Search Results - "Ferguson, Ian D"

Symptomatic Acute Myocarditis in 7 Adolescents After Pfizer-BioNTech COVID-19 Vaccination by Marshall, Mayme, Ferguson, Ian D., Lewis, Paul, Jaggi, Preeti, Gagliardo, Christina, Collins, James Stewart, Shaughnessy, Robin, Caron, Rachel, Fuss, Cristina, Corbin, Kathleen Jo E., Emuren, Leonard, Faherty, Erin, Hall, E. Kevin, Di Pentima, Cecilia, Oster, Matthew E., Paintsil, Elijah, Siddiqui, Saira, Timchak, Donna M., Guzman-Cottrill, Judith A.

“…Trials of coronavirus disease 2019 (COVID-19) vaccination included limited numbers of children, so they may not have detected rare but important adverse events…”
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The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance by Ferguson, Ian D., Patiño-Escobar, Bonell, Tuomivaara, Sami T., Lin, Yu-Hsiu T., Nix, Matthew A., Leung, Kevin K., Kasap, Corynn, Ramos, Emilio, Nieves Vasquez, Wilson, Talbot, Alexis, Hale, Martina, Naik, Akul, Kishishita, Audrey, Choudhry, Priya, Lopez-Girona, Antonia, Miao, Weili, Wong, Sandy W., Wolf, Jeffrey L., Martin, Thomas G., Shah, Nina, Vandenberg, Scott, Prakash, Sonam, Besse, Lenka, Driessen, Christoph, Posey, Avery D., Mullins, R. Dyche, Eyquem, Justin, Wells, James A., Wiita, Arun P.

“…The myeloma surface proteome (surfaceome) determines tumor interaction with the microenvironment and serves as an emerging arena for therapeutic development…”
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Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma by Huang, Hector H., Ferguson, Ian D., Thornton, Alexis M., Bastola, Prabhakar, Lam, Christine, Lin, Yu-Hsiu T., Choudhry, Priya, Mariano, Margarette C., Marcoulis, Makeba D., Teo, Chin Fen, Malato, Julia, Phojanakong, Paul J., Martin, Thomas G., Wolf, Jeffrey L., Wong, Sandy W., Shah, Nina, Hann, Byron, Brooks, Angela N., Wiita, Arun P.

“…Enhancing the efficacy of proteasome inhibitors (PI) is a central goal in myeloma therapy. We proposed that signaling-level responses after PI may reveal new…”
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Unraveling the surface proteomic profile of multiple myeloma to reveal new immunotherapeutic targets and markers of drug resistance by Patiño-Escobar, Bonell, Ferguson, Ian D, Wiita, Arun P

“…The cell surface proteome ("surfaceome") serves as the interface between diseased cells and their local microenvironment. In cancer, this compartment is…”
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Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment by Lam, Christine, Ferguson, Ian D, Mariano, Margarette C, Lin, Yu-Hsiu T, Murnane, Megan, Liu, Hui, Smith, Geoffrey A, Wong, Sandy W, Taunton, Jack, Liu, Jun O, Mitsiades, Constantine S, Hann, Byron C, Aftab, Blake T, Wiita, Arun P

“…The myeloma bone marrow microenvironment promotes proliferation of malignant plasma cells and resistance to therapy. Activation of JAK/STAT signaling is…”
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SARS-CoV-2 B.1.1.7 and B.1.351 spike variants bind human ACE2 with increased affinity by Ramanathan, Muthukumar, Ferguson, Ian D, Miao, Weili, Khavari, Paul A

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T Cell Receptor-Independent, CD31/IL-17A-Driven Inflammatory Axis Shapes Synovitis in Juvenile Idiopathic Arthritis by Ferguson, Ian D, Griffin, Patricia, Michel, Joshua J, Yano, Hiroshi, Gaffen, Sarah L, Mueller, Robert G, Dvergsten, Jeffrey A, Piganelli, Jon D, Rosenkranz, Margalit E, Kietz, Daniel A, Vallejo, Abbe N

“…T cells are considered autoimmune effectors in juvenile idiopathic arthritis (JIA), but the antigenic cause of arthritis remains elusive. Since T cells…”
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Integrated phosphoproteomics and transcriptional classifiers reveal hidden RAS signaling dynamics in multiple myeloma by Lin, Yu-Hsiu T., Way, Gregory P., Barwick, Benjamin G., Mariano, Margarette C., Marcoulis, Makeba, Ferguson, Ian D., Driessen, Christoph, Boise, Lawrence H., Greene, Casey S., Wiita, Arun P.

