Search Results - "Fernández, Cecilia A"

The Matrix Metalloproteinase-9/Neutrophil Gelatinase-Associated Lipocalin Complex Plays a Role in Breast Tumor Growth and Is Present in the Urine of Breast Cancer Patients by FERNANDEZ, Cecilia A, LI YAN, LOUIS, Gwendolyn, JIANG YANG, KUTOK, Jeffery L, MOSES, Marsha A

“…Purpose: Having previously shown that the binding of neutrophil gelatinase-associated lipocalin (NGAL) to matrix metalloproteinase-9 (MMP-9) protects this…”
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A novel approach to using matrix metalloproteinases for bladder cancer by Fernández, Cecilia A, Wszolek, Matthew F, Loughlin, Kevin R, Libertino, John A, Summerhayes, Ian C, Shuber, Anthony P

“…Given the steadily growing cancer survivor population, increasing pressure has been placed on more effective clinical approaches and biomarker assays to manage…”
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AsCas12a ultra nuclease facilitates the rapid generation of therapeutic cell medicines by Zhang, Liyang, Zuris, John A., Viswanathan, Ramya, Edelstein, Jasmine N., Turk, Rolf, Thommandru, Bernice, Rube, H. Tomas, Glenn, Steve E., Collingwood, Michael A., Bode, Nicole M., Beaudoin, Sarah F., Lele, Swarali, Scott, Sean N., Wasko, Kevin M., Sexton, Steven, Borges, Christopher M., Schubert, Mollie S., Kurgan, Gavin L., McNeill, Matthew S., Fernandez, Cecilia A., Myer, Vic E., Morgan, Richard A., Behlke, Mark A., Vakulskas, Christopher A.

“…Though AsCas12a fills a crucial gap in the current genome editing toolbox, it exhibits relatively poor editing efficiency, restricting its overall utility…”
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SMOOT libraries and phage-induced directed evolution of Cas9 to engineer reduced off-target activity by Cerchione, Derek, Loveluck, Katherine, Tillotson, Eric L, Harbinski, Fred, DaSilva, Jen, Kelley, Chase P, Keston-Smith, Elise, Fernandez, Cecilia A, Myer, Vic E, Jayaram, Hariharan, Steinberg, Barrett E

“…RNA-guided endonucleases such as Cas9 provide efficient on-target genome editing in cells but may also cleave at off-target loci throughout the genome…”
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Bone morphogenetic protein 1 processes prolactin to a 17-kDa antiangiogenic factor by Ge, Gaoxiang, Fernández, Cecilia A, Moses, Marsha A, Greenspan, Daniel S

“…In addition to classical expression patterns in pituitary and placenta and functions in growth and reproduction, members of the small family of hormones that…”
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Author Correction: AsCas12a ultra nuclease facilitates the rapid generation of therapeutic cell medicines by Zhang, Liyang, Zuris, John A., Viswanathan, Ramya, Edelstein, Jasmine N., Turk, Rolf, Thommandru, Bernice, Rube, H. Tomas, Glenn, Steve E., Collingwood, Michael A., Bode, Nicole M., Beaudoin, Sarah F., Lele, Swarali, Scott, Sean N., Wasko, Kevin M., Sexton, Steven, Borges, Christopher M., Schubert, Mollie S., Kurgan, Gavin L., McNeill, Matthew S., Fernandez, Cecilia A., Myer, Vic E., Morgan, Richard A., Behlke, Mark A., Vakulskas, Christopher A.

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A Noninvasive Multianalyte Urine-Based Diagnostic Assay for Urothelial Cancer of the Bladder in the Evaluation of Hematuria by Karnes, R. Jeffrey, MD, Fernandez, Cecilia A., PhD, Shuber, Anthony P., MS

“…Abstract Objective To test whether a noninvasive urine-based multianalyte diagnostic readout assay that uses protein and DNA biomarkers can risk stratify…”
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Structural and functional uncoupling of the enzymatic and angiogenic inhibitory activities of tissue inhibitor of metalloproteinase-2 (TIMP-2): loop 6 is a novel angiogenesis inhibitor by Fernández, Cecilia A, Butterfield, Catherine, Jackson, Geraldine, Moses, Marsha A

“…Tissue inhibitors of metalloproteinases (TIMPs) regulate tumor growth, progression, and angiogenesis in a variety of experimental cancer models and in human…”
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The Anti-angiogenic Peptide, Loop 6, Binds Insulin-like Growth Factor-1 Receptor by Fernandez, Cecilia A., Roy, Roopali, Lee, Sunyoung, Yang, Jiang, Panigrahy, Dipak, Van Vliet, Krystyn J., Moses, Marsha A.

