Search Results - "Fenton, W. W."

Allostery: an illustrated definition for the ‘second secret of life’ by Fenton, Aron W.

“…Although allosteric regulation is the ‘second secret of life’, the molecular mechanisms that give rise to allostery currently elude understanding. In my…”
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A critical review of the role of M2PYK in the Warburg effect by Harris, Robert A., Fenton, Aron W.

“…It is becoming generally accepted in recent literature that the Warburg effect in cancer depends on inhibition of M2PYK, the pyruvate kinase isozyme most…”
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Divalent cations in human liver pyruvate kinase exemplify the combined effects of complex-equilibrium and allosteric regulation by Martin, Tyler A., Fenton, Aron W.

“…There is growing recognition that the functional outcome of binding of an allosteric regulator to a protein/enzyme is influenced by the presence of other…”
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What Mutagenesis Can and Cannot Reveal About Allostery by Carlson, Gerald M., Fenton, Aron W.

“…Allosteric regulation of protein function is recognized to be widespread throughout biology; however, knowledge of allosteric mechanisms, the molecular changes…”
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Structural Plasticity Is a Feature of Rheostat Positions in the Human Na + /Taurocholate Cotransporting Polypeptide (NTCP) by Ruggiero, Melissa J, Malhotra, Shipra, Fenton, Aron W, Swint-Kruse, Liskin, Karanicolas, John, Hagenbuch, Bruno

“…In the Na /taurocholate cotransporting polypeptide (NTCP), the clinically relevant S267F polymorphism occurs at a "rheostat position". That is, amino acid…”
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Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophrenia by Fenton, Wayne S, Hibbeln, Joseph, Knable, Michael

“…Recent research suggests that deficient uptake or excessive breakdown of membrane phospholipids may be associated with schizophrenia. We review available…”
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Inhibition of Pyruvate Kinase From Thermoanaerobacterium saccharolyticum by IMP Is Independent of the Extra-C Domain by Fenton, Christopher A, Tang, Qingling, Olson, Daniel G, Maloney, Marybeth I, Bose, Jeffrey L, Lynd, Lee R, Fenton, Aron W

“…The pyruvate kinase (PYK) isozyme from (TsPYK) has previously been used in metabolic engineering for improved ethanol production. This isozyme belongs to a…”
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What Mutagenesis Can and Cannot Reveal About Allostery by Carlson, Gerald M., Fenton, Aron W.

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The pH dependence of the allosteric response of human liver pyruvate kinase to fructose-1,6-bisphosphate, ATP, and alanine by Fenton, Aron W., Hutchinson, Myra

“…The allosteric regulation of human liver pyruvate kinase (hL-PYK) by fructose-1,6-bisphosphate (Fru-1,6-BP; activator), ATP (inhibitor) and alanine (Ala;…”
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A Placebo-Controlled Trial of Omega-3 Fatty Acid (Ethyl Eicosapentaenoic Acid) Supplementation for Residual Symptoms and Cognitive Impairment in Schizophrenia by Fenton, Wayne S., Dickerson, Faith, Boronow, John, Hibbeln, Joseph R., Knable, Michael

“…OBJECTIVE: This study determined if augmentation of neuroleptics with 3 g day of ethyl eicosapentaenoic acid (EPA) improves symptoms and cognition in patients…”
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Determinants of medication compliance in schizophrenia: empirical and clinical findings by Fenton, W S, Blyler, C R, Heinssen, R K

“…Advances in psychopharmacology have produced medications with substantial efficacy in the treatment of positive and negative symptoms of schizophrenia and the…”
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A Radiographic Assessment of Pediatric Fracture Healing and Time Since Injury by Malone, Christina A., Sauer, Norman J., Fenton, Todd W.

“…:  Past studies and pediatric bone physiology indicate that younger individuals may heal at a faster rate. Additionally, in adults upper limb fractures heal…”
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Identification of Regions of Rabbit Muscle Pyruvate Kinase Important for Allosteric Regulation by Phenylalanine, Detected by H/D Exchange Mass Spectrometry by Prasannan, Charulata B, Villar, Maria T, Artigues, Antonio, Fenton, Aron W

“…Mass spectrometry has been used to determine the number of exchangeable backbone amide protons and the associated rate constants that are altered when rabbit…”
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The NIMH-MATRICS consensus statement on negative symptoms by Kirkpatrick, Brian, Fenton, Wayne S, Carpenter, Jr, William T, Marder, Stephen R

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How Should DSM-V Criteria for Schizophrenia Include Cognitive Impairment? by Keefe, Richard S. E., Fenton, Wayne S.

“…Neurocognitive impairment is considered a core component of schizophrenia and is increasingly under investigation as a potential treatment target. On average,…”
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Rheostats, toggles, and neutrals, Oh my! A new framework for understanding how amino acid changes modulate protein function by Swint-Kruse, Liskin, Fenton, Aron W.

“…Advances in personalized medicine and protein engineering require accurately predicting outcomes of amino acid substitutions. Many algorithms correctly predict…”
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Whole‐protein alanine‐scanning mutagenesis of allostery: A large percentage of a protein can contribute to mechanism by Tang, Qingling, Fenton, Aron W.

“…Many studies of allosteric mechanisms use limited numbers of mutations to test whether residues play “key” roles. However, if a large percentage of the protein…”
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Depression, Suicide, and Suicide Prevention in Schizophrenia by Fenton, Wayne S.

“…Suicide is the single largest cause of premature death among individuals with schizophrenia. Furthermore, epidemiological data indicate that nearly 80% of…”
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GroEL‐Mediated protein folding by Fenton, Wayne A., Horwich, Arthur L.

“…I Architecture of GroEL and GroES and the reaction pathway A. Architecture of the chaperonins B. Reaction pathway of GroEL‐GroES‐mediated folding II…”
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Residues in chaperonin GroEL required for polypeptide binding and release by Fenton, Wayne A, Kashi, Yechezkel, Furtak, Krystyna, Norwich, Arthur L

“…Chaperonins are ring-shaped protein complexes that are essential in the cell, mediating ATP-dependent polypeptide folding in a variety of compartments. Recent…”
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