Search Results - "Ferdinand, John R"

Mechanisms of Jak/STAT signaling in immunity and disease by Villarino, Alejandro V, Kanno, Yuka, Ferdinand, John R, O'Shea, John J

“…More than two decades ago, experiments on the antiviral mechanisms of IFNs led to the discovery of JAKs and their downstream effectors, the STAT proteins. This…”
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Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis by Jing, Chenzhi, Castro-Dopico, Tomas, Richoz, Nathan, Tuong, Zewen K., Ferdinand, John R., Lok, Laurence S. C., Loudon, Kevin W., Banham, Gemma D., Mathews, Rebeccah J., Cader, Zaeem, Fitzpatrick, Susan, Bashant, Kathleen R., Kaplan, Mariana J., Kaser, Arthur, Johnson, Randall S., Murphy, Michael P., Siegel, Richard M., Clatworthy, Menna R.

“…IgG antibodies cause inflammation and organ damage in autoimmune diseases such as systemic lupus erythematosus (SLE). We investigated the metabolic profile of…”
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GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation by Castro-Dopico, Tomas, Fleming, Aaron, Dennison, Thomas W., Ferdinand, John R., Harcourt, Katherine, Stewart, Benjamin J., Cader, Zaeem, Tuong, Zewen K., Jing, Chenzhi, Lok, Laurence S.C., Mathews, Rebeccah J., Portet, Anaïs, Kaser, Arthur, Clare, Simon, Clatworthy, Menna R.

“…Macrophages play a central role in intestinal immunity, but inappropriate macrophage activation is associated with inflammatory bowel disease (IBD). Here, we…”
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Regional Differences in Human Biliary Tissues and Corresponding In Vitro–Derived Organoids by Rimland, Casey A., Tilson, Samantha G., Morell, Carola M., Tomaz, Rute A., Lu, Wei‐Yu, Adams, Simone E., Georgakopoulos, Nikitas, Otaizo‐Carrasquero, Francisco, Myers, Timothy G., Ferdinand, John R., Gieseck, Richard L., Sampaziotis, Fotios, Tysoe, Olivia C., Ross, Alexander, Kraiczy, Judith M., Wesley, Brandon, Muraro, Daniele, Zilbauer, Matthias, Oniscu, Gabriel C., Hannan, Nicholas R.F., Forbes, Stuart J., Saeb‐Parsy, Kourosh, Wynn, Thomas A., Vallier, Ludovic

“…Background and Aims Organoids provide a powerful system to study epithelia in vitro. Recently, this approach was applied successfully to the biliary tree, a…”
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Tissue-resident B cells orchestrate macrophage polarisation and function by Suchanek, Ondrej, Ferdinand, John R., Tuong, Zewen K., Wijeyesinghe, Sathi, Chandra, Anita, Clauder, Ann-Katrin, Almeida, Larissa N., Clare, Simon, Harcourt, Katherine, Ward, Christopher J., Bashford-Rogers, Rachael, Lawley, Trevor, Manz, Rudolf A., Okkenhaug, Klaus, Masopust, David, Clatworthy, Menna R.

“…B cells play a central role in humoral immunity but also have antibody-independent functions. Studies to date have focused on B cells in blood and secondary…”
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Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift by Zhang, Yang, Garcia-Ibanez, Laura, Ulbricht, Carolin, Lok, Laurence S. C., Pike, Jeremy A., Mueller-Winkler, Jennifer, Dennison, Thomas W., Ferdinand, John R., Burnett, Cameron J. M., Yam-Puc, Juan C., Zhang, Lingling, Alfaro, Raul Maqueda, Takahama, Yousuke, Ohigashi, Izumi, Brown, Geoffrey, Kurosaki, Tomohiro, Tybulewicz, Victor L. J., Rot, Antal, Hauser, Anja E., Clatworthy, Menna R., Toellner, Kai-Michael

“…Infection or vaccination leads to the development of germinal centers (GC) where B cells evolve high affinity antigen receptors, eventually producing…”
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HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting by Neubert, Patrick, Weichselbaum, Andrea, Reitinger, Carmen, Schatz, Valentin, Schröder, Agnes, Ferdinand, John R., Simon, Michaela, Bär, Anna-Lorena, Brochhausen, Christoph, Gerlach, Roman G., Tomiuk, Stefan, Hammer, Karin, Wagner, Stefan, van Zandbergen, Ger, Binger, Katrina J., Müller, Dominik N., Kitada, Kento, Clatworthy, Menna R., Kurts, Christian, Titze, Jens, Abdullah, Zeinab, Jantsch, Jonathan

“…Infection and inflammation are able to induce diet-independent Na + -accumulation without commensurate water retention in afflicted tissues, which favors the…”
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Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo by Booty, Lee M, Gawel, Justyna M, Cvetko, Filip, Caldwell, Stuart T, Hall, Andrew R, Mulvey, John F, James, Andrew M, Hinchy, Elizabeth C, Prime, Tracy A, Arndt, Sabine, Beninca, Cristiane, Bright, Thomas P, Clatworthy, Menna R, Ferdinand, John R, Prag, Hiran A, Logan, Angela, Prudent, Julien, Krieg, Thomas, Hartley, Richard C, Murphy, Michael P

