Search Results - "Ferland, Jean Marie"

Olefin ring-closing metathesis as a powerful tool in drug discovery and development – potent macrocyclic inhibitors of the hepatitis C virus NS3 protease by Tsantrizos, Youla S., Ferland, Jean-Marie, McClory, Andrew, Poirier, Martin, Farina, Vittorio, Yee, Nathan K., Wang, Xiao-jun, Haddad, Nizar, Wei, Xudong, Xu, Jinghua, Zhang, Li

“…Tripeptide dienes composed of three unnatural amino acid residues with numerous chiral centers were efficiently converted to macrocyclic peptides, in high…”
Get full text

Binding Mode Determination of Benzimidazole Inhibitors of the Hepatitis C Virus RNA Polymerase by a Structure and Dynamics Strategy by LaPlante, Steven R., Jakalian, Araz, Aubry, Norman, Bousquet, Yves, Ferland, Jean-Marie, Gillard, James, Lefebvre, Sylvain, Poirier, Martin, Tsantrizos, Youla S., Kukolj, George, Beaulieu, Pierre L.

“…A novel strategy involving NMR, medicinal chemistry, and molecular modeling is described for determining the binding mode of ligands and the binding roles of…”
Get full text

Synthesis of BILN 2061, an HCV NS3 Protease Inhibitor with Proven Antiviral Effect in Humans by Faucher, Anne-Marie, Bailey, Murray D, Beaulieu, Pierre L, Brochu, Christian, Duceppe, Jean-Simon, Ferland, Jean-Marie, Ghiro, Elise, Gorys, Vida, Halmos, Ted, Kawai, Stephen H, Poirier, Martin, Simoneau, Bruno, Tsantrizos, Youla S, Llinàs-Brunet, Montse

“…The synthesis of BILN 2061, an NS3 protease inhibitor with proven antiviral effect in humans, was accomplished in a convergent manner from four building…”
Get full text

RCM of Tripeptide Dienes Containing a Chiral Vinylcyclopropane Moiety:  Impact of Different Ru-Based Catalysts on the Stereochemical Integrity of the Macrocyclic Products by Poirier, Martin, Aubry, Norman, Boucher, Colette, Ferland, Jean-Marie, LaPlante, Steve, Tsantrizos, Youla S

“…Tripeptide dienes containing an (1R,2S)-vinyl aminocyclopropylcarboxylate residue were cyclized to β-strand scaffolds under ring-closing metathesis (RCM)…”
Get full text

Potent Inhibitors of the Hepatitis C Virus NS3 Protease:  Design and Synthesis of Macrocyclic Substrate-Based β-Strand Mimics by Goudreau, Nathalie, Brochu, Christian, Cameron, Dale R, Duceppe, Jean-Simon, Faucher, Anne-Marie, Ferland, Jean-Marie, Grand-Maître, Chantal, Poirier, Martin, Simoneau, Bruno, Tsantrizos, Youla S

“…The virally encoded NS3 protease is essential to the life cycle of the hepatitis C virus (HCV), an important human pathogen causing chronic hepatitis,…”
Get full text

Peptidomimetic Inhibitors of Herpes Simplex Virus Ribonucleotide Reductase with Improved in Vivo Antiviral Activity by Moss, Neil, Beaulieu, Pierre, Duceppe, Jean-Simon, Ferland, Jean-Marie, Garneau, Michel, Gauthier, Jean, Ghiro, Elise, Goulet, Sylvie, Guse, Ingrid, Jaramillo, Jorge, Llinas-Brunet, Montse, Malenfant, Éric, Plante, Raymond, Poirier, Martin, Soucy, Francois, Wernic, Dominik, Yoakim, Christiane, Déziel, Robert

“…We have been investigating the potential of a new class of antiviral compounds. These peptidomimetic derivatives prevent association of the two subunits of…”
Get full text

Binding Mode Determination of Benzimidazole Inhibitors of the Hepatitis C Virus RNA Polymerase by a Structure and Dynamics Strategy by LaPlante, Steven R., Jakalian, Araz, Aubry, Norman, Bousquet, Yves, Ferland, Jean-Marie, Gillard, James, Lefebvre, Sylvain, Poirier, Martin, Tsantrizos, Youla S., Kukolj, George, Beaulieu, Pierre L.

