Search Results - "Ferguson, Andrew D."

Structural Basis of Substrate Methylation and Inhibition of SMYD2 by Ferguson, Andrew D., Larsen, Nicholas A., Howard, Tina, Pollard, Hannah, Green, Isabelle, Grande, Christie, Cheung, Tony, Garcia-Arenas, Renee, Cowen, Scott, Wu, Jiaquan, Godin, Robert, Chen, Huawei, Keen, Nicholas

“…Protein lysine methyltransferases are important regulators of epigenetic signaling. These enzymes catalyze the transfer of donor methyl groups from…”
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Structural basis of CX-4945 binding to human protein kinase CK2 by Ferguson, Andrew D., Sheth, Payal R., Basso, Andrea D., Paliwal, Sunil, Gray, Kimberly, Fischmann, Thierry O., Le, Hung V.

“…Protein kinase CK2 (CK2), a constitutively active serine/threonine kinase, is involved in a variety of roles essential to the maintenance of cellular…”
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Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases by Dakin, Les A., Block, Michael H., Chen, Huawei, Code, Erin, Dowling, James E., Feng, Xiaomei, Ferguson, Andrew D., Green, Isabelle, Hird, Alexander W., Howard, Tina, Keeton, Erika K., Lamb, Michelle L., Lyne, Paul D., Pollard, Hannah, Read, Jon, Wu, Allan J., Zhang, Tao, Zheng, Xiaolan

“…Novel substituted benzylidene-1,3-thiazolidine-2,4-diones (TZDs) have been identified as potent and highly selective inhibitors of the PIM kinases. The…”
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Crystal Structure of Inhibitor-Bound Human 5-Lipoxygenase: Activating Protein by Ferguson, Andrew D., McKeever, Brian M., Xu, Shihua, Wisniewski, Douglas, Miller, Douglas K., Yamin, Ting-Ting, Spencer, Robert H., Chu, Lin, Ujjainwalla, Feroze, Cunningham, Barry R., Evans, Jilly F., Becker, Joseph W.

“…Leukotrienes are proinflammatory products of arachidonic acid oxidation by 5-lipoxygenase that have been shown to be involved in respiratory and cardiovascular…”
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NMR Structures of the Selenoproteins Sep15 and SelM Reveal Redox Activity of a New Thioredoxin-like Family by Ferguson, Andrew D., Labunskyy, Vyacheslav M., Fomenko, Dmitri E., Araç, Demet, Chelliah, Yogarany, Amezcua, Carlos A., Rizo, Josep, Gladyshev, Vadim N., Deisenhofer, Johann

“…Selenium has significant health benefits, including potent cancer prevention activity and roles in immune function and the male reproductive system…”
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Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome by Olivier, Nelson B., Altman, Roger B., Noeske, Jonas, Basarab, Gregory S., Code, Erin, Ferguson, Andrew D., Gao, Ning, Huang, Jian, Juette, Manuel F., Livchak, Stephania, Miller, Matthew D., Prince, D. Bryan, Cate, Jamie H. D., Buurman, Ed T., Blanchard, Scott C.

“…Significance The identification of negamycin’s binding site within helix 34 of the small subunit head domain and the elucidation of its mechanism of action…”
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Biochemical Characterization of Human SET and MYND Domain-Containing Protein 2 Methyltransferase by Wu, Jiaquan, Cheung, Tony, Grande, Christie, Ferguson, Andrew D, Zhu, Xiahui, Theriault, Kelly, Code, Erin, Birr, Cynthia, Keen, Nick, Chen, Huawei

“…SET and MYND domain-containing protein 2 (SMYD2) is a protein lysine methyltransferase that catalyzes the transfer of methyl groups from S-adenosylmethionine…”
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Structural Basis of Gating by the Outer Membrane Transporter FecA by Ferguson, Andrew D., Chakraborty, Ranjan, Smith, Barbara S., Esser, Lothar, van der Helm, Dick, Deisenhofer, Johann

“…Siderophore-mediated acquisition systems facilitate iron uptake. We present the crystallographic structure of the integral outer membrane receptor FecA from…”
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Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy by Huyghe, Deborah, Denninger, Andrew R, Voss, Caroline M, Frank, Pernille, Gao, Ning, Brandon, Nicholas, Waagepetersen, Helle S, Ferguson, Andrew D, Pangalos, Menelas, Doig, Peter, Moss, Stephen J

“…The astrocyte-specific enzyme glutamine synthetase (GS), which catalyzes the amidation of glutamate to glutamine, plays an essential role in supporting…”
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Signal transduction pathway of TonB-dependent transporters by Ferguson, Andrew D, Amezcua, Carlos A, Halabi, Najeeb M, Chelliah, Yogarany, Rosen, Michael K, Ranganathan, Rama, Deisenhofer, Johann

“…Transcription of the ferric citrate import system is regulated by ferric citrate binding to the outer membrane transporter FecA. A signal indicating…”
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The ER protein folding sensor UDP-glucose glycoprotein-glucosyltransferase modifies substrates distant to local changes in glycoprotein conformation by Thomas, David Y, Taylor, Sean C, Ferguson, Andrew D, Bergeron, John J M

“…We present in vitro data that explain the recognition mechanism of misfolded glycoproteins by UDP-glucose glycoprotein-glucosyltransferase (UGGT). The…”
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A Novel Cysteine-rich Domain of Sep15 Mediates the Interaction with UDP-glucose:Glycoprotein Glucosyltransferase by Labunskyy, Vyacheslav M., Ferguson, Andrew D., Fomenko, Dmitri E., Chelliah, Yogarany, Hatfield, Dolph L., Gladyshev, Vadim N.

