Search Results - "Fernández‐Marrero, Yuniel"

The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID by Fernández‐Marrero, Yuniel, Bleicken, Stephanie, Das, Kushal Kumar, Bachmann, Daniel, Kaufmann, Thomas, Garcia‐Saez, Ana J.

“…The BCL‐2 family members are key regulators of the intrinsic apoptotic pathway, which is defined by permeabilization of the mitochondrial outer membrane by…”
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BIF-1 inhibits both mitochondrial and glycolytic ATP production: its downregulation promotes melanoma growth by Frangež, Živa, Fernández-Marrero, Yuniel, Stojkov, Darko, Seyed Jafari, S. Morteza, Hunger, Robert E., Djonov, Valentin, Riether, Carsten, Simon, Hans-Uwe

“…Endophilin B1, also known as BAX-interacting protein 1 (BIF-1), is part of the endophilin B protein family, and is a multifunctional protein involved in the…”
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ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1 by Frangež, Živa, Gérard, Deborah, He, Zhaoyue, Gavriil, Marios, Fernández-Marrero, Yuniel, Seyed Jafari, S. Morteza, Hunger, Robert E., Lucarelli, Philippe, Yousefi, Shida, Sauter, Thomas, Sinkkonen, Lasse, Simon, Hans-Uwe

“…Autophagy is a highly conserved cellular process in which intracellular proteins and organelles are sequestered and degraded after the fusion of…”
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A shift from N-glycolyl- to N-acetyl-sialic acid in the GM3 ganglioside impairs tumor development in mouse lymphocytic leukemia cells by Casadesús, Ana Victoria, Fernández-Marrero, Yuniel, Clavell, Marilyn, Gómez, José Alberto, Hernández, Tays, Moreno, Ernesto, López-Requena, Alejandro

“…Humans, in contrast to other mammals, do not synthesize N -glycolyl-neuraminic acid (Neu5Gc) due to a deletion in the gene ( cmah ) encoding the enzyme…”
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Lonely killers: Effector cell- and complement-independent non-proapoptotic cytotoxic antibodies inducing membrane lesions by Fernández-Marrero, Yuniel, López-Requena, Alejandro

“…The majority of the most effective monoclonal antibodies (mAbs) currently in the clinics bind to cancer or immune cells. Classic mechanisms of cell killing by…”
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Characterization of eosinophilic esophagitis variants by clinical, histological, and molecular analyses: A cross‐sectional multi‐center study by Greuter, Thomas, Straumann, Alex, Fernandez‐Marrero, Yuniel, Germic, Nina, Hosseini, Aref, Yousefi, Shida, Simon, Dagmar, Collins, Margaret H., Bussmann, Christian, Chehade, Mirna, Dellon, Evan S., Furuta, Glenn T., Gonsalves, Nirmala, Hirano, Ikuo, Moawad, Fouad J., Biedermann, Luc, Safroneeva, Ekaterina, Schoepfer, Alain M., Simon, Hans‐Uwe

“…Objective Physicians are increasingly confronted with patients presenting with symptoms of esophageal dysfunction resembling eosinophilic esophagitis (EoE),…”
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Antiatherosclerotic Effect of an Antibody That Binds to Extracellular Matrix Glycosaminoglycans by Soto, Yosdel, Acosta, Emilio, Delgado, Livan, Pérez, Arlenis, Falcón, Viviana, Bécquer, María A, Fraga, Ángela, Brito, Víctor, Álvarez, Irene, Griñán, Tania, Fernández-Marrero, Yuniel, López-Requena, Alejandro, Noa, Miriam, Fernández, Eduardo, Vázquez, Ana María

“…OBJECTIVE—Subendothelial retention of proatherogenic lipoproteins by proteoglycans is critical in atherosclerosis. The aim of this study was to characterize…”
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A cytotoxic humanized anti-ganglioside antibody produced in a murine cell line defective of N -glycolylated-glycoconjugates by Fernández-Marrero, Yuniel, Roque-Navarro, Lourdes, Hernández, Tays, Dorvignit, Denise, Molina-Pérez, Marively, González, Addys, Sosa, Katya, López-Requena, Alejandro, Pérez, Rolando, Mateo de Acosta, Cristina

“…Abstract Gangliosides containing the N -glycolyl (NGc) form of sialic acid are tumor-associated antigens and promising candidates for cancer therapy. We…”
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Switching on cytotoxicity by a single mutation at the heavy chain variable region of an anti-ganglioside antibody by Fernández-Marrero, Yuniel, Hernández, Tays, Roque-Navarro, Lourdes, Talavera, Ariel, Moreno, Ernesto, Griñán, Tania, Vázquez, Ana María, de Acosta, Cristina Mateo, Pérez, Rolando, López-Requena, Alejandro

“…Gangliosides are sialic acid-containing glycosphingolipids present in the plasma membrane of most mammalian cells. In humans, the expression of the…”
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Crystal structure of an anti-ganglioside antibody, and modelling of the functional mimicry of its NeuGc-GM3 antigen by an anti-idiotypic antibody by Talavera, Ariel, Eriksson, Agneta, Ökvist, Mats, López-Requena, Alejandro, Fernández-Marrero, Yuniel, Pérez, Rolando, Moreno, Ernesto, Krengel, Ute

