First-line paclitaxel and carboplatin in persistent/recurrent or advanced cervical cancer: a retrospective analysis of patients treated at Brazilian National Cancer Institute

Cervical cancer represents the third most commonly diagnosed cancer and the fourth cause of cancer death in women worldwide. In the palliative scenario, the combination of paclitaxel and cisplatin is widely used. Carboplatin is also an active agent in cervical cancer, and its association with paclit...

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Bibliographic Details
Published in:	International journal of gynecological cancer Vol. 23; no. 4; p. 743
Main Authors:	Garces, Álvaro Henrique Ingles, Mora, Paulo Alexandre Ribeiro, Alves, Flávia Vieira Guerra, do Carmo, Claudio Calazan, Grazziotin, Rachele, Fernandes, Anna Cristina Ferrão Mangia, Nogueira-Rodrigues, Angélica, de Melo, Andréia Cristina
Format:	Journal Article
Language:	English
Published:	England 01-05-2013
Subjects:	Adenocarcinoma - drug therapy Adult Aged Aged, 80 and over Antineoplastic Agents, Phytogenic - therapeutic use Brazil Carboplatin - therapeutic use Carcinoma, Squamous Cell - drug therapy Female Humans Middle Aged Neoplasm Recurrence, Local - drug therapy Paclitaxel - therapeutic use Retrospective Studies Uterine Cervical Neoplasms - drug therapy Young Adult Brazil
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Summary:	Cervical cancer represents the third most commonly diagnosed cancer and the fourth cause of cancer death in women worldwide. In the palliative scenario, the combination of paclitaxel and cisplatin is widely used. Carboplatin is also an active agent in cervical cancer, and its association with paclitaxel could represent a well-tolerated, less toxic, and effective therapeutic option. The objective of this study was to evaluate response rate, progression-free survival, overall survival, and toxicity of carboplatin and paclitaxel in first palliative line for cervical cancer. A retrospective search of database at Brazilian National Cancer Institute was performed, and all patients with persistent/recurrent and advanced cervical cancer treated with paclitaxel and carboplatin in first palliative line, between August 2008 and January 2010, were included. A total of 153 women were enrolled. Objective responses were documented in 34.6% (5.2% of complete responses and 29.4% of partial responses). With a median follow-up of 27.8 months, the median progression-free survival was 5.2 months, and the median overall survival was 10.63 months. The most common toxicity was myelosuppression: grades 3 and 4 anemia, neutropenia, and thrombocytopenia observed in 43.0%, 17.8%, and 9.2% of the cases, respectively. Neurotoxicity was presented by 30.7% of the patients. Renal toxicity was detected in 21.9% of the patients, but only 4.0% were grade 3, and none were grade 4. This retrospective study has demonstrated that paclitaxel-carboplatin is an active and well-tolerated regimen for the treatment of advanced cervical cancer.
ISSN:	1525-1438
DOI:	10.1097/IGC.0b013e31828c141d