Search Results - "Ferguson, Edwin L"

A Genetic Network Conferring Canalization to a Bistable Patterning System in Drosophila by Gavin-Smyth, Jackie, Wang, Yu-Chiun, Butler, Ian, Ferguson, Edwin L.

“…To achieve the “constancy of the wild-type,” the developing organism must be buffered against stochastic fluctuations and environmental perturbations [1]. This…”
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Niche-associated activation of rac promotes the asymmetric division of Drosophila female germline stem cells by Lu, Wen, Casanueva, M Olivia, Mahowald, Anthony P, Kato, Mihoko, Lauterbach, David, Ferguson, Edwin L

“…Drosophila female germline stem cells (GSCs) reside adjacent to a cellular niche that secretes Bone Morphogenetic Protein (BMP) ligands and anchors the GSCs…”
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Functional evolution of a morphogenetic gradient by Kwan, Chun Wai, Gavin-Smyth, Jackie, Ferguson, Edwin L, Schmidt-Ott, Urs

“…Bone Morphogenetic Proteins (BMPs) pattern the dorsal-ventral axis of bilaterian embryos; however, their roles in the evolution of body plan are largely…”
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Spatial bistability of Dpp-receptor interactions during Drosophila dorsal-ventral patterning by Wang, Y.C, Ferguson, E.L

“…In many developmental contexts, a locally produced morphogen specifies positional information by forming a concentration gradient over a field of cells…”
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Germline stem cell number in the Drosophila ovary is regulated by redundant mechanisms that control Dpp signaling by Casanueva, M Olivia, Ferguson, Edwin L

“…The available experimental data support the hypothesis that the cap cells (CpCs) at the anterior tip of the germarium form an environmental niche for germline…”
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EEL-1, a Hect E3 ubiquitin ligase, controls asymmetry and persistence of the SKN-1 transcription factor in the early C. elegans embryo by Page, Barbara D, Diede, Scott J, Tenlen, Jennifer R, Ferguson, Edwin L

“…During early divisions of the C. elegans embryo, many maternally supplied determinants accumulate asymmetrically, and this asymmetry is crucial for proper cell…”
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Conservation of dorsal-ventral patterning in arthropods and chordates by Ferguson, Edwin L

“…Dorsal—ventral patterning within the ectodermal and mesodermal germ layers of Drosophila and Xenopus embryos is specified by a system of genes that has been…”
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The Xenopus Dorsalizing Factor noggin Ventralizes Drosophila Embryos by Preventing DPP from Activating Its Receptor by Holley, Scott A, Neul, Jeffrey L, Attisano, Liliana, Wrana, Jeffrey L, Sasai, Yoshiki, O'Connor, Michael B, De Robertis, Eddy M, Ferguson, Edwin L

“…noggin is expressed in the Spemann organizer region of the Xenopus embryo and can promote dorsal cell fates within the mesoderm and neural development within…”
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"How Do We Do This at a Distance?!" A Descriptive Study of Remote Undergraduate Research Programs during COVID-19 by Erickson, Olivia A, Cole, Rebecca B, Isaacs, Jared M, Alvarez-Clare, Silvia, Arnold, Jonathan, Augustus-Wallace, Allison, Ayoob, Joseph C, Berkowitz, Alan, Branchaw, Janet, Burgio, Kevin R, Cannon, Charles H, Ceballos, Ruben Michael, Cohen, C. Sarah, Coller, Hilary, Disney, Jane, Doze, Van A, Eggers, Margaret J, Farina, Stacy, Ferguson, Edwin L, Gray, Jeffrey J, Greenberg, Jean T, Hoffmann, Alexander, Jensen-Ryan, Danielle, Kao, Robert M, Keene, Alex C, Kowalko, Johanna E, Lopez, Steven A, Mathis, Camille, Minkara, Mona, Murren, Courtney J, Ondrechen, Mary Jo, Ordoñez, Patricia, Osano, Anne, Padilla-Crespo, Elizabeth, Palchoudhury, Soubantika, Qin, Hong, Ramírez-Lugo, Juan, Reithel, Jennifer, Shaw, Colin A, Smith, Amber, Smith, Rosemary, Summers, Adam P, Tsien, Fern, Dolan, Erin L