“…Selenium is an essential trace element with potent cancer prevention activity in mammals. The 15-kDa selenoprotein (Sep15) has been implicated in the…”
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Discovery of aminopiperidine-based Smac mimetics as IAP antagonists by Hennessy, Edward J., Saeh, Jamal C., Sha, Li, MacIntyre, Terry, Wang, Haiyun, Larsen, Nicholas A., Aquila, Brian M., Ferguson, Andrew D., Laing, Naomi M., Omer, Charles A.

“…A series of structurally unique Smac mimetics that act as antagonists of inhibitor of apoptosis proteins (IAPs) has been discovered. While most previously…”
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A conserved structural motif for lipopolysaccharide recognition by procaryotic and eucaryotic proteins by D Ferguson, Andrew, Welte, Wolfram, Hofmann, Eckhard, Lindner, Buko, Holst, Otto, Coulton, James W, Diederichs, Kay

“…Background: Lipopolysaccharide (LPS), a lipoglycan from the outer membrane of Gram-negative bacteria, is an immunomodulatory molecule that stimulates the…”
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Structural approaches to obtain kinase selectivity by Norman, Richard A, Toader, Dorin, Ferguson, Andrew D

“…One of the grand challenges in kinase drug discovery is the design of small-molecule inhibitors with selectivity profiles that will ultimately be efficacious…”
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Analysis of the Substrate Specificity of the SMYD2 Protein Lysine Methyltransferase and Discovery of Novel Non‐Histone Substrates by Weirich, Sara, Schuhmacher, Maren Kirstin, Kudithipudi, Srikanth, Lungu, Cristiana, Ferguson, Andrew D., Jeltsch, Albert

“…The SMYD2 protein lysine methyltransferase methylates various histone and non‐histone proteins and is overexpressed in several cancers. Using peptide arrays,…”
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Rational design of a new antibiotic class for drug-resistant infections by Durand-Reville, Thomas F., Miller, Alita A., O’Donnell, John P., Wu, Xiaoyun, Sylvester, Mark A., Guler, Satenig, Iyer, Ramkumar, Shapiro, Adam B., Carter, Nicole M., Velez-Vega, Camilo, Moussa, Samir H., McLeod, Sarah M., Chen, April, Tanudra, Angela M., Zhang, Jing, Comita-Prevoir, Janelle, Romero, Jan A., Huynh, Hoan, Ferguson, Andrew D., Horanyi, Peter S., Mayclin, Stephen J., Heine, Henry S., Drusano, George L., Cummings, Jason E., Slayden, Richard A., Tommasi, Ruben A.

“…The development of new antibiotics to treat infections caused by drug-resistant Gram-negative pathogens is of paramount importance as antibiotic resistance…”
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Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies by Barlaam, Bernard, Casella, Robert, Cidado, Justin, Cook, Calum, De Savi, Chris, Dishington, Allan, Donald, Craig S, Drew, Lisa, Ferguson, Andrew D, Ferguson, Douglas, Glossop, Steve, Grebe, Tyler, Gu, Chungang, Hande, Sudhir, Hawkins, Janet, Hird, Alexander W, Holmes, Jane, Horstick, James, Jiang, Yun, Lamb, Michelle L, McGuire, Thomas M, Moore, Jane E, O’Connell, Nichole, Pike, Andy, Pike, Kurt G, Proia, Theresa, Roberts, Bryan, San Martin, Maryann, Sarkar, Ujjal, Shao, Wenlin, Stead, Darren, Sumner, Neil, Thakur, Kumar, Vasbinder, Melissa M, Varnes, Jeffrey G, Wang, Jianyan, Wang, Lei, Wu, Dedong, Wu, Liangwei, Yang, Bin, Yao, Tieguang

“…A CDK9 inhibitor having short target engagement would enable a reduction of Mcl-1 activity, resulting in apoptosis in cancer cells dependent on Mcl-1 for…”
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Development of a Novel B‑Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6 by McCoull, William, Cheung, Tony, Anderson, Erica, Barton, Peter, Burgess, Jonathan, Byth, Kate, Cao, Qing, Castaldi, M. Paola, Chen, Huawei, Chiarparin, Elisabetta, Carbajo, Rodrigo J, Code, Erin, Cowan, Suzanna, Davey, Paul R, Ferguson, Andrew D, Fillery, Shaun, Fuller, Nathan O, Gao, Ning, Hargreaves, David, Howard, Martin R, Hu, Jun, Kawatkar, Aarti, Kemmitt, Paul D, Leo, Elisabetta, Molina, Daniel M, O’Connell, Nichole, Petteruti, Philip, Rasmusson, Timothy, Raubo, Piotr, Rawlins, Philip B, Ricchiuto, Piero, Robb, Graeme R, Schenone, Monica, Waring, Michael J, Zinda, Michael, Fawell, Stephen, Wilson, David M

“…B-cell lymphoma 6 (BCL6) inhibition is a promising mechanism for treating hematological cancers but high quality chemical probes are necessary to evaluate its…”
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A novel strain of lumpy skin disease virus causes clinical disease in cattle in Hong Kong by Flannery, John, Shih, Barbara, Haga, Ismar R., Ashby, Martin, Corla, Amanda, King, Simon, Freimanis, Graham, Polo, Noemi, Tse, Anne Ching‐nga, Brackman, Christopher J., Chan, Jason, Pun, Patrick, Ferguson, Andrew D., Law, Andy, Lycett, Samantha, Batten, Carrie, Beard, Philippa M.

“…Lumpy skin disease virus (LSDV) is an emerging poxviral pathogen of cattle that is currently spreading throughout Asia. The disease situation is of high…”
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