Search Results - "Feringa, Femke M"

Cholesterol and Alzheimer's Disease; From Risk Genes to Pathological Effects by Feringa, Femke M, van der Kant, Rik

“…While the central nervous system compromises 2% of our body weight, it harbors up to 25% of the body's cholesterol. Cholesterol levels in the brain are tightly…”
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Transient Activation of p53 in G2 Phase Is Sufficient to Induce Senescence by Krenning, Lenno, Feringa, Femke M., Shaltiel, Indra A., van den Berg, Jeroen, Medema, René H.

“…DNA damage can result in a transient cell-cycle arrest or lead to permanent cell-cycle withdrawal. Here we show that the decision to irreversibly withdraw from…”
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A limited number of double-strand DNA breaks is sufficient to delay cell cycle progression by van den Berg, Jeroen, G. Manjón, Anna, Kielbassa, Karoline, Feringa, Femke M, Freire, Raimundo, Medema, René H

“…Abstract DNA damaging agents cause a variety of lesions, of which DNA double-strand breaks (DSBs) are the most genotoxic. Unbiased approaches aimed at…”
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MND1 enables homologous recombination in somatic cells primarily outside the context of replication by Koob, Lisa, Friskes, Anoek, Bergen, Louise, Feringa, Femke M., Broek, Bram, Koeleman, Emma S., Beek, Ellis, Schubert, Michael, Blomen, Vincent A., Brummelkamp, Thijn R., Krenning, Lenno, Medema, René H.

“…Faithful and timely repair of DNA double‐strand breaks (DSBs) is fundamental for the maintenance of genomic integrity. Here, we demonstrate that the meiotic…”
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Hypersensitivity to DNA damage in antephase as a safeguard for genome stability by Feringa, Femke M., Krenning, Lenno, Koch, André, van den Berg, Jeroen, van den Broek, Bram, Jalink, Kees, Medema, René H.

“…Activation of the DNA-damage response can lead to the induction of an arrest at various stages in the cell cycle. These arrests are reversible in nature,…”
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An inside job: New roles for ApoE at the lipid droplet by Feringa, Femke M, van der Kant, Rik

“…The secreted ApoE protein is a major regulator of lipid transport between brain cells. In this issue, Windham et al. (https://doi.org/10.1083/jcb.202305003)…”
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An Atypical, Staged Cell Death Pathway Induced by Depletion of SNARE-Proteins MUNC18-1 or Syntaxin-1 by Feringa, Femke M, van Berkel, Annemiek A, Nair, Anushka, Verhage, Matthijs

“…The presynaptic proteins MUNC18-1, syntaxin-1, and SNAP25 drive SNARE-mediated synaptic vesicle fusion and are also required for neuronal viability. Their…”
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Photoactivation of MDM2 Inhibitors: Controlling Protein–Protein Interaction with Light by Hansen, Mickel J, Feringa, Femke M, Kobauri, Piermichele, Szymanski, Wiktor, Medema, René H, Feringa, Ben L

“…Selectivity remains a major challenge in anticancer therapy, which potentially can be overcome by local activation of a cytotoxic drug. Such triggered…”
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CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis by Laine, Anni, Nagelli, Srikar G, Farrington, Caroline, Butt, Umar, Cvrljevic, Anna N, Vainonen, Julia P, Feringa, Femke M, Grönroos, Tove J, Gautam, Prson, Khan, Sofia, Sihto, Harri, Qiao, Xi, Pavic, Karolina, Connolly, Denise C, Kronqvist, Pauliina, Elo, Laura L, Maurer, Jochen, Wennerberg, Krister, Medema, Rene H, Joensuu, Heikki, Peuhu, Emilia, de Visser, Karin, Narla, Goutham, Westermarck, Jukka

“…Basal-like breast cancers (BLBC) are characterized by defects in homologous recombination (HR), deficient mitotic checkpoint, and high-proliferation activity…”
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A FOXO-dependent replication checkpoint restricts proliferation of damaged cells by Hornsveld, Marten, Feringa, Femke M., Krenning, Lenno, van den Berg, Jeroen, Smits, Lydia M.M., Nguyen, Nguyen B.T., Rodríguez-Colman, Maria J., Dansen, Tobias B., Medema, René H., Burgering, Boudewijn M.T.

“…DNA replication is challenged by numerous exogenous and endogenous factors that can interfere with the progression of replication forks. Substantial…”
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AD risk variants in APOE differentially affect lipid metabolism in iPSC derived neurons, astrocytes and microglia by Feringa, Femke M, Elmagd, Amir Abou, Kruijff, Iris Daphne, Heijneman, Jorin, Koppes, Sascha, Mohammed, Yassene, Giera, Martin, van der Kant, Rik

“…Background Despite the clear function of APOE as a lipid carrier it is still unclear how Alzheimer’s disease (AD) risk variants of APOE affect the lipidome of…”
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Multi‐omic profiling of isogenic ApoE3/3 and ApoE4/4 iPSC‐derived astrocytes uncovers altered lipid metabolism and mitochondrial function of ApoE4 astrocytes by Koppes, Sascha, Feringa, Femke M, Robert, Aiko, Kruijff, Iris Daphne, Olivier‐Jimenez, Damien, Erlebach, Lena, Thompson, Leslie M., Kronenberg‐Versteeg, Deborah, Ori, Alessandro, Mohammed, Yassene, Giera, Martin, van der Kant, Rik

“…Background As the main genetic risk factor for AD, glial ApoE4 has been implicated in a number of early disease relevant processes, such as lipid…”
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Multiomics of iPSC‐derived ApoE3‐ and ApoE4 astrocytes and microglia uncovers cell type specific dysregulation of immunometabolism by van der Kant, Rik, Blomberg, Niek, Erlebach, Lena, Feringa, Femke M, Heijneman, Jorin, Koppes, Sascha, Kruijff, Iris Daphne, McQuade, Amanda, Miramontes, Ricardo, Olivier‐Jimenez, Damien, Robert, Aiko, Thompson, Leslie M., Ori, Alessandro, Kronenberg‐Versteeg, Deborah, Mohammed, Yassene, Kampmann, Martin, Giera, Martin

“…Background ApoE4 is the major genetic risk factor for Alzheimer’s disease and the main lipid transporter in brain. How ApoE4 drives AD pathogenesis, and how…”
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