“…Mitochondrial glutathione (GSH) and thioredoxin (Trx) systems function independently of the rest of the cell. While maintenance of mitochondrial thiol redox…”
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Atypical B cells and impaired SARS-CoV-2 neutralization following heterologous vaccination in the elderly by Ferreira, Isabella A.T.M., Lee, Colin Y.C., Foster, William S., Abdullahi, Adam, Dratva, Lisa M., Tuong, Zewen Kelvin, Stewart, Benjamin J., Ferdinand, John R., Guillaume, Stephane M., Potts, Martin O.P., Perera, Marianne, Krishna, Benjamin A., Peñalver, Ana, Cabantous, Mia, Kemp, Steven A., Ceron-Gutierrez, Lourdes, Ebrahimi, Soraya, Lyons, Paul, Smith, Kenneth G.C., Bradley, John, Collier, Dami A., McCoy, Laura E., van der Klaauw, Agatha, Thaventhiran, James E.D., Farooqi, I. Sadaf, Teichmann, Sarah A., MacAry, Paul A., Doffinger, Rainer, Wills, Mark R., Linterman, Michelle A., Clatworthy, Menna R., Gupta, Ravindra K.

“…Suboptimal responses to a primary vaccination course have been reported in the elderly, but there is little information regarding the impact of age on…”
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Heat inactivation of clinical COVID-19 samples on an industrial scale for low risk and efficient high-throughput qRT-PCR diagnostic testing by Delpuech, Oona, Douthwaite, Julie A., Hill, Thomas, Niranjan, Dhevahi, Malintan, Nancy T., Duvoisin, Hannah, Elliott, Jane, Goodfellow, Ian, Hosmillo, Myra, Orton, Alexandra L., Taylor, Molly A., Brankin, Christopher, Pitt, Haidee, Ross-Thriepland, Douglas, Siek, Magdalena, Cuthbert, Anna, Richards, Ian, Ferdinand, John R., Barker, Colin, Shaw, Robert, Ariani, Cristina, Waddell, Ian, Rees, Steve, Green, Clive, Clark, Roger, Upadhyay, Abhishek, Howes, Rob

“…We report the development of a large scale process for heat inactivation of clinical COVID-19 samples prior to laboratory processing for detection of…”
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Bromodomain Inhibitors Modulate FcγR-Mediated Mononuclear Phagocyte Activation and Chemotaxis by Banham, Gemma D, Lee, Colin Y C, Ferdinand, John R, Matthews, Rebeccah J, Jing, Chenzhi, Smithers, Nicholas, Prinjha, Rab K, Clatworthy, Menna R

“…IgG antibodies form immune complexes (IC) that propagate inflammation and tissue damage in autoimmune diseases such as systemic lupus erythematosus. IgG IC…”
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Non-Invasive Multiphoton Imaging of Islets Transplanted Into the Pinna of the NOD Mouse Ear Reveals the Immediate Effect of Anti-CD3 Treatment in Autoimmune Diabetes by Benson, Robert A, Garcon, Fabien, Recino, Asha, Ferdinand, John R, Clatworthy, Menna R, Waldmann, Herman, Brewer, James M, Okkenhaug, Klaus, Cooke, Anne, Garside, Paul, Wållberg, Maja

“…We present a novel and readily accessible method facilitating cellular time-resolved imaging of transplanted pancreatic islets. Grafting of islets to the mouse…”
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Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence by Riding, Alexandra M., Loudon, Kevin W., Guo, Andrew, Ferdinand, John R., Lok, Laurence S.C., Richoz, Nathan, Stewart, Andrew, Castro-Dopico, Tomas, Tuong, Zewen Kelvin, Fiancette, Remi, Bowyer, Georgina S., Fleming, Aaron, Gillman, Eleanor S., Suchanek, Ondrej, Mahbubani, Krishnaa T., Saeb-Parsy, Kourosh, Withers, David, Dougan, Gordan, Clare, Simon, Clatworthy, Menna R.

“…Bladder infection affects a hundred million people annually, but our understanding of bladder immunity is incomplete. We found type 17 immune response genes…”
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A model of impaired Langerhans cell maturation associated with HPV induced epithelial hyperplasia by Tuong, Zewen K., Lukowski, Samuel W., Nguyen, Quan H., Chandra, Janin, Zhou, Chenhao, Gillinder, Kevin, Bashaw, Abate A., Ferdinand, John R., Stewart, Benjamin J., Teoh, Siok Min, Hanson, Sarah J., Devitt, Katharina, Clatworthy, Menna R., Powell, Joseph E., Frazer, Ian H.

