Search Results - "Ferguson, Bradley S"

Non-sirtuin histone deacetylases in the control of cardiac aging by Ferguson, Bradley S, McKinsey, Timothy A

“…Abstract Histone deacetylases (HDACs) catalyze the removal of acetyl-groups from lysine residues within nucelosomal histone tails and thousands of non-histone…”
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Tubulin hyperacetylation is adaptive in cardiac proteotoxicity by promoting autophagy by McLendon, Patrick M, Ferguson, Bradley S, Osinska, Hanna, Bhuiyan, Md Shenuarin, James, Jeanne, McKinsey, Timothy A, Robbins, Jeffrey

“…Proteinopathy causes cardiac disease, remodeling, and heart failure but the pathological mechanisms remain obscure. Mutated αB-crystallin (CryAB ᴿ¹²⁰ᴳ), when…”
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Polyphenols: Novel Signaling Pathways by Ricketts, Marie-Louise, Ferguson, Bradley S

“…Cardiovascular disease (CVD) is currently the leading cause of death globally. The metabolic syndrome (MetS), a clustering of risk factors including…”
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The Role of Histone Acetylation and the Microbiome in Phytochemical Efficacy for Cardiovascular Diseases by Evans, Levi W, Athukorala, Maheshi, Martinez-Guryn, Kristina, Ferguson, Bradley S

“…Cardiovascular diseases (CVD) are the main cause of death worldwide and create a substantial financial burden. Emerging studies have begun to focus on…”
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Impact of reference gene selection for target gene normalization on experimental outcome using real-time qRT-PCR in adipocytes by Ferguson, Bradley S, Nam, Heesun, Hopkins, Robin G, Morrison, Ron F

“…With the current rise in obesity-related morbidities, real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) has become a widely used…”
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Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure by Evans, Levi W, Ferguson, Bradley S

“…Approximately 5.7 million U.S. adults have been diagnosed with heart failure (HF). More concerning is that one in nine U.S. deaths included HF as a…”
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Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression by Angiolilli, Chiara, Grabiec, Aleksander M, Ferguson, Bradley S, Ospelt, Caroline, Malvar Fernandez, Beatriz, van Es, Inge E, van Baarsen, Lisa G M, Gay, Steffen, McKinsey, Timothy A, Tak, Paul P, Baeten, Dominique L, Reedquist, Kris A

“…Epigenetic modifications play an important role in the regulation of gene transcription and cellular function. Here, we examined if pro-inflammatory factors…”
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Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA by Stratton, Matthew S., Lin, Charles Y., Anand, Priti, Tatman, Philip D., Ferguson, Bradley S., Wickers, Sean T., Ambardekar, Amrut V., Sucharov, Carmen C., Bradner, James E., Haldar, Saptarsi M., McKinsey, Timothy A.

“…BRD4 governs pathological cardiac gene expression by binding acetylated chromatin, resulting in enhanced RNA polymerase II (Pol II) phosphorylation and…”
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Obesity-mediated regulation of cardiac protein acetylation: parallel analysis of total and acetylated proteins via TMT-tagged mass spectrometry by Romanick, Samantha S, Ulrich, Craig, Schlauch, Karen, Hostler, Andrew, Payne, Jordanna, Woolsey, Rebekah, Quilici, David, Feng, Yumei, Ferguson, Bradley S

“…Lysine residues undergo diverse and reversible post-translational modifications (PTMs). Lysine acetylation has traditionally been studied in the epigenetic…”
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Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy by Ferguson, Bradley S., Harrison, Brooke C., Jeong, Mark Y., Reid, Brian G., Wempe, Michael F., Wagner, Florence F., Holson, Edward B., McKinsey, Timothy A.

