Search Results - "Fenton, Robert G."

Myeloid cell factor–1 is a critical survival factor for multiple myeloma by Zhang, Bin, Gojo, Ivana, Fenton, Robert G.

“…Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells in the bone marrow caused primarily by failure of normal homeostatic…”
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Neurotoxicity of bortezomib therapy in multiple myeloma: A single‐center experience and review of the literature by Badros, Ashraf, Goloubeva, Olga, Dalal, Jay S., Can, Ilyas, Thompson, Jennifer, Rapoport, Aaron P., Heyman, Meyer, Akpek, Gorgon, Fenton, Robert G.

“…BACKGROUND. Bortezomib is active in heavily pretreated multiple myeloma patients; the dose‐limiting toxicity is peripheral neuropathy (PN). METHODS. The…”
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The Cyclin-dependent Kinase Inhibitor Flavopiridol Induces Apoptosis in Multiple Myeloma Cells through Transcriptional Repression and Down-Regulation of Mcl-1 by GOJO, Ivana, BIN ZHANG, FENTON, Robert G

“…Multiple myeloma (MM) is a B-cell malignancy characterized by the accumulation of malignant plasma cells with slow proliferative rate but enhanced survival. MM…”
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Bcl-2 family proteins regulate mitochondrial reactive oxygen production and protect against oxidative stress by Kowaltowski, Alicia J., Fenton, Robert G., Fiskum, Gary

“…Bcl-2 family proteins protect against a variety of forms of cell death, including acute oxidative stress. Previous studies have shown that overexpression of…”
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Phase II Study of G3139, a Bcl-2 Antisense Oligonucleotide, in Combination With Dexamethasone and Thalidomide in Relapsed Multiple Myeloma Patients by BADROS, Ashraf Z, GOLOUBEVA, Olga, GOCKE, Christopher D, TOMIC, Dragana, FLAWS, Jodi A, BIN ZHANG, FENTON, Robert G, RAPOPORT, Aaron P, RATTERREE, Bashi, GAHRES, Natalie, MEISENBERG, Barry, TAKEBE, Naoko, HEYMAN, Meyer, ZWIEBEL, James, STREICHER, Howard

“…Bcl-2 regulates the mitochondrial apoptosis pathway that promotes chemotherapy resistance. Bcl-2 antisense oligonucleotide, G3139, targets Bcl-2 mRNA. G3139…”
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Phase I Clinical Trial of the Inosine Monophosphate Dehydrogenase Inhibitor Mycophenolate Mofetil (Cellcept) in Advanced Multiple Myeloma Patients by TAKEBE, Naoko, XIANGFEI CHENG, ROSS, Douglas, MEISENBERG, Barry, TRICOT, Guido, SUHLAN WU, BAUER, Kenneth, GOLOUBEVA, Olga G, FENTON, Robert G, HEYMAN, Meyer, RAPOPORT, Aaron P, BADROS, Ashraf, SHAUGHNESSY, John

“…Purpose: Inosine monophosphate dehydrogenase (IMPDH) inhibitors have been used to induce leukemia blast cell differentiation but have not been tested in…”
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Computer Simulation of Bubble-Growth Phenomena in Foaming by Leung, Siu N, Park, Chul B, Xu, Donglai, Li, Hongbo, Fenton, Robert G

“…This paper discusses the research conducted to achieve an accurate bubble-growth model and simulation scheme to describe precisely the bubble-growth phenomena…”
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Pipeline-Architecture Based Real-Time Active-Vision for Human-Action Recognition by Mackay, Matthew, Fenton, Robert G., Benhabib, Beno

“…This paper presents a generic framework for on-line reconfiguration of a multi-camera active-vision system for time-varying-geometry object/subject action…”
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Multi-camera active surveillance of an articulated human form – An implementation strategy by Mackay, Matthew D., Fenton, Robert G., Benhabib, Beno

“…► Multi-camera active-vision system used to improve human action sensing performance. ► Environment may be cluttered with multiple, dynamic obstacles. ►…”
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Proliferation of IL-6-independent multiple myeloma does not require the activity of extracellular signal-regulated kinases (ERK1/2) by Zhang, Bin, Fenton, Robert G.

