Search Results - "Ferenc, G."

Discovery of LHRH and development of LHRH analogs for prostate cancer treatment by Schally, Andrew V., Block, Norman L., Rick, Ferenc G.

“…The discovery, isolation, elucidation of structure, synthesis, and initial testing of the neuropeptide hypothalamic luteinizing hormone‐releasing hormone…”
Get full text

Antagonists of growth hormone-releasing hormone inhibit proliferation induced by inflammation in prostatic epithelial cells by Popovics, Petra, Schally, Andrew V., Salgueiro, Luis, Kovacs, Krisztina, Rick, Ferenc G.

“…The etiology of benign prostatic hyperplasia (BPH) is multifactorial, and chronic inflammation plays a pivotal role in its pathogenesis. Growth…”
Get full text

Growth hormone‐releasing hormone antagonists reduce prostatic enlargement and inflammation in carrageenan‐induced chronic prostatitis by Popovics, Petra, Cai, Renzhi, Sha, Wei, Rick, Ferenc G., Schally, Andrew V.

“…Background Inflammation plays a key role in the etiology of benign prostatic hyperplasia (BPH) through multiple pathways involving the stimulation of…”
Get full text

Bench-to-bedside development of agonists and antagonists of luteinizing hormone–releasing hormone for treatment of advanced prostate cancer by Rick, Ferenc G., M.D., Ph.D, Schally, Andrew V., Ph.D., M.D.h.c

“…Abstract Background Androgen deprivation therapy (ADT) has been the standard of care for treating patients with hormone-sensitive advanced prostate cancer…”
Get full text

Targeted therapy in advanced metastatic colorectal cancer: Current concepts and perspectives by Hohla, Florian, Winder, Thomas, Greil, Richard, Rick, Ferenc G, Block, Norman L, Schally, Andrew V

“…The introduction of new cytotoxic substances as well as agents that target vascular endothelial growth factor(VEGF)and epidermal growth factor…”
Get full text

Targeting of Peptide Cytotoxins to LHRH Receptors For Treatment of Cancer by Engel, Jorg B, Tinneberg, Hans-Rudolf, Rick, Ferenc G, Berkes, Enniko, Schally, Andrew V

“…Receptors for LHRH (luteinizing hormone-releasing hormone) are expressed in about 80% of human endometrial, ovarian and prostate cancers and are also found in…”
Get more information

The potential role of follicle-stimulating hormone in the cardiovascular, metabolic, skeletal, and cognitive effects associated with androgen deprivation therapy by Crawford, E. David, M.D, Schally, Andrew V., Ph.D., M.Dhc. (Multi), D.Sc., hc, Pinthus, Jehonathan H., M.D., Ph.D, Block, Norman L., M.D, Rick, Ferenc G., M.D., Ph.D, Garnick, Marc B., M.D, Eckel, Robert H., M.D, Keane, Thomas E., M.B.B.Ch., F.R.C.S.I., F.A.C.S, Shore, Neal D., M.D., F.A.C.S., C.P.I, Dahdal, David N., M.S., Ph.D, Beveridge, Thomas J.R., M.Sc., Ph.D, Marshall, Dennis C., R.N., M.S., Ph.D

“…Abstract Purpose To explore how follicle-stimulating hormone (FSH) may contribute to cardiovascular, metabolic, skeletal, and cognitive events in men treated…”
Get full text

Antagonists of growth hormone-releasing hormone inhibit growth of androgen-independent prostate cancer through inactivation of ERK and Akt kinases by Rick, Ferenc G., Schally, Andrew V., Szalontay, Luca, Block, Norman L., Szepeshazi, Karoly, Nadji, Mehrdad, Zarandi, Marta, Hohla, Florian, Buchholz, Stefan, Seitz, Stephan

“…The management of castration-resistant prostate cancer (CRPC) presents a clinical challenge because of limitations in efficacy of current therapies. Novel…”
Get full text

Preclinical efficacy of growth hormone-releasing hormone antagonists for androgen-dependent and castration-resistant human prostate cancer by Fahrenholtz, Cale D., Rick, Ferenc G., Garcia, Maria I., Zarandi, Marta, Cai, Ren-Zhi, Block, Norman L., Schally, Andrew V., Burnstein, Kerry L.

“…Advanced hormone-sensitive prostate cancer responds to androgen-deprivation therapy (ADT); however, therapeutic options for recurrent castration-resistant…”
Get full text

Antagonists of growth hormone-releasing hormone (GHRH) reduce prostate size in experimental benign prostatic hyperplasia by Rick, Ferenc G, Schally, Andrew V, Block, Norman L, Nadji, Mehrdad, Szepeshazi, Karoly, Zarandi, Marta, Vidaurre, Irving, Perez, Roberto, Halmos, Gabor, Szalontay, Luca

“…Growth hormone-releasing hormone (GHRH), a hypothalamic polypeptide, acts as a potent autocrine/paracrine growth factor in many cancers. Benign prostatic…”
Get full text

Triple negative breast cancers express receptors for LHRH and are potential therapeutic targets for cytotoxic LHRH-analogs, AEZS 108 and AEZS 125 by Seitz, Stephan, Buchholz, Stefan, Schally, Andrew Victor, Weber, Florian, Klinkhammer-Schalke, Monika, Inwald, Elisabeth C, Perez, Roberto, Rick, Ferenc G, Szalontay, Luca, Hohla, Florian, Segerer, Sabine, Kwok, Chui Wai, Ortmann, Olaf, Engel, Jörg Bernhard

