Search Results - "Ferguson, Christopher M"

Renal scattered tubular-like cells confer protective effects in the stenotic murine kidney mediated by release of extracellular vesicles by Zou, Xiangyu, Kwon, Soon Hyo, Jiang, Kai, Ferguson, Christopher M., Puranik, Amrutesh S., Zhu, Xiangyang, Lerman, Lilach O.

“…To test the hypothesis that intrinsic renal scattered tubular cells (STC-like cells) contribute to repairing injured tubular epithelial cells (TEC) by…”
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Ccl2 deficiency protects against chronic renal injury in murine renovascular hypertension by Kashyap, Sonu, Osman, Mazen, Ferguson, Christopher M., Nath, Meryl C., Roy, Bhaskar, Lien, Karen R., Nath, Karl A., Garovic, Vesna D., Lerman, Lilach O., Grande, Joseph P.

“…Inflammation plays an important role in the pathogenesis of renal and cardiovascular disease in renovascular hypertension (RVH). Ccl2 is an important mediator…”
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A modified two-compartment model for measurement of renal function using dynamic contrast-enhanced computed tomography by Jiang, Kai, Ferguson, Christopher M, Abumoawad, Abdelrhman, Saad, Ahmed, Textor, Stephen C, Lerman, Lilach O

“…To validate and adapt a modified two-compartment model, originally developed for magnetic resonance imaging, for measuring human single-kidney glomerular…”
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Extracellular vesicles released by adipose tissue-derived mesenchymal stromal/stem cells from obese pigs fail to repair the injured kidney by Eirin, Alfonso, Ferguson, Christopher M., Zhu, Xiang-Yang, Saadiq, Ishran M., Tang, Hui, Lerman, Amir, Lerman, Lilach O.

“…•Metabolic syndrome modifies the cargo of stem cell-derived extracellular vesicles.•Vesicles contain microRNAs that target angiogenic pathways in recipient…”
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The Metabolic Syndrome Induces Early Changes in the Swine Renal Medullary Mitochondria by Eirin, Alfonso, MD, Woollard, John R, Ferguson, Christopher M, Jordan, Kyra L, Tang, Hui, MD, PhD, Textor, Stephen C., MD, Lerman, Amir, MD, Lerman, Lilach O., MD, PhD

“…Abstract The metabolic syndrome (MetS) is associated with nutrient surplus and kidney hyperfiltration, accelerating chronic renal failure. Mitochondria can be…”
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Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles Elicit Better Preservation of the Intra-Renal Microvasculature Than Renal Revascularization in Pigs with Renovascular Disease by Ferguson, Christopher M, Farahani, Rahele A, Zhu, Xiang-Yang, Tang, Hui, Jordan, Kyra L, Saadiq, Ishran M, Lerman, Amir, Lerman, Lilach O, Eirin, Alfonso

“…Percutaneous transluminal renal angioplasty (PTRA) confers clinical and mortality benefits in select 'high-risk' patients with renovascular disease (RVD)…”
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Selective intrarenal delivery of mesenchymal stem cell-derived extracellular vesicles attenuates myocardial injury in experimental metabolic renovascular disease by Zhang, Lei, Zhu, Xiang-Yang, Zhao, Yu, Eirin, Alfonso, Liu, Lei, Ferguson, Christopher M., Tang, Hui, Lerman, Amir, Lerman, Lilach O.

“…Extracellular vesicles (EVs) deliver genes and proteins to recipient cells, and mediate paracrine actions of their parent cells. Intrarenal delivery of…”
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Improving Postoperative Acute Kidney Injury Rates Following Primary Total Joint Arthroplasty by Angerett, Nathan R., Yevtukh, Alexander, Ferguson, Christopher M., Kahan, Michael E., Ali, Muzaffar, Hallock, Richard H.

“…Perioperative hip and knee arthroplasty complications remain a significant clinical and financial burden. Our institution has shifted to developing protocols…”
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Renovascular Disease Induces Senescence in Renal Scattered Tubular-Like Cells and Impairs Their Reparative Potency by Chen, Xiao-Jun, Kim, Seo Rin, Jiang, Kai, Ferguson, Christopher M., Tang, Hui, Zhu, Xiang-Yang, Lerman, Amir, Eirin, Alfonso, Lerman, Lilach O.

“…Scattered tubular-like cells (STCs), dedifferentiated renal tubular epithelial cells, contribute to renal self-healing, but severe injury might blunt their…”
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Loss of Renal Peritubular Capillaries in Hypertensive Patients Is Detectable by Urinary Endothelial Microparticle Levels by Sun, In O, Santelli, Adrian, Abumoawad, Abdelrhman, Eirin, Alfonso, Ferguson, Christopher M, Woollard, John R, Lerman, Amir, Textor, Stephen C, Puranik, Amrutesh S, Lerman, Lilach O

“…Hypertension, an important cause of chronic kidney disease, is characterized by peritubular capillary (PTC) loss. Circulating levels of endothelial…”
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Noninvasive Assessment of Renal Fibrosis with Magnetization Transfer MR Imaging: Validation and Evaluation in Murine Renal Artery Stenosis by Jiang, Kai, Ferguson, Christopher M, Ebrahimi, Behzad, Tang, Hui, Kline, Timothy L, Burningham, Tyson A, Mishra, Prassana K, Grande, Joseph P, Macura, Slobodan I, Lerman, Lilach O

“…Purpose To test the utility of magnetization transfer imaging in detecting and monitoring the progression of renal fibrosis in mice with unilateral renal…”
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Reliable Assessment of Swine Renal Fibrosis Using Quantitative Magnetization Transfer Imaging by Jiang, Kai, Ferguson, Christopher M., Grimm, Roger C., Zhu, Xiangyang, Glockner, James F., Lerman, Lilach O.

