Search Results - "Fenwick, Ashley"

Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases by Vazquez, Michael L, Kaila, Neelu, Strohbach, Joseph W, Trzupek, John D, Brown, Matthew F, Flanagan, Mark E, Mitton-Fry, Mark J, Johnson, Timothy A, TenBrink, Ruth E, Arnold, Eric P, Basak, Arindrajit, Heasley, Steven E, Kwon, Soojin, Langille, Jonathan, Parikh, Mihir D, Griffin, Sarah H, Casavant, Jeffrey M, Duclos, Brian A, Fenwick, Ashley E, Harris, Thomas M, Han, Seungil, Caspers, Nicole, Dowty, Martin E, Yang, Xin, Banker, Mary Ellen, Hegen, Martin, Symanowicz, Peter T, Li, Li, Wang, Lu, Lin, Tsung H, Jussif, Jason, Clark, James D, Telliez, Jean-Baptiste, Robinson, Ralph P, Unwalla, Ray

“…Janus kinases (JAKs) are intracellular tyrosine kinases that mediate the signaling of numerous cytokines and growth factors involved in the regulation of…”
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Concise Enantioselective Synthesis of ent-Malbrancheamide B by Frebault, Frederic, Simpkins, Nigel S, Fenwick, Ashley

“…A concise enantioselective synthesis of the fungal metabolite ent-malbrancheamide B was accomplished through the union of a C-prenylated proline derivative and…”
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Swimming against the tide: a case study of an integrated social studies department by Fenwick, Ashley J.J., Minty, Sarah, Priestley, Mark

“…A recent trend in developed countries' school curricula has been the transition from disciplinary to generic forms of knowledge, resulting in an emphasis on…”
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The antimicrobial natural product chuangxinmycin and Some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase by Brown, Murray J., Carter, Paul S., Fenwick, Ashley E., Fosberry, Andrew P., Hamprecht, Dieter W., Hibbs, Martin J., Jarvest, Richard L., Mensah, Lucy, Milner, Peter H., O'Hanlon, Peter J., Pope, Andrew J., Richardson, Christine M., West, Andrew, Witty, David R.

“…The antimicrobial natural product chuangxinmycin has been found to be a potent and selective inhibitor of bacterial tryptophanyl tRNA synthetase (WRS). A…”
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SAR and biological evaluation of 3-azabicyclo[3.1.0]hexane derivatives as μ opioid ligands by Lunn, Graham, Roberts, Lee R., Content, Stephane, Critcher, Douglas J., Douglas, Sara, Fenwick, Ashley E., Gethin, David M., Goodwin, Graham, Greenway, David, Greenwood, Sean, Hall, Kim, Thomas, Martin, Thompson, Stephen, Williams, David, Wood, Gavin, Wylie, Andrew

“…3-Azabicyclo[3.1.0]hexane compounds were designed as novel achiral μ opioid receptor ligands for the treatment of pruritus in dogs. In this paper, we describe…”
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3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3) by Smith, David G., Buffet, Marianne, Fenwick, Ashley E., Haigh, David, Ife, Robert J., Saunders, Martin, Slingsby, Brian P., Stacey, Rachel, Ward, Robert W.

“…Potent 3-anilino-4-arylmaleimide glycogen synthase kinase-3 (GSK-3) inhibitors have been prepared using automated array methodology. A number of these are…”
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Place-responsive pedagogy: learning from teachers' experiences of excursions in nature by Mannion, Greg, Fenwick, Ashley, Lynch, Jonathan

“…The nature-based excursion has been a significant teaching strategy in environmental education for decades. This article draws upon empirical data from a…”
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The first three years: experiences of early career teachers by Fenwick, Ashley

“…This study considers two discourses of current relevance to national and international educators - early professional learning (EPL) and curriculum change…”
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A Formal Asymmetric Synthesis of (+)-Anatoxin-a Using an Enantioselective Deprotonation Strategy on an Eight-Membered Ring by Aggarwal, Varinder K., Humphries, Paul S., Fenwick, Ashley

“…In only seven steps a formal synthesis of enantiomerically enriched (+)‐anatoxin‐a has been achieved. This was accomplished by utilizing a highly…”
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Cyclic Ketone Inhibitors of the Cysteine Protease Cathepsin K by Marquis, Robert W, Ru, Yu, Zeng, Jin, Trout, Robert E. Lee, LoCastro, Stephen M, Gribble, Andrew D, Witherington, Jason, Fenwick, Ashley E, Garnier, Benedicte, Tomaszek, Thaddeus, Tew, David, Hemling, Mark E, Quinn, Chad J, Smith, Ward W, Zhao, Baoguang, McQueney, Michael S, Janson, Cheryl A, D'Alessio, Karla, Veber, Daniel F