“…Triple negative breast cancer (TNBC) is a distinct subtype of breast cancer burdened with a dismal prognosis due to the lack of effective therapeutic agents…”
Get full text

Synthesis and structure-activity studies on novel analogs of human growth hormone releasing hormone (GHRH) with enhanced inhibitory activities on tumor growth by Zarandi, Marta, Cai, Renzhi, Kovacs, Magdolna, Popovics, Petra, Szalontay, Luca, Cui, Tengjiao, Sha, Wei, Jaszberenyi, Miklos, Varga, Jozsef, Zhang, XianYang, Block, Norman L., Rick, Ferenc G., Halmos, Gabor, Schally, Andrew V.

“…•We report synthesis of new GHRH analogs with increased anticancer activity.•Incorporation of pentafluoro Phe and Orn12,21 into GHRH analogs augments antitumor…”
Get full text

Targeting the 5'-AMP-activated protein kinase and related metabolic pathways for the treatment of prostate cancer by Popovics, Petra, Frigo, Daniel E, Schally, Andrew V, Rick, Ferenc G

“…Increasing evidence suggests that prostate cancer cells undergo unique metabolic reprogramming during transformation. A master regulator of cellular…”
Get more information

Role of growth hormone-releasing hormone in dyslipidemia associated with experimental type 1 diabetes by Romero, Maritza J., Lucas, Rudolf, Dou, Huijuan, Sridhar, Supriya, Czikora, Istvan, Mosieri, Eby M., Rick, Ferenc G., Block, Norman L., Sridhar, Subbaramiah, Fulton, David, Weintraub, Neal L., Bagi, Zsolt, Schally, Andrew V.

“…Dyslipidemia associated with triglyceride-rich lipoproteins (TRLs) represents an important residual risk factor for cardiovascular and chronic kidney disease…”
Get full text

Potentiating effects of GHRH analogs on the response to chemotherapy by Schally, Andrew V, Perez, Roberto, Block, Norman L, Rick, Ferenc G

“…Growth hormone releasing hormone (GHRH) from hypothalamus nominatively stimulates growth hormone release from adenohypophysis. GHRH is also produced by…”
Get full text

A new approach to the treatment of acute myeloid leukaemia targeting the receptor for growth hormone‐releasing hormone by Jimenez, Joaquin J., DelCanto, Gina M., Popovics, Petra, Perez, Aymee, Vila Granda, Ailin, Vidaurre, Irving, Cai, Ren‐Zhi, Rick, Ferenc G., Swords, Ronan T., Schally, Andrew V.

“…Summary Growth hormone‐releasing hormone (GHRH) is secreted by the hypothalamus and acts on the pituitary gland to stimulate the release of growth hormone…”
Get full text

Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema by Lucas, Rudolf, Sridhar, Supriya, Rick, Ferenc G, Gorshkov, Boris, Umapathy, Nagavedi S, Yang, Guang, Oseghale, Aluya, Verin, Alexander D, Chakraborty, Trinad, Matthay, Michael A, Zemskov, Evgeny A, White, Richard, Block, Norman L, Schally, Andrew V

“…Aggressive treatment with antibiotics in patients infected with Streptococcus pneumoniae induces release of the bacterial virulence factor pneumolysin (PLY)…”
Get full text

Activation of growth hormone releasing hormone (GHRH) receptor stimulates cardiac reverse remodeling after myocardial infarction (MI) by Kanashiro-Takeuchi, Rosemeire M., Takeuchi, Lauro M., Rick, Ferenc G., Dulce, Raul, Treuer, Adriana V., Florea, Victoria, Rodrigues, Claudia O., Paulino, Ellena C., Hatzistergos, Konstantinos E., Selem, Sarah M., Gonzalez, Daniel R., Block, Norman L., Schally, Andrew V., Hare, Joshua M.

“…Both cardiac myocytes and cardiac stem cells (CSCs) express the receptor of growth hormone releasing hormone (GHRH), activation of which improves injury…”
Get full text

Synthesis of new potent agonistic analogs of growth hormone-releasing hormone (GHRH) and evaluation of their endocrine and cardiac activities by Cai, Renzhi, Schally, Andrew V., Cui, Tengjiao, Szalontay, Luca, Halmos, Gabor, Sha, Wei, Kovacs, Magdolna, Jaszberenyi, Miklos, He, Jinlin, Rick, Ferenc G., Popovics, Petra, Kanashiro-Takeuchi, Rosemeire, Hare, Joshua M., Block, Norman L., Zarandi, Marta

“…•Analogs of GHRH modified at the N- and/or C-terminus were designed and synthesized.•Endocrine activities and binding affinities were determined.•Two analogs…”
Get full text

MP44-11 GROWTH HORMONE-RELEASING HORMONE (GHRH) ANTAGONISTS REDUCE INFLAMMATION- AND TRANSFORMING GROWTH FACTOR (TGF)-?2-INDUCED PROLIFERATION OF HUMAN BPH-1 PROSTATE EPITHELIAL CELLS GROWN IN 3D CULTURE by Popovics, Petra, Schally, Andrew V, Perez, Roberto, Cai, Rhenzi, Rick, Ferenc G

Get full text