Search Results - "Feracci, Mikael"

A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase by Shannon, Ashleigh, Fattorini, Véronique, Sama, Bhawna, Selisko, Barbara, Feracci, Mikael, Falcou, Camille, Gauffre, Pierre, El Kazzi, Priscila, Delpal, Adrien, Decroly, Etienne, Alvarez, Karine, Eydoux, Cécilia, Guillemot, Jean-Claude, Moussa, Adel, Good, Steven S., La Colla, Paolo, Lin, Kai, Sommadossi, Jean-Pierre, Zhu, Yingxiao, Yan, Xiaodong, Shi, Hui, Ferron, François, Canard, Bruno

“…The guanosine analog AT-527 represents a promising candidate against Severe Acute Respiratory Syndrome coronavirus type 2 (SARS-CoV-2). AT-527 recently entered…”
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The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution by Chazot, Aurélie, Zimberger, Claire, Feracci, Mikael, Moussa, Adel, Good, Steven, Sommadossi, Jean-Pierre, Alvarez, Karine, Ferron, François, Canard, Bruno

“…Bemnifosbuvir (AT-527) and AT-752 are guanosine analogues currently in clinical trials against several RNA viruses. Here, we show that these drugs require a…”
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Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68 by Feracci, Mikael, Foot, Jaelle N., Grellscheid, Sushma N., Danilenko, Marina, Stehle, Ralf, Gonchar, Oksana, Kang, Hyun-Seo, Dalgliesh, Caroline, Meyer, N. Helge, Liu, Yilei, Lahat, Albert, Sattler, Michael, Eperon, Ian C., Elliott, David J., Dominguez, Cyril

“…Sam68 and T-STAR are members of the STAR family of proteins that directly link signal transduction with post-transcriptional gene regulation. Sam68 controls…”
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Biophysical and structural study of La Crosse virus endonuclease inhibition for the development of new antiviral options by Feracci, Mikael, Hernandez, Sergio, Garlatti, Laura, Mondielli, Clemence, Vincentelli, Renaud, Canard, Bruno, Reguera, Juan, Ferron, François, Alvarez, Karine

“…The large Bunyavirales order includes several families of viruses with a segmented ambisense (-) RNA genome and a cytoplasmic life cycle that starts by…”
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MEMO associated with an ErbB2 receptor phosphopeptide reveals a new phosphotyrosine motif by Feracci, Mikaël, Pimentel, Cyril, Bornet, Olivier, Roche, Philippe, Salaun, Danièle, Badache, Ali, Guerlesquin, Françoise

“…► ErbB2 is associated with the most aggressive tumors. ► MEMO is a new class of phosphotyrosine binding protein that binds ErbB2. ► We present a structural…”
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The activation chain of the broad-spectrum antiviral bemnifosbuvir at atomic resolution by Chazot, Aurelie, Zimberger, Claire, Feracci, Mikael, Moussa, Adel, Good, Steven, Sommadossi, Jean-Pierre, Alvarez, Karine, Ferron, Francois, Canard, Bruno

“…Bemnifosbuvir (AT-527) and AT-752 are guanosine analogues currently in clinical trials against several RNA viruses. Here we show that these drugs require a…”
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An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complex by Shannon, Ashleigh, Chazot, Aurélie, Feracci, Mikael, Falcou, Camille, Fattorini, Véronique, Selisko, Barbara, Good, Steven, Moussa, Adel, Sommadossi, Jean-Pierre, Ferron, François, Alvarez, Karine, Canard, Bruno

“…Nucleotide analogues (NA) are currently employed for treatment of several viral diseases, including COVID-19. NA prodrugs are intracellularly activated to the…”
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Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein–Protein Interaction: A Semi-Automated “Hit Identification-to-Optimization” Approach by Hoffer, Laurent, Garcia, Manon, Leblanc, Raphael, Feracci, Mikael, Betzi, Stéphane, Ben Yaala, Khaoula, Daulat, Avais M., Zimmermann, Pascale, Roche, Philippe, Barral, Karine, Morelli, Xavier

“…The rapid identification of early hits by fragment-based approaches and subsequent hit-to-lead optimization represents a challenge for drug discovery. To…”
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Fragment-based drug design targeting syntenin PDZ2 domain involved in exosomal release and tumour spread by Garcia, Manon, Hoffer, Laurent, Leblanc, Raphaël, Benmansour, Fatiha, Feracci, Mikael, Derviaux, Carine, Egea-Jimenez, Antonio Luis, Roche, Philippe, Zimmermann, Pascale, Morelli, Xavier, Barral, Karine

