Search Results - "Fernandes, Daphne J"
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Simulation with cells in vitro of tamoxifen treatment in premenopausal breast cancer patients with different CYP2D6 genotypes
Published in British journal of pharmacology (01-12-2014)“…Background and Purpose Tamoxifen is a prodrug that is metabolically activated by 4‐hydroxylation to the potent primary metabolite 4‐hydroxytamoxifen (4OHT) or…”
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Pharmacological Relevance of Endoxifen in a Laboratory Simulation of Breast Cancer in Postmenopausal Patients
Published in JNCI : Journal of the National Cancer Institute (01-10-2014)“…Tamoxifen is metabolically activated via a CYP2D6 enzyme system to the more potent hydroxylated derivatives 4-hydroxytamoxifen and endoxifen. This study…”
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Influence of the Length and Positioning of the Antiestrogenic Side Chain of Endoxifen and 4‑Hydroxytamoxifen on Gene Activation and Growth of Estrogen Receptor Positive Cancer Cells
Published in Journal of medicinal chemistry (12-06-2014)“…Tamoxifen has biologically active metabolites: 4-hydroxytamoxifen (4OHT) and endoxifen. The E-isomers are not stable in solution as Z-isomerization occurs. We…”
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Abstract 4409: The characterization of isomerically stable fixed ring derivatives of tamoxifen metabolites 4-hydroxytamoxifen and 4-hydroxy-N-desmethyltamoxifen (endoxifen) in vitro
Published in Cancer research (Chicago, Ill.) (15-04-2013)“…Tamoxifen is the most widely used agent in the world for antihormonal therapy of Estrogen Receptor (ER)-positive breast cancer for both pre- and postmenopausal…”
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Simulation with cells in vitro of tamoxifen treatment in premenopausal breast cancer patients with different CYP2D 6 genotypes
Published in British journal of pharmacology (01-12-2014)Get full text
Journal Article