“…Cardiac hypertrophy is a strong predictor of morbidity and mortality in patients with heart failure. Small molecule histone deacetylase (HDAC) inhibitors have…”
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Divergent and Overlapping Roles for Selected Phytochemicals in the Regulation of Pathological Cardiac Hypertrophy by Evans, Levi, Shen, Yiqui, Bender, Abigail, Burnett, Leah E, Li, Musheng, Habibian, Justine S, Zhou, Tong, Ferguson, Bradley S

“…Plant-based foods, like fruits, vegetables, whole grains, legumes, nuts, seeds and other foodstuffs, have been deemed as heart healthy. The chemicals within…”
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DUSP5 functions as a feedback regulator of TNFα-induced ERK1/2 dephosphorylation and inflammatory gene expression in adipocytes by Habibian, Justine S., Jefic, Mitra, Bagchi, Rushita A., Lane, Robert H., McKnight, Robert A., McKinsey, Timothy A., Morrison, Ron F., Ferguson, Bradley S.

“…Adipose tissue inflammation is a central pathological element that regulates obesity-mediated insulin resistance and type II diabetes. Evidence demonstrates…”
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Modulation of IL‐27 in adipocytes during inflammatory stress by Nam, Heesun, Ferguson, Bradley S., Stephens, Jacqueline M., Morrison, Ron F.

“…Objective While it is well established that adipose tissue‐derived inflammation plays an important role in the pathogenic mechanisms linking obesity with…”
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MicroRNA Biogenesis, Gene Regulation Mechanisms, and Availability in Foods by de Mello, Amilton S, Ferguson, Bradley S, Shebs-Maurine, Erica L, Giotto, Francine M

“…MicroRNAs (miRNAs) are small, non-coding RNAs that control gene expression by degrading or repressing mRNA translation into proteins. Research recently…”
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Emodin Inhibited Pathological Cardiac Hypertrophy in Response to Angiotensin-Induced Hypertension and Altered the Gut Microbiome by Evans, Levi, Price, Tori, Hubert, Nathaniel, Moore, Julia, Shen, Yiqui, Athukorala, Maheshi, Frese, Steven, Martinez-Guryn, Kristina, Ferguson, Bradley S.

“…Objective: Evidence suggests that food bioactives affect the epigenome to prevent pathological cardiac hypertrophy. Recently, we showed that emodin, an…”
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Influence of previous plane of nutrition on molecular mechanisms regulating the expression of urea and water metabolism related genes in the rumen and kidney of finishing crossbred Angus steers by Moreira da Silva, Aghata E, Franco, Arturo Macias, Ferguson, Bradley S, Fonseca, Mozart A

“…This study aimed to understand how molecular mechanisms controlling water and urea metabolism at the finishing phase can be affected by previous plane of…”
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Impact of obesity on IL-12 family gene expression in insulin responsive tissues by Nam, Heesun, Ferguson, Bradley S, Stephens, Jacqueline M, Morrison, Ron F

“…Mounting evidence has established a role for chronic inflammation in the development of obesity-induced insulin resistance, as genetic ablation of…”
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Curcumin Inhibits 3T3-L1 Preadipocyte Proliferation by Mechanisms Involving Post-transcriptional p27 Regulation by Ferguson, Bradley S, Nam, Heesun, Morrison, Ron F

“…Previous reports from our lab have shown that Skp2 is necessary for p27 degradation and cell cycle progression during adipocyte differentiation. Data presented…”
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The Crosstalk between Acetylation and Phosphorylation: Emerging New Roles for HDAC Inhibitors in the Heart by Habibian, Justine, Ferguson, Bradley S

“…Approximately five million United States (U.S.) adults are diagnosed with heart failure (HF), with eight million U.S. adults projected to suffer from HF by…”
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Dietary natural products as epigenetic modifiers in aging-associated inflammation and disease by Evans, Levi W, Stratton, Matthew S, Ferguson, Bradley S

“…Covering: up to 2020Chronic, low-grade inflammation is linked to aging and has been termed "inflammaging". Inflammaging is considered a key contributor to the…”
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