“…Syntenin stimulates exosome production and its expression is upregulated in many cancers and implicated in the spread of metastatic tumor. These effects are…”
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Structural investigations of the RNA-binding properties of STAR proteins by Feracci, Mikael, Foot, Jaelle, Dominguez, Cyril

“…STAR (signal transduction and activation of RNA) proteins are a family of RNA-binding proteins that regulate post-transcriptional gene regulation events at…”
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Identification of potent inhibitors of arenavirus and SARS-CoV-2 exoribonucleases by fluorescence polarization assay by Hernández, Sergio, Feracci, Mikael, De Jesus, Carolina Trajano, El Kazzi, Priscila, Kaci, Rafik, Garlatti, Laura, Mondielli, Clemence, Bailly, Fabrice, Cotelle, Philippe, Touret, Franck, de Lamballerie, Xavier, Coutard, Bruno, Decroly, Etienne, Canard, Bruno, Ferron, François, Alvarez, Karine

“…Viral exoribonucleases are uncommon in the world of RNA viruses. To date, they have only been identified in the Arenaviridae and the Coronaviridae families…”
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In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor by Ariey‐Bonnet, Jeremy, Carrasco, Kendall, Le Grand, Marion, Hoffer, Laurent, Betzi, Stéphane, Feracci, Mikael, Tsvetkov, Philipp, Devred, Francois, Collette, Yves, Morelli, Xavier, Ballester, Pedro, Pasquier, Eddy

“…Drug polypharmacology was explored in silico to identify novel molecular targets of antihelminthic drug mebendazole, currently repurposed for the treatment of…”
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AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5 by Feracci, Mikael, Eydoux, Cécilia, Fattorini, Véronique, Lo Bello, Lea, Gauffre, Pierre, Selisko, Barbara, Sutto-Ortiz, Priscila, Shannon, Ashleigh, Xia, Hongjie, Shi, Pei-Yong, Noel, Mathieu, Debart, Françoise, Vasseur, Jean-Jacques, Good, Steve, Lin, Kai, Moussa, Adel, Sommadossi, Jean-Pierre, Chazot, Aurélie, Alvarez, Karine, Guillemot, Jean-Claude, Decroly, Etienne, Ferron, François, Canard, Bruno

“…AT-752 is a guanosine analogue prodrug active against dengue virus (DENV). In infected cells, it is metabolized into 2′-methyl-2′-fluoro guanosine…”
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Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation by Elantak, Latifa, Espeli, Marion, Boned, Annie, Bornet, Olivier, Bonzi, Jeremy, Gauthier, Laurent, Feracci, Mikael, Roche, Philippe, Guerlesquin, Françoise, Schiff, Claudine

“…During B cell differentiation in the bone marrow, the expression and activation of the pre-B cell receptor (pre-BCR) constitute crucial checkpoints for B cell…”
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Screening protein – Single stranded RNA complexes by NMR spectroscopy for structure determination by Foot, Jaelle N., Feracci, Mikael, Dominguez, Cyril

“…In the past few years, RNA molecules have been revealed to be at the center of numerous biological processes. Long considered as passive molecules transferring…”
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Binding site density enables paralog-specific activity of SLM2 and Sam68 proteins in Neurexin2 AS4 splicing control by Danilenko, Marina, Dalgliesh, Caroline, Pagliarini, Vittoria, Naro, Chiara, Ehrmann, Ingrid, Feracci, Mikael, Kheirollahi-Chadegani, Mahsa, Tyson-Capper, Alison, Clowry, Gavin J, Fort, Philippe, Dominguez, Cyril, Sette, Claudio, Elliott, David J

“…SLM2 and Sam68 are splicing regulator paralogs that usually overlap in function, yet only SLM2 and not Sam68 controls the Neurexin2 AS4 exon important for…”
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NMR and MD Investigations of Human Galectin-1/Oligosaccharide Complexes by Meynier, Christophe, Feracci, Mikael, Espeli, Marion, Chaspoul, Florence, Gallice, Philippe, Schiff, Claudine, Guerlesquin, Françoise, Roche, Philippe

“…The specific recognition of carbohydrates by lectins plays a major role in many cellular processes. Galectin-1 belongs to a family of 15 structurally related…”
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Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation by Elantak, Latifa, Espeli, Marion, Boned, Annie, Bornet, Olivier, Bonzi, Jeremy, Gauthier, Laurent, Feracci, Mikael, Roche, Philippe, Guerlesquin, Francoise, Schiff, Claudine

“…Background: Galectin-1 (GAL1) is a ligand for the pre-BCR which is involved in the proliferation and differentiation of normal pre-BII cells. Results:…”
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