Search Results - "Fenwick, Mark L."

Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life by Pike, Kurt G., Allen, Joanne V., Caulkett, Peter W.R., Clarke, David S., Donald, Craig S., Fenwick, Mark L., Johnson, Keith M., Johnstone, Craig, McKerrecher, Darren, Rayner, John W., Walker, Rolf P., Wilson, Ingrid

“…The continued discovery of a novel series of pyridine acid containing glucokinase activators is described. The composite parameter of unbound clearance was…”
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Design of a potent, soluble glucokinase activator with excellent in vivo efficacy by McKerrecher, Darren, Allen, Joanne V., Caulkett, Peter W.R., Donald, Craig S., Fenwick, Mark L., Grange, Emma, Johnson, Keith M., Johnstone, Craig, Jones, Clifford D., Pike, Kurt G., Rayner, John W., Walker, Rolf P.

“…The optimisation of a series of glucokinase activators is described, including attempts to uncouple the relationship between potency and plasma protein…”
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Discovery, synthesis and biological evaluation of novel glucokinase activators by McKerrecher, Darren, Allen, Joanne V., Bowker, Suzanne S., Boyd, Scott, Caulkett, Peter W.R., Currie, Gordon S., Davies, Christopher D., Fenwick, Mark L., Gaskin, Harold, Grange, Emma, Hargreaves, Rod B., Hayter, Barry R., James, Roger, Johnson, Keith M., Johnstone, Craig, Jones, Clifford D., Lackie, Sarah, Rayner, John W., Walker, Rolf P.

“…[Display omitted] The identification, synthesis and SAR of a novel series of glucokinase activators is described. The interplay between lipophilicity, potency…”
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