is an abnormally prolonged seizure that results from either a failure of mechanisms that terminate seizures or from initiating…”
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Temporal Pole Responds to Subtle Changes in Local Thyroid Hormone Signaling by Marcelino, Cícera P, McAninch, Elizabeth A, Fernandes, Gustavo W, Bocco, Barbara M L C, Ribeiro, Miriam O, Bianco, Antonio C

“…Abstract To study thyroid hormone (TH) signaling in the human brain, we analyzed published microarray data sets of the temporal pole (Brodmann area 38) of 19…”
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Higher Caloric Exposure in Critically III Patients Transiently Accelerates Thyroid Hormone Activation by McKeever, Liam, Peterson, Sarah J, Lateef, Omar, Freels, Sally, Fonseca, Tatiana L, Bocco, Barbara M.L.C, Fernandes, Gustavo W, Roehl, Kelly, Nowak, Kristen, Mozer, Marisa, Bianco, Antonio C, Braunschweig, Carol A

“…Introduction: The inflammatory response of critical illness is accompanied by nonthyroidal illness syndrome (NTIS). Feeding has been shown to attenuate this…”
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Tissue-Specific Inactivation of Type 2 Deiodinase Reveals Multilevel Control of Fatty Acid Oxidation by Thyroid Hormone in the Mouse. Diabetes 2014;63:1594-1604 by Fonseca, T. L., Werneck-De-Castro, J. P., Castillo, M., Bocco, B. M. L. C., Fernandes, G. W., McAninch, E. A., Ignacio, D. L., Moises, C. C. S., Ferreira, A., Gereben, B., Bianco, A. C.

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β(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice by Ueta, Cintia B, Fernandes, Gustavo W, Capelo, Luciane P, Fonseca, Tatiane L, Maculan, Flávia D'Angelo, Gouveia, Cecilia H A, Brum, Patrícia C, Christoffolete, Marcelo A, Aoki, Marcelo S, Lancellotti, Carmen L, Kim, Brian, Bianco, Antonio C, Ribeiro, Miriam O

“…Brown adipose tissue (BAT) is predominantly regulated by the sympathetic nervous system (SNS) and the adrenergic receptor signaling pathway. Knowing that a…”
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