“…Quantitative magnetization transfer (qMT) is useful for measurement of murine renal fibrosis at high and ultrahigh field strengths. However, its utility at…”
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Quercetin Reverses Cardiac Systolic Dysfunction in Mice Fed with a High-Fat Diet: Role of Angiogenesis by Yu, Shasha, Kim, Seo Rin, Jiang, Kai, Ogrodnik, Mikolaj, Zhu, Xiang Y., Ferguson, Christopher M., Tchkonia, Tamara, Lerman, Amir, Kirkland, James L., Lerman, Lilach O.

“…Global consumption of high-fat diets (HFD) is associated with an increased incidence of cardiometabolic syndrome and cardiac injury, warranting identification…”
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Phase 2a Clinical Trial of Mitochondrial Protection (Elamipretide) During Stent Revascularization in Patients With Atherosclerotic Renal Artery Stenosis by Saad, Ahmed, Herrmann, Sandra M S, Eirin, Alfonso, Ferguson, Christopher M, Glockner, James F, Bjarnason, Haraldur, McKusick, Michael A, Misra, Sanjay, Lerman, Lilach O, Textor, Stephen C

“…Atherosclerotic renal artery stenosis reduces renal blood flow (RBF) and amplifies stenotic kidney hypoxia. Revascularization with percutaneous transluminal…”
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Magnetization Transfer Imaging Predicts Porcine Kidney Recovery After Revascularization of Renal Artery Stenosis by Afarideh, Mohsen, Jiang, Kai, Ferguson, Christopher M., Woollard, John R., Glockner, James F., Lerman, Lilach O.

“…Stenotic kidney (STK) and contralateral kidney magnetization transfer ratios (MTRs; Mt/M0) were measured at 3.0-T magnetic resonance imaging, at offset…”
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Transplanted senescent renal scattered tubular-like cells induce injury in the mouse kidney by Kim, Seo Rin, Jiang, Kai, Ferguson, Christopher M, Tang, Hui, Chen, Xiaojun, Zhu, XiangYang, Hickson, LaTonya J, Tchkonia, Tamara, Kirkland, James L, Lerman, Lilach O

“…Cellular senescence, a permanent arrest of cell proliferation, is characterized by a senescence-associated secretory phenotype (SASP), which reinforces…”
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Effects of obesity on reparative function of human adipose tissue-derived mesenchymal stem cells on ischemic murine kidneys by Klomjit, Nattawat, Conley, Sabena M., Zhu, Xiang Yang, Sadiq, Ishran M., Libai, Yaara, Krier, James D., Ferguson, Christopher M., Jordan, Kyra L., Tang, Hui, Lerman, Amir, Lerman, Lilach O.

“…Introduction Obesity is a health burden that impairs cellular processes. Mesenchymal stem/stromal cells (MSCs) are endowed with reparative properties and can…”
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Tissue hypoxia, inflammation, and loss of glomerular filtration rate in human atherosclerotic renovascular disease by Abumoawad, Abdelrhman, Saad, Ahmed, Ferguson, Christopher M, Eirin, Alfonso, Woollard, John R, Herrmann, Sandra M, Hickson, LaTonya J, Bendel, Emily C, Misra, Sanjay, Glockner, James, Lerman, Lilach O, Textor, Stephen C

“…The relationships between renal blood flow (RBF), tissue oxygenation, and inflammatory injury in atherosclerotic renovascular disease (ARVD) are poorly…”
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Magnetization Transfer Magnetic Resonance Imaging Noninvasively Detects Renal Fibrosis in Swine Atherosclerotic Renal Artery Stenosis at 3.0 T by Jiang, Kai, Ferguson, Christopher M, Woollard, John R, Zhu, Xiangyang, Lerman, Lilach O

“…OBJECTIVESRenal fibrosis is a useful biomarker for diagnosis and evaluation of therapeutic interventions of renal diseases but often requires invasive testing…”
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Mitoprotection attenuates myocardial vascular impairment in porcine metabolic syndrome by Yuan, Fang, Hedayat, Ahmad F, Ferguson, Christopher M, Lerman, Amir, Lerman, Lilach O, Eirin, Alfonso

“…Metabolic syndrome (MetS) leads to cardiac vascular injury, which may reflect in increased retention of endothelial progenitor cells (EPCs). Coronary…”
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