“…Langerhans cells (LC) are skin-resident antigen-presenting cells that regulate immune responses to epithelial microorganisms. Human papillomavirus (HPV)…”
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A cell atlas of human thymic development defines T cell repertoire formation by Park, Jong-Eun, Botting, Rachel A, Domínguez Conde, Cecilia, Popescu, Dorin-Mirel, Lavaert, Marieke, Kunz, Daniel J, Goh, Issac, Stephenson, Emily, Ragazzini, Roberta, Tuck, Elizabeth, Wilbrey-Clark, Anna, Roberts, Kenny, Kedlian, Veronika R, Ferdinand, John R, He, Xiaoling, Webb, Simone, Maunder, Daniel, Vandamme, Niels, Mahbubani, Krishnaa T, Polanski, Krzysztof, Mamanova, Lira, Bolt, Liam, Crossland, David, de Rita, Fabrizio, Fuller, Andrew, Filby, Andrew, Reynolds, Gary, Dixon, David, Saeb-Parsy, Kourosh, Lisgo, Steven, Henderson, Deborah, Vento-Tormo, Roser, Bayraktar, Omer A, Barker, Roger A, Meyer, Kerstin B, Saeys, Yvan, Bonfanti, Paola, Behjati, Sam, Clatworthy, Menna R, Taghon, Tom, Haniffa, Muzlifah, Teichmann, Sarah A

“…The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic…”
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Spatiotemporal immune zonation of the human kidney by Stewart, Benjamin J, Ferdinand, John R, Young, Matthew D, Mitchell, Thomas J, Loudon, Kevin W, Riding, Alexandra M, Richoz, Nathan, Frazer, Gordon L, Staniforth, Joy U L, Vieira Braga, Felipe A, Botting, Rachel A, Popescu, Dorin-Mirel, Vento-Tormo, Roser, Stephenson, Emily, Cagan, Alex, Farndon, Sarah J, Polanski, Krzysztof, Efremova, Mirjana, Green, Kile, Del Castillo Velasco-Herrera, Martin, Guzzo, Charlotte, Collord, Grace, Mamanova, Lira, Aho, Tevita, Armitage, James N, Riddick, Antony C P, Mushtaq, Imran, Farrell, Stephen, Rampling, Dyanne, Nicholson, James, Filby, Andrew, Burge, Johanna, Lisgo, Steven, Lindsay, Susan, Bajenoff, Marc, Warren, Anne Y, Stewart, Grant D, Sebire, Neil, Coleman, Nicholas, Haniffa, Muzlifah, Teichmann, Sarah A, Behjati, Sam, Clatworthy, Menna R

“…Tissue-resident immune cells are important for organ homeostasis and defense. The epithelium may contribute to these functions directly or by cross-talk with…”
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Using single-cell technologies to map the human immune system — implications for nephrology by Stewart, Benjamin J., Ferdinand, John R., Clatworthy, Menna R.

“…Advances in single-cell technologies are transforming our understanding of cellular identity. For instance, the application of single-cell RNA sequencing and…”
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Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis by Castro-Dopico, Tomas, Dennison, Thomas W., Ferdinand, John R., Mathews, Rebeccah J., Fleming, Aaron, Clift, Dean, Stewart, Benjamin J., Jing, Chenzhi, Strongili, Konstantina, Labzin, Larisa I., Monk, Edward J.M., Saeb-Parsy, Kourosh, Bryant, Clare E., Clare, Simon, Parkes, Miles, Clatworthy, Menna R.

“…Inflammatory bowel disease is a chronic, relapsing condition with two subtypes, Crohn’s disease (CD) and ulcerative colitis (UC). Genome-wide association…”
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Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response by Mulderrig, Lee, Garaycoechea, Juan I., Tuong, Zewen K., Millington, Christopher L., Dingler, Felix A., Ferdinand, John R., Gaul, Liam, Tadross, John A., Arends, Mark J., O’Rahilly, Stephen, Crossan, Gerry P., Clatworthy, Menna R., Patel, Ketan J.

“…Endogenous DNA damage can perturb transcription, triggering a multifaceted cellular response that repairs the damage, degrades RNA polymerase II and shuts down…”
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Distinct microbial and immune niches of the human colon by James, Kylie R., Gomes, Tomas, Elmentaite, Rasa, Kumar, Nitin, Gulliver, Emily L., King, Hamish W., Stares, Mark D., Bareham, Bethany R., Ferdinand, John R., Petrova, Velislava N., Polański, Krzysztof, Forster, Samuel C., Jarvis, Lorna B., Suchanek, Ondrej, Howlett, Sarah, James, Louisa K., Jones, Joanne L., Meyer, Kerstin B., Clatworthy, Menna R., Saeb-Parsy, Kourosh, Lawley, Trevor D., Teichmann, Sarah A.

“…Gastrointestinal microbiota and immune cells interact closely and display regional specificity; however, little is known about how these communities differ…”
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