Search Results - "Ferguson, Stephen S"

In Memory of Dr. Marc G. Caron by Salahpour, Ali, Ramsey, Amy J, Ferguson, Stephen S. G

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Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington's pathology in zQ175 mice by Abd-Elrahman, Khaled S, Ferguson, Stephen S G

“…Huntington's disease (HD) is a neurodegenerative disorder caused by a genetic abnormality in the huntingtin gene that leads to a polyglutamine repeat expansion…”
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Characterization of human pregnane X receptor activators identified from a screening of the Tox21 compound library by Lynch, Caitlin, Sakamuru, Srilatha, Huang, Ruili, Niebler, Jake, Ferguson, Stephen S., Xia, Menghang

“…[Display omitted] The pregnane X receptor (PXR; NR1I2) is an important nuclear receptor whose main function is to regulate enzymes within drug metabolism. The…”
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mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntington's disease by Abd-Elrahman, Khaled S, Hamilton, Alison, Hutchinson, Shaunessy R, Liu, Fang, Russell, Ryan C, Ferguson, Stephen S G

“…Huntington's disease (HD) is a neurodegenerative disease caused by an expansion in the huntingtin protein (also called Htt) that induces neuronal cell death…”
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In vitro to in vivo extrapolation for high throughput prioritization and decision making by Bell, Shannon M., Chang, Xiaoqing, Wambaugh, John F., Allen, David G., Bartels, Mike, Brouwer, Kim L.R., Casey, Warren M., Choksi, Neepa, Ferguson, Stephen S., Fraczkiewicz, Grazyna, Jarabek, Annie M., Ke, Alice, Lumen, Annie, Lynn, Scott G., Paini, Alicia, Price, Paul S., Ring, Caroline, Simon, Ted W., Sipes, Nisha S., Sprankle, Catherine S., Strickland, Judy, Troutman, John, Wetmore, Barbara A., Kleinstreuer, Nicole C.

“…In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk. To…”
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3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration by Wang, Hongbing, Brown, Paul C., Chow, Edwin C.Y., Ewart, Lorna, Ferguson, Stephen S., Fitzpatrick, Suzanne, Freedman, Benjamin S., Guo, Grace L., Hedrich, William, Heyward, Scott, Hickman, James, Isoherranen, Nina, Li, Albert P., Liu, Qi, Mumenthaler, Shannon M., Polli, James, Proctor, William R., Ribeiro, Alexandre, Wang, Jian‐Ying, Wange, Ronald L., Huang, Shiew‐Mei

“…Nonclinical testing has served as a foundation for evaluating potential risks and effectiveness of investigational new drugs in humans. However, the current…”
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Minireview: Role of Intracellular Scaffolding Proteins in the Regulation of Endocrine G Protein-Coupled Receptor Signaling by Walther, Cornelia, Ferguson, Stephen S. G

“…The majority of hormones stimulates and mediates their signal transduction via G protein-coupled receptors (GPCRs). The signal is transmitted into the cell due…”
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PDZ Protein Regulation of G Protein-Coupled Receptor Trafficking and Signaling Pathways by Dunn, Henry A, Ferguson, Stephen S G

“…G protein-coupled receptors (GPCRs) contribute to the regulation of every aspect of human physiology and are therapeutic targets for the treatment of numerous…”
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Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment by Wetmore, Barbara A., Wambaugh, John F., Ferguson, Stephen S., Sochaski, Mark A., Rotroff, Daniel M., Freeman, Kimberly, Clewell, Harvey J., Dix, David J., Andersen, Melvin E., Houck, Keith A., Allen, Brittany, Judson, Richard S., Singh, Reetu, Kavlock, Robert J., Richard, Ann M., Thomas, Russell S.

