Search Results - "Fenster, Michaël D.B."

Total Synthesis of Spirastrellolide F Methyl Ester--Part 2: Macrocyclization and Completion of the Synthesis by Benson, Stefan, Collin, Marie-Pierre, O'Neil, Gregory W, Ceccon, Julien, Fasching, Bernhard, Fenster, Michaël D.B, Godbout, Cédrickx, Radkowski, Karin, Goddard, Richard, Fürstner, Alois

“…Marvel of the sea: A concise and highly convergent total synthesis of the methyl ester of the marine macrolide spirastrellolide F (see picture), which has…”
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An azirine solid-state photodegradant of the CCR2/CCR5 dual antagonist BMS-813160 by Ayers, Sloan, La Cruz, Thomas, Park, Hyunsoo, Ramirez, Antonio, Hritzko, Benjamin, Sarjeant, Amy, Lin, Ziqing, Zaretsky, Serge, Huang, Yande, Zang, Jia, Yuill, Elizabeth M., Fenster, Michaël D.B.

“…[Display omitted] The synthesis of the CCR2/5 dual chemokine antagonist BMS-813160 (1) presented a number of interesting impurity and degradant structure…”
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Palladium-Catalyzed C–O Coupling of a Sterically Hindered Secondary Alcohol with an Aryl Bromide and Significant Purity Upgrade in the API Step by Young, Ian S, Simmons, Eric M, Fenster, Michaël D. B, Zhu, Jason J, Katipally, Kishta R

“…The final two steps used to prepare greater than 1 kg of a compound evaluated as a treatment for type 2 diabetes are reported. The application of a…”
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Enzymatic reduction of α-substituted ketones with concomitant dynamic kinetic resolution by Hanson, Ronald L., Guo, Zhiwei, González-Bobes, Francisco, Fenster, Michaël D.B., Goswami, Animesh

“…[Display omitted] •Enzymatic reduction of racemic α-substituted ketones and simultaneous dynamic kinetic resolution.•Stereoselective preparation of homochiral…”
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Total Syntheses of the Actin-Binding Macrolides Latrunculin A, B, C, M, S and 16-epi-Latrunculin B by Fürstner, Alois, De Souza, Dominic, Turet, Laurent, Fenster, Michaël D. B., Parra-Rapado, Liliana, Wirtz, Conny, Mynott, Richard, Lehmann, Christian W.

“…The latrunculins are highly selective actin‐binding marine natural products and as such play an important role as probe molecules for chemical biology. A…”
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Development of a Control Strategy for a Final Intermediate to Enable Impurities Control by Ramirez, Antonio, Hallow, Daniel M, Fenster, Michaël D. B, Lou, Sha, Domagalski, Nathan R, Tummala, Srinivas, Srivastava, Sushil, Hobson, Lindsay A

“…This manuscript describes the development of a control strategy for impurities in the final intermediate step of the asunaprevir drug substance utilizing the…”
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Rhodium-Catalyzed Cyclopropanation of Alkenes with Dimethyl Diazomalonate by González-Bobes, Francisco, Fenster, Michaël D. B., Kiau, Susanne, Kolla, Laxma, Kolotuchin, Sergei, Soumeillant, Maxime

“…The outstanding ability of dirhodium α,α,α′,α′‐tetramethyl‐1,3‐benzenedipropanoate [Rh2(esp)2; esp=α,α,α′,α′‐tetramethyl‐1,3‐benzenedipropanoate] to catalyze…”
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Toward the Total Synthesis of Spirastrellolide A. Part 2: Conquest of the Northern Hemisphere by Fürstner, Alois, Fenster, Michaël D. B., Fasching, Bernhard, Godbout, Cédrickx, Radkowski, Karin

“…North and South: The unique biological activity of the natural product spirastrellolide A renders it an attractive lead for anticancer agents. The southern…”
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Latrunculin Analogues with Improved Biological Profiles by "Diverted Total Synthesis": Preparation, Evaluation, and Computational Analysis by Fürstner, Alois, Kirk, Douglas, Fenster, Michaël D. B., Aïssa, Christophe, De Souza, Dominic, Nevado, Cristina, Tuttle, Tell, Thiel, Walter, Müller, Oliver

“…Deliberate digression from the blueprint of the total syntheses of latrunculin A (1) and latrunculin B (2) reported in the accompanying paper allowed for the…”
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Toward the Total Synthesis of Spirastrellolide A. Part 1: Strategic Considerations and Preparation of the Southern Domain by Fürstner, Alois, Fenster, Michaël D. B., Fasching, Bernhard, Godbout, Cédrickx, Radkowski, Karin

“…North and South: The unique biological activity of the natural product spirastrellolide A renders it an attractive lead for anticancer agents. The southern…”
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Toward the total synthesis of spirastrellolide A. Part 3: intelligence gathering and preparation of a ring-expanded analogue by Fürstner, Alois, Fasching, Bernhard, O'Neil, Gregory W, Fenster, Michaël D B, Godbout, Cédrickx, Ceccon, Julien

“…Different methods for the formation of the C.25-C.26 bond of spirastrellolide A () are evaluated that might qualify for the end game of the projected total…”
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A Formal Construction of Fasicularin by Fenster, Michaël D. B, Dake, Gregory R

“…Our synthetic approach toward fasicularin is presented. Key steps in this construction are a siloxy-epoxide semipinacol rearrangement, a B-alkyl Suzuki…”
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An Asymmetric Formal Synthesis of Fasicularin by Fenster, Michaël D. B., Dake, Gregory R.

“…An asymmetric formal synthesis of fasicularin (1) is described. This natural product, isolated from the extracts of the marine invertebrate Nephteis…”
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Synthesis of Functionalized 1-Azaspirocyclic Cyclopentanones Using Bronsted Acid or N-Bromosuccinimide Promoted Ring Expansions by Dake, Gregory R, Fenster, Michaël D. B, Hurley, Paul B, Patrick, Brian O

“…Azaspirocyclic ring systems are present in a variety of alkaloids. Functionalized 1-azaspirocyclopentanones (6, 7, 11, 12) can be efficiently constructed…”
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Investigations of α-Siloxy−Epoxide Ring Expansions Forming 1-Azaspirocyclic Ketones by Dake, Gregory R, Fenster, Michaël D. B, Fleury, Mélissa, Patrick, Brian O

“…The construction of 1-azaspirocyclic cycloalkanones using a siloxy−epoxide semipinacol ring expansion process was examined. Functionalized…”
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Construction of Azaspirocyclic Ketones through α-Hydroxyiminium Ion or α-Siloxy Epoxide Semipinacol Rearrangements by Fenster, Michaël D. B, Patrick, Brian O, Dake, Gregory R

“…Semipinacol-type rearrangements to produce azaspirocyclic ketones are presented. The yields and stereoselectivities of these reactions range from 67−94% yield…”
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Diverted Total Synthesis: Preparation of a Focused Library of Latrunculin Analogues and Evaluation of Their Actin-Binding Properties by Fürstner, Alois, Kirk, Douglas, Michaël D. B. Fenster, Aïssa, Christophe, De Souza, Dominic, Müller, Oliver, Nicolaou, Kyriacos C.

“…Two largely catalysis-based and highly convergent total syntheses of latrunculin A (1) and B (2) were diverted to the preparation of a focused library of…”
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