High plasma levels of endothelin-1 and atrial natriuretic peptide in patients with acute ischemic stroke

The plasma levels of endothelin-1 (ET-1) and atrial natriuretic peptide (ANP) have been measured in 37 patients with acute ischemic stroke, on admission and 3 and 7 days thereafter. The plasma ET-1 levels at the onset of symptoms were about two-fold those observed in age-matched normal volunteers (3...

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Bibliographic Details
Published in:	American journal of hypertension Vol. 7; no. 12; p. 1085
Main Authors:	Estrada, V, Téllez, M J, Moya, J, Fernández-Durango, R, Egido, J, Fernández Cruz, A F
Format:	Journal Article
Language:	English
Published:	United States 01-12-1994
Subjects:	Acute Disease Aged Aged, 80 and over Atrial Natriuretic Factor - blood Brain Ischemia - blood Brain Ischemia - physiopathology Cerebral Infarction - blood Cerebrovascular Disorders - blood Cerebrovascular Disorders - physiopathology Endothelins - blood Female Humans Male Middle Aged Neurologic Examination
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Summary:	The plasma levels of endothelin-1 (ET-1) and atrial natriuretic peptide (ANP) have been measured in 37 patients with acute ischemic stroke, on admission and 3 and 7 days thereafter. The plasma ET-1 levels at the onset of symptoms were about two-fold those observed in age-matched normal volunteers (3.5 +/- 2.26 v 1.54 +/- 0.9 pg/mL, respectively; P < .001). These levels remained significantly elevated during the 7-day study period. The neurologic deficit was assessed daily by Mathew's modified scale (MS). A significant correlation was found between neurologic status on admission and ET-1 plasma values; patients with worse neurologic status (MS < 45 points) had higher ET-1 plasma values than those with better neurologic status (MS > 45 points) (5.4 +/- 2.34 v 3.05 +/- 2.04 pg/mL, respectively, P < .05). The plasma ET-1 values did not correlate either with the site of the infarction or with its primary cause (cardioembolic, lacunar, or atherothrombotic). No significant differences were seen in plasma ET-1 concentrations between patients who eventually died and those who survived the acute event. The plasma ANP were about 18-fold higher in ischemic stroke patients on admission than in controls at admission (110.9 +/- 29.5 v 5.84 +/- 3.96 pg/mL, respectively, P < .01). These values remained significantly elevated on days 3 and 7. There was no correlation between the ANP plasma values and the neurologic status, the site or mechanism of the stroke, or the plasma ET-1 levels. In conclusion, ischemic stroke is associated with marked acute and long-duration increases of ET-1 and ANP.
ISSN:	0895-7061
DOI:	10.1093/ajh/7.12.1085