“…Eine neuartige Strategie, die NMR‐Spektroskopie, medizinische Chemie und Molecular Modeling umfasst, diente zur Bestimmung der Bindungsweise von Liganden und…”
Get full text

Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase: a new class of antiviral agents by Moss, Neil, Beaulieu, Pierre, Duceppe, Jean-Simon, Ferland, Jean-Marie, Gauthier, Jean, Ghiro, Elsie, Goulet, Sylvie, Grenier, Louis, Llinas-Brunet, Montse, Plante, Raymond, Wernic, Dominik, Deziel, Robert

“…We have been investigating a new class of antiviral compounds effective against herpes simplex virus (HSV) in vitro and in vivo. Antiviral activity results…”
Get full text

Ureido-Based Peptidomimetic Inhibitors of Herpes Simplex Virus Ribonucleotide Reductase:  An Investigation of Inhibitor Bioactive Conformation by Moss, Neil, Beaulieu, Pierre, Duceppe, Jean-Simon, Ferland, Jean-Marie, Gauthier, Jean, Ghiro, Elise, Goulet, Sylvie, Guse, Ingrid, Llinàs-Brunet, Montse, Plante, Raymond, Plamondon, Louis, Wernic, Dominik, Déziel, Robert

“…We have been investigating peptidomimetic inhibitors of herpes simplex virus (HSV) ribonucleotide reductase (RR). These inhibitors bind to the HSV RR large…”
Get full text

Structure−Activity Study on a Novel Series of Macrocyclic Inhibitors of the Hepatitis C Virus NS3 Protease Leading to the Discovery of BILN 2061 by Llinàs-Brunet, Montse, Bailey, Murray D, Bolger, Gordon, Brochu, Christian, Faucher, Anne-Marie, Ferland, Jean Marie, Garneau, Michel, Ghiro, Elise, Gorys, Vida, Grand-Maître, Chantal, Halmos, Ted, Lapeyre-Paquette, Nicole, Liard, Francine, Poirier, Martin, Rhéaume, Manon, Tsantrizos, Youla S, Lamarre, Daniel

“…From the discovery of competitive hexapeptide inhibitors, potent and selective HCV NS3 protease macrocyclic inhibitors have been identified. Structure−activity…”
Get full text

Herpes simplex virus ribonucleotide reductase subunit association inhibitors: the effect and conformation of beta-alkylated aspartic acid derivatives by Moss, N, Déziel, R, Ferland, J M, Goulet, S, Jones, P J, Leonard, S F, Pitner, T P, Plante, R

“…Incorporating beta-alkylated aspartic acid derivatives into herpes simplex virus ribonucleotide reductase subunit association inhibitors can improve inhibitor…”
Get more information

Potent Inhibitors of the Hepatitis C Virus NS3 Protease: Design and Synthesis of Macrocyclic Substrate-Based [beta]-Strand Mimics by Goudreau, Nathalie, Brochu, Christian, Cameron, Dale R., Duceppe, Jean-Simon, Faucher, Anne-Marie, Ferland, Jean-Marie, Grand-Maître, Chantal, Poirier, Martin, Simoneau, Bruno, Tsantrizos, Youla S.

“…The virally encoded NS3 protease is essential to the life cycle of the hepatitis C virus (HCV), an important human pathogen causing chronic hepatitis,…”
Get full text

RCM of tripeptide dienes containing a chiral vinylcyclopropane moiety : Impact of different ru-based catalysts on the stereochemical integrity of themacrocyclic products by POIRIER, Martin, AUBRY, Norman, BOUCHER, Colette, FERLAND, Jean-Marie, LAPLANTE, Steve, TSANTRIZOS, Youla S

Get full text

Nonpeptidic, Monocharged, Cell Permeable Ligands for the p56lck SH2 Domain by Proudfoot, John R, Betageri, Rajashehar, Cardozo, Mario, Gilmore, Thomas A, Glynn, Susan, Hickey, Eugene R, Jakes, Scott, Kabcenell, Alisa, Kirrane, Thomas M, Tibolla, Annette K, Lukas, Susan, Patel, Usha R, Sharma, Rajiv, Yazdanian, Mehran, Moss, Neil, Beaulieu, Pierre L, Cameron, Dale R, Ferland, Jean-Marie, Gauthier, Jean, Gillard, James, Gorys, Vida, Poirier, Martin, Rancourt, Jean, Wernic, Dominik, Llinas-Brunet, Montse

