Search Results - "Fernández‐Montalván, Amaury Ernesto"

BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling‐dependent tumor growth in mouse models by Politz, Oliver, Siegel, Franziska, Bärfacker, Lars, Bömer, Ulf, Hägebarth, Andrea, Scott, William J., Michels, Martin, Ince, Stuart, Neuhaus, Roland, Meyer, Kirstin, Fernández‐Montalván, Amaury Ernesto, Liu, Ningshu, von Nussbaum, Franz, Mumberg, Dominik, Ziegelbauer, Karl

“…The PI3K‐AKT‐mTOR signaling cascade is activated in the majority of human cancers, and its activation also plays a key role in resistance to chemo and targeted…”
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Discovery and Characterization of BAY-184: A New Potent and Selective Acylsulfonamide-Benzofuran In Vivo-Active KAT6AB Inhibitor by ter Laak, Antonius, Hillig, Roman C., Ferrara, Steven J., Korr, Daniel, Barak, Naomi, Lienau, Philip, Herbert, Simon, Fernández-Montalván, Amaury Ernesto, Neuhaus, Roland, Gorjánácz, Mátyás, Puetter, Vera, Badock, Volker, Bone, Wilhelm, Strathdee, Craig, Siegel, Franziska, Schatz, Christoph, Nowak-Reppel, Katrin, Doehr, Olaf, Gradl, Stefan, Hartung, Ingo V., Meyerson, Matthew, Bouché, Léa

“…KAT6A and KAT6B genes are two closely related lysine acetyltransferases that transfer an acetyl group from acetyl coenzyme A (AcCoA) to lysine residues of…”
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Abstract 4714: In vivo efficacy of BET inhibitor BAY 1238097 in preclinical models of melanoma and lung cancer by Klingbeil, Olaf, Haendler, Bernard, Stresemann, Antje, Merz, Claudia, Walter, Annette, Fernández-Montalván, Amaury Ernesto, Ocker, Matthias, Siegel, Stephan, Lejeune, Pascale

“…Bromodomain and extra terminal domain (BET) family proteins which bind to acetylated lysines of histones and regulate gene transcription are promising targets…”
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Abstract 4749: New benzazepine BET-inhibitors with improved oral bioavailability by Schmees, Norbert, Haendler, Bernard, Lejeune, Pascale, Stresemann, Antje, Neuhaus, Roland, Siegel, Stephan, Fernandez-Montalvan, Amaury Ernesto, Weinmann, Hilmar, Gekeler, Volker

“…Bromodomain protein 4 (BRD4), a member of the bromodomain and extra-terminal domain (BET) protein family, binds to acetylated histone tails via its two…”
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Abstract 4539: ATAD2 mediates DNA replication in cancer by Koo, Seong Joo, Fernandez-Montalvan, Amaury Ernesto, Holton, Simon, von Ahsen, Oliver, Badock, Volker, Vittori, Sarah, Ott, Christopher J., Bradner, James E., Gorjanacz, Matyas

“…ATAD2 (ATPase family AAA domain-containing protein 2) is an epigenetic regulator which associates with chromatin through its Bromodomain specialized in…”
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