“…Tissue inhibitors of metalloproteinases (TIMPs), the endogenous inhibitors of matrix metalloproteinases, have been shown to possess biological functions that…”
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Modulation of angiogenesis by tissue inhibitor of metalloproteinase-4 by Fernández, Cecilia A., Moses, Marsha A.

“…Despite the importance of MMP activity in the regulation of angiogenesis, relatively little is known about the role of TIMP-4, the most recently discovered…”
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Oncogenic H-Ras Stimulates Tumor Angiogenesis by Two Distinct Pathways by Arbiser, Jack L., Moses, Marsha A., Fernandez, Cecilia A., Ghiso, Neil, Cao, Yihai, Klauber, Nancy, Frank, David, Brownlee, Michael, Flynn, Evelyn, Parangi, Sareh, Byers, H. Randolph, Folkman, Judah

“…The switch from a quiescent tumor to an invasive tumor is accompanied by the acquisition of angiogenic properties. This phenotypic change likely requires a…”
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Troponin I Is Present in Human Cartilage and Inhibits Angiogenesis by Moses, Marsha A., Wiederschain, Dmitri, Wu, Inmin, Fernandez, Cecilia A., Ghazizadeh, Vahid, Lane, William S., Flynn, Evelyn, Sytkowski, Arthur, Tao, Terence, Langer, Robert

“…Cartilage is an avascular and relatively tumor-resistant tissue. Work from a number of laboratories, including our own, has demonstrated that cartilage is an…”
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Response to “Unexpected mutations after CRISPR–Cas9 editing in vivo” by Wilson, Christopher J, Fennell, Tim, Bothmer, Anne, Maeder, Morgan L, Reyon, Deepak, Cotta-Ramusino, Cecilia, Fernandez, Cecilia A, Marco, Eugenio, Barrera, Luis A, Jayaram, Hariharan, Albright, Charles F, Cox, Gerald F, Church, George M, Myer, Vic E

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Detection and Modulation of DNA Translocations During Multi-Gene Genome Editing in T Cells by Bothmer, Anne, Gareau, Kenneth W, Abdulkerim, Hayat S, Buquicchio, Frank, Cohen, Lucas, Viswanathan, Ramya, Zuris, John A, Marco, Eugenio, Fernandez, Cecilia A, Myer, Vic E, Cotta-Ramusino, Cecilia

“…Multiplexed genome editing with DNA endonucleases has broad application, including for cellular therapies, but chromosomal translocations, natural byproducts…”
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A role for antiangiogenic therapy in breast cancer by Moses, Marsha A, Harper, Jay, Fernández, Cecilia A

“…The success of the angiogenesis inhibitor bevacizumab, the vascular endothelial growth factor antagonist that was recently shown to significantly improve the…”
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Matrilin-1 Is an Inhibitor of Neovascularization by Foradori, Matthew J., Chen, Qian, Fernandez, Cecilia A., Harper, Jay, Li, Xin, Tsang, Paul C.W., Langer, Robert, Moses, Marsha A.

“…In the course of conducting a series of studies whose goal was to discover novel endogenous angiogenesis inhibitors, we have purified matrilin-1 (MATN-1) and…”
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Establishment and biochemical characterization of primary cells of the upper aerodigestive tract by Rickert, Dorothee, Franke, R-P, Fernández, Cecilia A, Kilroy, Susan, Yan, Li, Moses, Marsha A

“…The upper aerodigestive tract, composed of the oral cavity, the pharynx and the esophagus, is a complex system whose components function in both organ-specific…”
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Matrix Metalloproteinase-3 Releases Active Heparin-binding EGF-like Growth Factor by Cleavage at a Specific Juxtamembrane Site by Suzuki, Masashi, Raab, Gerhard, Moses, Marsha A., Fernandez, Cecilia A., Klagsbrun, Michael

“…Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is synthesized as a membrane-anchored precursor that is cleaved to release the soluble…”
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Detection of low frequency FGFR3 mutations in the urine of bladder cancer patients using next-generation deep sequencing by Millholland, John M, Li, Shuqiang, Fernandez, Cecilia A, Shuber, Anthony P

“…Biological fluid-based noninvasive biomarker assays for monitoring and diagnosing disease are clinically powerful. A major technical hurdle for developing…”
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Noninvasive multianalyte diagnostic assay for monitoring bladder cancer recurrence by Shore, Neal D, Fernandez, Cecilia A, Shuber, Anthony P

“…The purpose of this study was to establish the clinical performance of a urine-based assay, called a multianalyte diagnostic readout, in monitoring for bladder…”
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