“…p56lck is a member of the src family of tyrosine kinases and plays a critical role in the signal transduction events that lead to T cell activation. Ligands…”
Get full text

Nonpeptidic, monocharged, cell permeable ligands for the p561ck SH2 domain by PROUDFOOT, John R, BETAGERI, Rajashehar, LUKAS, Susan, PATEL, Usha R, SHARMA, Rajiv, YAZDANIAN, Mehran, MOSS, Neil, BEAULIEU, Pierre L, CAMERON, Dale R, FERLAND, Jean-Marie, GAUTHIER, Jean, GILLARD, James, CARDOZO, Mario, GORYS, Vida, POIRIER, Martin, RANCOURT, Jean, WERNIC, Dominik, LLINAS-BRUNET, Montse, GILMORE, Thomas A, GLYNN, Susan, HICKEY, Eugene R, JAKES, Scott, KABCENELL, Alisa, KIRRANE, Thomas M, TIBOLLA, Annette K

Get full text

Ligands for the Tyrosine Kinase p56 lck SH2 Domain:  Discovery of Potent Dipeptide Derivatives with Monocharged, Nonhydrolyzable Phosphate Replacements by Beaulieu, Pierre L, Cameron, Dale R, Ferland, Jean-Marie, Gauthier, Jean, Ghiro, Elise, Gillard, James, Gorys, Vida, Poirier, Martin, Rancourt, Jean, Wernic, Dominik, Llinas-Brunet, Montse, Betageri, Raj, Cardozo, Mario, Hickey, Eugene R, Ingraham, Richard, Jakes, Scott, Kabcenell, Alisa, Kirrane, Tom, Lukas, Susan, Patel, Usha, Proudfoot, John, Sharma, Rajiv, Tong, Liang, Moss, Neil

“…p56 lck is a member of the src family of tyrosine kinases. Through modular binding units called SH2 domains, p56 lck promotes phosphotyrosine-dependent…”
Get full text

Phosphotyrosine-Containing Dipeptides as High-Affinity Ligands for the p56 lck SH2 Domain by Llinàs-Brunet, Montse, Beaulieu, Pierre L, Cameron, Dale R, Ferland, Jean-Marie, Gauthier, Jean, Ghiro, Elise, Gillard, James, Gorys, Vida, Poirier, Martin, Rancourt, Jean, Wernic, Dominik, Betageri, Raj, Cardozo, Mario, Jakes, Scott, Lukas, Suzanne, Patel, Usha, Proudfoot, John, Moss, Neil

“…Src homology-2 (SH2) domains are noncatalytic motifs containing approximately 100 amino acid residues that are involved in intracellular signal transduction…”
Get full text

Phosphotyrosine-Containing Dipeptides as High-Affinity Ligands for the p56lck SH2 Domain by LLINàS-BRUNET, Montse, BEAULIEU, Pierre L., CAMERON, Dale R., FERLAND, Jean-Marie, GAUTHIER, Jean, GHIRO, Elise, GILLARD, James, GORYS, Vida, POIRIER, Martin, RANCOURT, Jean, WERNIC, Dominik, BETAGERI, Raj, CARDOZO, Mario, JAKES, Scott, LUKAS, Suzanne, PATEL, Usha, PROUDFOOT, John, MOSS, Neil

“…Src homology-2 (SH2) domains are noncatalytic motifs containing approximately 100 amino acid residues that are involved in intracellular signal transduction…”
Get full text

Ligands for the Tyrosine Kinase p56lck SH2 Domain:  Discovery of Potent Dipeptide Derivatives with Monocharged, Nonhydrolyzable Phosphate Replacements by BEAULIEU, Pierre L., CAMERON, Dale R., FERLAND, Jean-Marie, GAUTHIER, Jean, GHIRO, Elise, GILLARD, James, GORYS, Vida, POIRIER, Martin, RANCOURT, Jean, WERNIC, Dominik, LLINAS-BRUNET, Montse, BETAGERI, Raj, CARDOZO, Mario, HICKEY, Eugene R., INGRAHAM, Richard, JAKES, Scott, KABCENELL, Alisa, KIRRANE, Tom, LUKAS, Susan, PATEL, Usha, PROUDFOOT, John, SHARMA, Rajiv, TONG, Liang, MOSS, Neil

“…p56lck is a member of the src family of tyrosine kinases. Through modular binding units called SH2 domains, p56lck promotes phosphotyrosine-dependent…”
Get full text