“…N-Glycolylated (NeuGc) gangliosides are tumor-specific antigens and as such represent attractive targets for cancer immunotherapy. The chimeric antibody chP3…”
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Non-classical binding of a polyreactive α-type anti-idiotypic antibody to B cells by Hernández, Tays, de Acosta, Cristina Mateo, López-Requena, Alejandro, Moreno, Ernesto, Alonso, Ruby, Fernández-Marrero, Yuniel, Pérez, Rolando

“…Detailed information on the immunological relevance of α-type anti-idiotypic antibodies is lacking after more than 30 years since Jerne postulated his…”
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EGCG Prevents the Onset of an Inflammatory and Cancer-Associated Adipocyte-like Phenotype in Adipose-Derived Mesenchymal Stem/Stromal Cells in Response to the Triple-Negative Breast Cancer Secretome by Gonzalez Suarez, Narjara, Fernandez-Marrero, Yuniel, Torabidastgerdooei, Sima, Annabi, Borhane

“…Triple-negative breast cancer (TNBC) cells secretome induces a pro-inflammatory microenvironment within the adipose tissue, which hosts both mature adipocytes…”
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Brain Regeneration in Drosophila Involves Comparison of Neuronal Fitness by Moreno, Eduardo, Fernandez-Marrero, Yuniel, Meyer, Patricia, Rhiner, Christa

“…Darwinian-like cell selection has been studied during development and cancer [1–11]. Cell selection is often mediated by direct intercellular comparison of…”
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THP-1 cells transduced with CD16A utilize Fcγ receptor I and III in the phagocytosis of IgG-sensitized human erythrocytes and platelets by Gil Gonzalez, Lazaro, Fernandez-Marrero, Yuniel, Norris, Peter Alan Albert, Tawhidi, Zoya, Shan, Yuexin, Cruz-Leal, Yoelys, Won, Kevin Doyoon, Frias-Boligan, Kayluz, Branch, Donald R, Lazarus, Alan H

“…Fc gamma receptors (FcγRs) are critical effector receptors for immunoglobulin G (IgG) antibodies. On macrophages, FcγRs mediate multiple effector functions,…”
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BOK displays cell death‐independent tumor suppressor activity in non‐small‐cell lung carcinoma by Moravcikova, Erika, Krepela, Evzen, Donnenberg, Vera S., Donnenberg, Albert D., Benkova, Kamila, Rabachini, Tatiana, Fernandez‐Marrero, Yuniel, Bachmann, Daniel, Kaufmann, Thomas

“…As the genomic region containing the Bcl‐2‐related ovarian killer (BOK) locus is frequently deleted in certain human cancers, BOK is hypothesized to have a…”
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Loss of BOK Has a Minor Impact on Acetaminophen Overdose-Induced Liver Damage in Mice by Naim, Samara, Fernandez-Marrero, Yuniel, de Brot, Simone, Bachmann, Daniel, Kaufmann, Thomas

“…Acetaminophen (APAP) is one of the most commonly used analgesic and anti-pyretic drugs, and APAP intoxication is one of the main reasons for liver…”
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Is BOK required for apoptosis induced by endoplasmic reticulum stress? by Fernandez-Marrero, Yuniel, Ke, Francine, Echeverry, Nohemy, Bouillet, Philippe, Bachmann, Daniel, Strasser, Andreas, Kaufmann, Thomas

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EGCG inhibits the inflammation and senescence inducing properties of MDA-MB-231 triple-negative breast cancer (TNBC) cells-derived extracellular vesicles in human adipose-derived mesenchymal stem cells by Gonzalez Suarez, Narjara, Fernandez-Marrero, Yuniel, Hébert, Mathieu P. A., Roy, Marie-Eve, Boudreau, Luc H., Annabi, Borhane

“…BackgroundTriple-negative breast cancer (TNBC) cells’ secretome can induce a pro-inflammatory phenotype in human adipose-derived mesenchymal stem cells…”
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Epigallocatechin-3-Gallate Prevents the Acquisition of a Cancer Stem Cell Phenotype in Ovarian Cancer Tumorspheres through the Inhibition of Src/JAK/STAT3 Signaling by Rodriguez Torres, Sahily, Gresseau, Loraine, Benhamida, Meriem, Fernandez-Marrero, Yuniel, Annabi, Borhane

“…Three-dimensional tumorsphere cultures recapitulate the expression of several cancer stem cell (CSC) biomarkers and represent an effective in vitro platform to…”
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Computer-aided design of bromelain and papain covalent immobilization by Cutiño-Avila, Bessy, Gil Pradas, Dayrom, Aragón Abreu, Carlos, Fernández Marrero, Yuniel, Hernández de la Torre, Martha, Salas Sarduy, Emir, Chávez Planes, María De los Ángeles, Guisán Seijas, José Manuel, Díaz Brito, Joaquín, Del Monte-Martínez, Alberto

“…Enzymes as immobilized derivatives have been widely used in Food, Agrochemical, Pharmaceutical and Biotechnological industries. Protein immobilization is…”
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