“…The COVID-19 pandemic shut down undergraduate research programs across the United States. A group of 23 colleges, universities, and research institutes hosted…”
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Virtually the Same? Evaluating the Effectiveness of Remote Undergraduate Research Experiences by Hess, Riley A, Erickson, Olivia A, Cole, Rebecca B, Isaacs, Jared M, Alvarez-Clare, Silvia, Arnold, Jonathan, Augustus-Wallace, Allison, Ayoob, Joseph C, Berkowitz, Alan, Branchaw, Janet, Burgio, Kevin R, Cannon, Charles H, Ceballos, Ruben Michael, Cohen, C. Sarah, Coller, Hilary, Disney, Jane, Doze, Van A, Eggers, Margaret J, Ferguson, Edwin L, Gray, Jeffrey J, Greenberg, Jean T, Hoffmann, Alexander, Jensen-Ryan, Danielle, Kao, Robert M, Keene, Alex C, Kowalko, Johanna E, Lopez, Steven A, Mathis, Camille, Minkara, Mona, Murren, Courtney J, Ondrechen, Mary Jo, Ordoñez, Patricia, Osano, Anne, Padilla-Crespo, Elizabeth, Palchoudhury, Soubantika, Qin, Hong, Ramírez-Lugo, Juan, Reithel, Jennifer, Shaw, Colin A, Smith, Amber, Smith, Rosemary J, Tsien, Fern, Dolan, Erin L

“…In-person undergraduate research experiences (UREs) promote students' integration into careers in life science research. In 2020, the COVID-19 pandemic…”
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A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin by Holley, Scott A, Jackson, P. David, Sasai, Yoshiki, Lu, Bin, Robertis, Eddy M. De, Hoffmann, F. Michael, Ferguson, Edwin L

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zen and the art of phenotypic maintenance: Canalization of embryonic dorsal-ventral patterning in Drosophila by Gavin-Smyth, Jackie, Ferguson, Edwin L

“…We recently uncovered a novel genetic mechanism that generates the phenotypic uniformity, or canalization, of BMP signaling and cell fate specification during…”
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SMAD signaling drives heart and muscle dysfunction in a Drosophila model of muscular dystrophy by GOLDSTEIN, Jeffery A, KELLY, Sean M, LOPRESTI, Peter P, HEYDEMANN, Ahlke, EARLEY, Judy U, FERGUSON, Edwin L, WOLF, Matthew J, MCNALLY, Elizabeth M

“…Loss-of-function mutations in the genes encoding dystrophin and the associated membrane proteins, the sarcoglycans, produce muscular dystrophy and…”
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Wnt and EGF pathways act together to induce C. elegans male hook development by Yu, Hui, Seah, Adeline, Herman, Michael A., Ferguson, Edwin L., Horvitz, H. Robert, Sternberg, Paul W.

“…Comparative studies of vulva development between Caenorhabditis elegans and other nematode species have provided some insight into the evolution of patterning…”
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The DSmurf Ubiquitin-Protein Ligase Restricts BMP Signaling Spatially and Temporally during Drosophila Embryogenesis by Podos, Steven D., Hanson, Kirsten K., Wang, Yu-Chiun, Ferguson, Edwin L.

“…We identified Drosophila Smurf (DSmurf) as a negative regulator of signaling by the BMP2/4 ortholog DPP during embryonic dorsal-ventral patterning. DSmurf…”
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A positive role for Short gastrulation in modulating BMP signaling during dorsoventral patterning in the Drosophila embryo by Decotto, E, Ferguson, E L

“…Positional information in the dorsoventral axis of the Drosophila embryo is encoded by a BMP activity gradient formed by synergistic signaling between the BMP…”
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Morphogen gradients: new insights from DPP by Podos, Steven D, Ferguson, Edwin L

“…The Drosophila TGFβ family member Decapentaplegic (DPP) has been proposed to function as a morphogen to pattern cell fields in a number of developmental…”
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A stomatin-like protein necessary for mechanosensation in C. elegans by Huang, Mingxia, Gu, Guoqiang, Ferguson, Edwin L, Chalfie, Martin

“…The mec-2 gene is required for the function of a set of six touch receptor neurons in the nematode Caenorhabditis elegans; mec-2 mutants, which are…”
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Spatially Restricted Activation of the SAX Receptor by SCW Modulates DPP/TKV Signaling in Drosophila Dorsal–Ventral Patterning by Neul, Jeffrey L, Ferguson, Edwin L

“…Dorsal–ventral patterning within the embryonic ectoderm of Drosophila requires two TGFβ ligands, DPP and SCW, and two type I TGFβ receptors, TKV and SAX. In…”
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The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4 by Hudson, J B, Podos, S D, Keith, K, Simpson, S L, Ferguson, E L

“…The Transforming Growth Factor-beta superfamily member decapentaplegic (dpp) acts as an extracellular morphogen to pattern the embryonic ectoderm of the…”
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