“…The evolutionarily conserved Ras/Raf/MEK/ERK pathway is thought to be essential for proliferation of eukaryotic cells. The human multiple myeloma (MM) cell…”
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Advances in biology and therapy of multiple myeloma by Barillé-Nion, Sophie, Barlogie, Bart, Bataille, Régis, Bergsagel, P Leif, Epstein, Joshua, Fenton, Robert G, Jacobson, Joth, Kuehl, W Michael, Shaughnessy, John, Tricot, Guido

“…Even during this past year, further advances have been made in understanding the molecular genetics of the disease, the mechanisms involved in the generation…”
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IL-6-independent expression of Mcl-1 in human multiple myeloma by BIN ZHANG, POTYAGAYLO, Valeria, FENTON, Robert G

“…Mcl-1 is a critical antiapoptotic survival factor for human multiple myeloma (MM). We examined the importance of IL-6 for Mcl-1 expression in five MM cell…”
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Flavopiridol in patients with relapsed or refractory multiple myeloma: a phase 2 trial with clinical and pharmacodynamic end-points by Dispenzieri, A, Gertz, MA, Lacy, MQ, Geyer, SM, Fitch, TR, Fenton, RG, Fonseca, R, Isham, CR, Ziesmer, SC, Erlichman, C, Bible, KC

“…Mayo Clinic Rochester, MN 55905, USA. angela@mayo.edu Flavopiridol downregulates anti-apoptotic regulators including Mcl-1, upregulates p53, globally…”
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Farnesyltransferase inhibitors reverse ras-mediated inhibition of Fas gene expression by BIN ZHANG, PRENDERGAST, George C, FENTON, Robert G

“…Factors that govern host-tumor interaction play a critical role in tumor progression. In previous studies we have shown that oncogenic Ras inhibits the…”
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Robotic interception of moving objects using an augmented ideal proportional navigation guidance technique by Mehrandezh, M., Sela, N.M., Fenton, R.G., Benhabib, B.

“…Presents an approach to online, robot-motion planning for moving-object interception. The proposed approach utilizes a navigation-guidance-based technique,…”
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Effect of the Convergent-Filamentary Die Geometry on Volume Expansion of PS Foams Blown With CO2 by DONGLAI XU, PARK, Chul B, FENTON, Robert G

“…This paper presents the effects of the convergent-filamentary die geometry on the volume expansion behaviors of extruded PS foams blown with supercritical CO2…”
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Irreversible G2-M arrest and cytoskeletal reorganization induced by cytotoxic nucleoside analogues by HALLORAN, P. J, FENTON, R. G

“…The mechanisms by which cytotoxic agents perturb the normal cell biology and cell cycle progression of cancer cells were explored using B16F10 cells…”
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Molecular Mechanisms of Immune-Mediated Lysis of Murine Renal Cancer: Differential Contributions of Perforin-Dependent Versus Fas-Mediated Pathways in Lysis by NK and T Cells by Sayers, Thomas J, Brooks, Alan D, Lee, Jong-Keuk, Fenton, Robert G, Komschlies, Kristin L, Wigginton, Jon M, Winkler-Pickett, Robin, Wiltrout, Robert H

“…Mice bearing the experimental murine renal cancer Renca can be successfully treated with some forms of immunotherapy. In the present study, we have…”
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On-Line Robotic Interception Planning Using a Rendezvous-Guidance Technique by Agah, Farhad, Mehrandezh, Mehran, Fenton, Robert G, Benhabib, Beno

“…A novel method for online, robotic interception of moving objects using visual feedback is proposed in this paper. No prior knowledge of the motion of the…”
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Inhibition of Fas (CD95) expression and Fas-mediated apoptosis by oncogenic Ras by FENTON, R. G, HIXON, J. A, WRIGHT, P. W, BROOKS, A. D, SAYERS, T. J

“…The ras oncogene plays an important role in the multistep progression to cancer by activation of signal transduction pathways that contribute to aberrant…”
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