Search Results - "Ferkany, John W"

Concentrations of Dapivirine in the Rhesus Macaque and Rabbit following Once Daily Intravaginal Administration of a Gel Formulation of [14C]Dapivirine for 7 Days by NUTTALL, Jeremy P, THAKE, Daryl C, LEWIS, Mark G, FERKANY, John W, ROMANO, Joseph W, MITCHNICK, Mark A

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Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors by Ferkany, John W, Zaczek, Robert, Coyle, Joseph T

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The IND application by Ferkany, John W, Williams, Michael

“…Translational biomedical research is often directed to the introduction of a new drug or biologic intended to treat unmet medical need in humans. This unit…”
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Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists by Rzeszotarski, W. Janusz, McPherson, Daniel W, Ferkany, John W, Kinnier, William J, Noronha-Blob, Lalita, Kirkien-Rzeszotarski, Alicja

“…All of the optical isomers of the muscarinic antagonists 3-(1-azabicyclo[2.2.2]octyl) alpha-hydroxy-alpha,alpha-diphenylacetate (3-quinuclidinyl benzilate,…”
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N-Methyl-D -Aspartate Antagonists and Working Memory Performance: Comparison With the Effects of Scopolamine, Propranolol, Diazepam, and Phenylisopropyladenosine by Pontecorvo, Michael J, Clissold, David B, White, Marsha F, Ferkany, John W

“…The effects of the competitive N -methyl- D -aspartate (NMDA) antagonists CPP (5 & 10 mg/kg) and NPC 12626 (25 & 40 mg/kg) and the noncompetitive NMDA…”
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Dextromethorphan inhibits NMDA-induced convulsions by Ferkany, J W, Borosky, S A, Clissold, D B, Pontecorvo, M J

“…Dextromethorphan, its metabolite dextrorphan, phencyclidine, ketamine, MK-801, 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid and…”
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Asymmetric synthesis of a potent and selective competitive NMDA antagonist by Hamilton, Gregory S, Huang, Zhiwen, Yang, Xiao Jing, Patch, Raymond J, Narayanan, B. A, Ferkany, John W

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Possible cerebroprotective and in vivo NMDA antagonist activities of sigma agents by Pontecorvo, M J, Karbon, E W, Goode, S, Clissold, D B, Borosky, S A, Patch, R J, Ferkany, J W

“…The recent finding that ifenprodil binds with high affinity to sigma sites suggests that other sigma agents may have ifenprodil-like cerebroprotectant and…”
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Novel class of amino acid antagonists at non-N-methyl-D-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection by Krogsgaard-Larsen, Povl, Ferkany, John W, Nielsen, Elsebet O, Madsen, Ulf, Ebert, Bjarke, Johansen, Joergen S, Diemer, Nils H, Bruhn, Torben, Beattie, David T, Curtis, David R

“…The isoxazole amino acid 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl) propionic acid (AMPA) (1), which is a highly selective agonist at the AMPA subtype of…”
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The envelope glycoprotein of HIV-1 alters NMDA receptor function by Sweetnam, P M, Saab, O H, Wroblewski, J T, Price, C H, Karbon, E W, Ferkany, J W

“…Human immunodeficiency virus (HIV-1) infection often results in central nervous system (CNS) dysfunction, yet the mechanism(s) of action for HIV-1 in the CNS…”
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Footshock-induced freezing behavior in rats as a model for assessing anxiolytics by Conti, Lisa H., Maciver, Caroline R., Ferkany, John W., Abreu, Mary E.

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Examination of the D2/5-HT2 affinity ratios of resolved 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: an enantioselective approach toward the design of potential atypical antipsychotics by Mewshaw, Richard E, Abreu, Mary E, Silverman, Lisa S, Mathew, Rose M, Tiffany, Carol W, Bailey, Michael A, Karbon, E. William, Ferkany, John W, Kaiser, Carl

“…Enantiomers of several N-substituted 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles were obtained by the resolution of…”
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Drug Discovery for Nervous System Diseases By Franz F. Hefti (Rinat Neuroscience Corporation). John Wiley & Sons, Inc., Hoboken, NJ. 2005. vii + 319 pp. 7 × 10 in. $89.95. ISBN 0-471-46563-1 by Ferkany, John W

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Bradykinin as a Pain Mediator: Receptors are Localized to Sensory Neurons, and Antagonists Have Analgesic Actions by Steranka, Larry R., Manning, Donald C., DeHaas, Christopher J., Ferkany, John W., Borosky, Susan A., Connor, Jane R., Vavrek, Raymond J., Stewart, John M., Snyder, Solomon H.

“…Autoradiographic studies localize [3H]bradykinin receptor binding sites to the substantia gelatinosa, dorsal root, and a subset of small cells in both the…”
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Ifenprodil potently interacts with [3H](+)-3-PPP-labeled sigma binding sites in guinea pig brain membranes by Karbon, E W, Patch, R J, Pontecorvo, M J, Ferkany, J W

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Evidence for direct interactions between the NMDA and glycine recognition sites in brain by Kaplita, P V, Ferkany, J W

“…The interaction between glycine and competitive N-methyl-D-aspartate (NMDA) antagonists was investigated. Glycine (IC50 = 170 nM) partially (approximately 60%)…”
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Bridged .gamma.-carbolines and derivatives possessing selective and combined affinity for 5-HT2 and D2 receptors by Mewshaw, Richard E, Silverman, Lisa S, Mathew, Rose M, Kaiser, Carl, Sherrill, Ronald G, Cheng, Menyan, Tiffany, Carol W, Karbon, E. William, Bailey, Michael A

“…A series of 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles and 6,7,8,9,10,11-hexahydro-7,11-imino-5H-cyclooct[b]indoles was prepared. Structural…”
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Evidence for pharmacologically distinct subsets of GABAB receptors by Scherer, R W, Ferkany, J W, Enna, S J

“…Activation of GABAB receptors augments neurotransmitter-stimulated cyclic AMP accumulation while inhibiting forskolin-mediated second messenger production…”
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NMDA receptor agonists derived from ibotenic acid. Preparation, neuroexcitation and neurotoxicity by Madsen, U, Ferkany, J W, Jones, B E, Ebert, B, Johansen, T N, Holm, T, Krogsgaard-Larsen, P

“…The two heterocyclic aspartic acid and glutamic acid analogues derived from ibotenic acid, (RS)-2-amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid (AMAA)…”
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Anticonvulsant effects of dextrorphan in rats: possible involvement in dextromethorphan-induced seizure protection by Tortella, F C, Ferkany, J W, Pontecorvo, M J

“…The major metabolite of the non-opioid anticonvulsant/antitussive dextromethorphan is dextrorphan. In the present study, the effects of dextrorphan were…”
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