“…A major driver of multiple myeloma (MM) is thought to be aberrant signaling, yet no kinase inhibitors have proven successful in the clinic. Here, we employed…”
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Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis by Sarin, Vishesh, Yu, Katharine, Ferguson, Ian D., Gugliemini, Olivia, Nix, Matthew A., Hann, Byron, Sirota, Marina, Wiita, Arun P.

“…Multiple myeloma (MM) cell lines are routinely used to model the disease. However, a long-standing question is how well these cell lines truly represent tumor…”
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Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation by Miao, Weili, Porter, Douglas F., Lopez-Pajares, Vanessa, Siprashvili, Zurab, Meyers, Robin M., Bai, Yunhao, Nguyen, Duy T., Ko, Lisa A., Zarnegar, Brian J., Ferguson, Ian D., Mills, Matthew M., Jilly-Rehak, Christie E., Wu, Cheng-Guo, Yang, Yen-Yu, Meyers, Jordan M., Hong, Audrey W., Reynolds, David L., Ramanathan, Muthukumar, Tao, Shiying, Jiang, Sizun, Flynn, Ryan A., Wang, Yinsheng, Nolan, Garry P., Khavari, Paul A.

“…Glucose is a universal bioenergy source; however, its role in controlling protein interactions is unappreciated, as are its actions during…”
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Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma by Ferguson, Ian D, Lin, Yu-Hsiu T, Lam, Christine, Shao, Hao, Tharp, Kevin M, Hale, Martina, Kasap, Corynn, Mariano, Margarette C, Kishishita, Audrey, Patiño Escobar, Bonell, Mandal, Kamal, Steri, Veronica, Wang, Donghui, Phojanakong, Paul, Tuomivaara, Sami T, Hann, Byron, Driessen, Christoph, Van Ness, Brian, Gestwicki, Jason E, Wiita, Arun P

“…Proteasome inhibitor (PI) resistance remains a central challenge in multiple myeloma. To identify pathways mediating resistance, we first mapped…”
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A Case Report of Successful Treatment of Recalcitrant Childhood Localized Scleroderma with Infliximab and Leflunomide by Ferguson, Ian D, Weiser, Peter, Torok, Kathryn S

“…Herein we report successful treatment of an adolescent Caucasian female with severe progressive localized scleroderma (mixed subtype, including generalized…”
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Glucose binds and activates NSUN2 to promote translation and epidermal differentiation by Miao, Weili, Porter, Douglas F, Li, Ya, Meservey, Lindsey M, Yang, Yen-Yu, Ma, Chengjie, Ferguson, Ian D, Tien, Vivian B, Jack, Timothy M, Ducoli, Luca, Lopez-Pajares, Vanessa, Tao, Shiying, Savage, Paul B, Wang, Yinsheng, Khavari, Paul A

“…Abstract Elevations in intracellular glucose concentrations are essential for epithelial cell differentiation by mechanisms that are not fully understood…”
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Psychotropic drug prescribing survey in a Canadian rehabilitation and complex care facility by Warnock, Caroline A, Ferguson, Ian D, Lam, James

“…To describe rates of inpatient prescribing of psychotropic drugs in a rehabilitation and complex continuing care setting. Cross-sectional, observational study…”
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A113: TCR‐independent Activation of T‐cells Through CD31 Triggering as an Etiology of Cytokine Production in Juvenile Idiopathic Arthritis by Ferguson, Ian D., Griffin, Patricia, Michel, Joshua, Kietz, Daniel, Rosenkranz, Margalit, Vallejo, Abbe N.

“…Background/Purpose: JIA is the banner diagnosis for a heterogenous group of rheumatic conditions characterized by local inflammation and destruction of the…”
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Efficacy of N-acetylcysteine and hydration versus placebo and hydration in decreasing contrast-induced renal dysfunction in patients undergoing coronary angiography with or without concomitant percutaneous coronary intervention by Seyon, Rajamalar A., RN, MN, CCN (C), Jensen, Louise A., RN, PhD, Ferguson, Ian A., MD, FRCP (C), Williams, Randall G., MD, FRCP (C)

“…Objective Contrast-induced renal dysfunction is an iatrogenic complication that occurs more frequently in patients with preexisting renal dysfunction. A…”
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