“…Cathepsin K (EC 3.4.22.38), a cysteine protease of the papain superfamily, is predominantly expressed in osteoclasts and has been postulated as a target for…”
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Solid-phase synthesis of cyclic alkoxyketones, inhibitors of the cysteine protease cathepsin K by FENWICK, Ashley E, GARNIER, Bénédicte, GRIBBLE, Andrew D, IFE, Robert J, RAWLINGS, Anthony D, WITHERINGTON, Jason

“…Using solid-phase synthesis, a library of novel cyclic alkoxyketones has been constructed which show strong inhibitory activity against the cysteine protease,…”
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Diastereoselective synthesis, activity and chiral stability of cyclic alkoxyketone inhibitors of cathepsin K by FENWICK, Ashley E, GRIBBLE, Andrew D, IFE, Robert J, STEVENS, Nichola, WITHERINGTON, Jason

“…The diastereoselective synthesis of a novel class of cathepsin K inhibitors together with their cathepsin K affinity and stability towards aqueous buffer is…”
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The impact of disrupted and disjointed early professional development on beginning teachers by Fenwick, Ashley, Weir, Douglas

“…This longitudinal study is set in the national and international contexts of early professional development, teacher careers, and teacher retention. It…”
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Relaxant activity of 4-amido-3,4-dihydro-2H-1-benzopyran-3-ols and 4-amido-2H-1-benzopyrans on guinea pig isolated trachealis by Buckle, Derek R, Arch, Jonathon R. S, Fenwick, Ashley E, Houge-Frydrych, Catherine S. V, Pinto, Ivan L, Smith, David G, Taylor, Stephen G, Tedder, John M

“…A series of 4-amido-3,4-dihydro-2H-1-benzopyran-3-ols and 4-amido-2H-1-benzopyrans related to the potassium channel activator cromakalim have been prepared and…”
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Inhibition of Cyclic Nucleotide Phosphodiesterase by Derivatives of 1,3-Bis(cyclopropylmethyl)xanthine by Buckle, Derek R, Arch, Jonathan R. S, Connolly, Brendan J, Fenwick, Ashley E, Foster, Keith A, Murray, Kenneth J, Readshaw, Simon A, Smallridge, Mark, Smith, David G

“…Alkylation of the selective type IV phosphodiesterase inhibitor, 8-amino-1,3-bis(cyclopropylmethyl)-xanthine (1, BRL 61063), led exclusively to the N-7…”
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Inhibition of human cytomegalovirus protease by enedione derivatives of thieno[2,3-d]oxazinones through a novel dual acylation/alkylation mechanism by Pinto, Ivan L., Jarvest, Richard L., Clarke, Brian, Dabrowski, Christine E., Fenwick, Ashley, Gorczyca, Michele M, Jennings, L.John, Lavery, Patrick, Sternberg, Edmund J, Tew, David G., West, Andrew

“…Enedione derivatives of thieno[2,3-d]oxazinones are nanomolar inhibitors of CMV protease which act through a novel dual acylation of the catalytic serine and…”
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Chapter 29. New developments in animal healthcare by Fenwick, Ashley E.

“…This chapter presents the developments in animal healthcare. There has been a pronounced shift from the traditional focus on medication for food animals toward…”
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Eine formale asymmetrische Synthese von (+)‐Anatoxin‐a durch enantioselektive Deprotonierung eines Achtrings by Aggarwal, Varinder K., Humphries, Paul S., Fenwick, Ashley

“…In nur sieben Stufen gelang die formale Synthese von enantiomerenangereichertem (+)‐Anatoxin‐a. Dies wurde erreicht durch eine hoch enantioselektive…”
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Endothelin-Converting Enzyme: Substrate Specificity and Inhibition by Novel Analogs of Phosphoramidon by Keller, Paul M., Lee, Chao-Pin, Fenwick, Ashley E., Atkinson, Steven T., Elliott, John D., DeWolf, Jr, Walter E.

“…Endothelin converting enzyme was partially purified by detergent extraction and ion exchange chromatography from porcine aortic endothelial cells. This…”
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Eine formale asymmetrische Synthese von (+)-Anatoxin-a durch enantioselektive Deprotonierung eines Achtrings by Aggarwal, Varinder K., Humphries, Paul S., Fenwick, Ashley

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