“…High-throughput in vitro toxicity screening can provide an efficient way to identify potential biological targets for chemicals. However, relying on nominal…”
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Hepatic Cytochrome P450 Enzyme Alterations in Humans with Progressive Stages of Nonalcoholic Fatty Liver Disease by FISHER, Craig D, LICKTEIG, Andrew J, AUGUSTINE, Lisa M, RANGER-MOORE, James, JACKSON, Jonathan P, FERGUSON, Stephen S, CHERRINGTON, Nathan J

“…Members of the cytochrome P450 (P450) enzyme families CYP1, CYP2, and CYP3 are responsible for the metabolism of approximately 75% of all clinically relevant…”
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Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer's disease mouse models by Abd-Elrahman, Khaled S, Hamilton, Alison, Vasefi, Maryam, Ferguson, Stephen S G

“…Alzheimer's disease (AD) is characterized by neurotoxicity mediated by the accumulation of beta amyloid (Aβ) oligomers, causing neuronal loss and progressive…”
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Group I metabotropic glutamate receptor signalling and its implication in neurological disease by Ribeiro, Fabiola M, Paquet, Maryse, Cregan, Sean P, Ferguson, Stephen S G

“…Stimulation of Group I metabotropic glutamate receptors (mGluR1 and mGluR5) leads to activation of a wide variety of signalling pathways. mGluRs couple to…”
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Human CYP2C8 is post-transcriptionally regulated by microRNAs 103 and 107 in human liver by Zhang, Shu-Yun, Surapureddi, Sailesh, Coulter, Sherry, Ferguson, Stephen S, Goldstein, Joyce A

“…The CYP2C genes are extensively regulated at the transcriptional stage. The present study shows for the first time that CYP2Cs are also regulated…”
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Comparison of Huntington’s disease phenotype progression in male and female heterozygous FDNQ175 mice by Li, Si Han, Colson, Tash-Lynn L, Chen, Jingwei, Abd-Elrahman, Khaled S, Ferguson, Stephen S. G

“…Abstract Huntington’s Disease (HD) is an inherited autosomal dominant neurodegenerative disorder that leads to progressive motor and cognitive impairment due…”
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VGLUT3 Deletion Rescues Motor Deficits and Neuronal Loss in the zQ175 Mouse Model of Huntington's Disease by Ibrahim, Karim S, El Mestikawy, Salah, Abd-Elrahman, Khaled S, Ferguson, Stephen S G

“…Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease characterized by progressive motor and cognitive impairments, with no…”
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A Dopamine D2 Receptor-DISC1 Protein Complex may Contribute to Antipsychotic-Like Effects by Su, Ping, Li, Shupeng, Chen, Sheng, Lipina, Tatiana V., Wang, Min, Lai, Terence K.Y., Lee, Frankie H.F., Zhang, Hailong, Zhai, Dongxu, Ferguson, Stephen S.G., Nobrega, José N., Wong, Albert H.C., Roder, John C., Fletcher, Paul J., Liu, Fang

“…Current antipsychotic drugs primarily target dopamine D2 receptors (D2Rs), in conjunction with other receptors such as those for serotonin. However, these…”
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Puma Is a Dominant Regulator of Oxidative Stress Induced Bax Activation and Neuronal Apoptosis by Steckley, Diana, Karajgikar, Meera, Dale, Lianne B, Fuerth, Ben, Swan, Patrick, Drummond-Main, Chris, Poulter, Michael O, Ferguson, Stephen S. G, Strasser, Andreas, Cregan, Sean P

“…Oxidative stress has been implicated as a key trigger of neuronal apoptosis in stroke and neurodegenerative conditions such as Alzheimer's disease, Parkinson's…”
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mGluR5 Contribution to Neuropathology in Alzheimer Mice Is Disease Stage-Dependent by Abd-Elrahman, Khaled S, Hamilton, Alison, Albaker, Awatif, Ferguson, Stephen S. G

“…Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease and is characterized by a progressive cognitive decline in affected individuals…”
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The JNK- and AKT/GSK3β- signaling pathways converge to regulate Puma induction and neuronal apoptosis induced by trophic factor deprivation by Ambacher, Kristin K, Pitzul, Kristen B, Karajgikar, Meera, Hamilton, Alison, Ferguson, Stephen S, Cregan, Sean P

“…The AKT, GSK3 and JNK family kinases have been implicated in neuronal apoptosis associated with neuronal development and several neurodegenerative conditions…”
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Metabotropic Glutamate Receptor-Mediated Cell Signaling Pathways Are Altered in a Mouse Model of Huntington's Disease by Ribeiro, Fabiola M, Paquet, Maryse, Ferreira, Lucimar T, Cregan, Tamara, Swan, Patrick, Cregan, Sean P, Ferguson, Stephen S. G

“…Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin protein (Htt). Group I…”
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