Search Results - "Fenner, Brittany"

Biomarker Evidence of the Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) in Chronic Critical Illness (CCI) After Surgical Sepsis by Darden, Dijoia B., Brakenridge, Scott C., Efron, Philip A., Ghita, Gabriela L., Fenner, Brittany P., Kelly, Lauren S., Mohr, Alicia M., Moldawer, Lyle L., Moore, Frederick A.

“…Objective: To analyze serial biomarkers of the persistent inflammation, immunosuppression, and catabolism syndrome (PICS) to gain insight into the pathobiology…”
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Dysregulated Immunity and Immunotherapy after Sepsis by Darden, Dijoia B, Kelly, Lauren S, Fenner, Brittany P, Moldawer, Lyle L, Mohr, Alicia M, Efron, Philip A

“…Implementation of protocolized surveillance, diagnosis, and management of septic patients, and of surgical sepsis patients in particular, is shown to result in…”
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The Hematopoietic Stem/Progenitor Cell Response to Hemorrhage, Injury, and Sepsis: A Review of Pathophysiology by Kelly, Lauren S., Darden, Dijoia B., Fenner, Brittany P., Efron, Philip A., Mohr, Alicia M.

“…ABSTRACTHematopoietic stem/progenitor cells (HSPC) have both unique and common responses following hemorrhage, injury, and sepsis. HSPCs from different…”
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Chronic “sepsis brain” and regulatory T cells – A promising therapeutic target by Darden, Dijoia B., Fenner, Brittany P., Foster, Thomas, Larson, Shawn, Efron, Philip A.

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Transcriptomic Changes Within Human Bone Marrow After Severe Trauma by Kelly, Lauren S., Apple, Camille G., Darden, Dijoia B., Kannan, Kolenkode B., Pons, Erick E., Fenner, Brittany P., Parvataneni, Hari K., Hagen, Jennifer E., Brakenridge, Scott C., Efron, Philip A., Mohr, Alicia M.

“…Severe trauma is associated with severe systemic inflammation and neuroendocrine activation that is associated with erythroid progenitor growth suppression and…”
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Immunological Endotyping of Chronic Critical Illness After Severe Sepsis by Fenner, Brittany P, Darden, D B, Kelly, Lauren S, Rincon, Jaimar, Brakenridge, Scott C, Larson, Shawn D, Moore, Frederick A, Efron, Philip A, Moldawer, Lyle L

“…Improved management of severe sepsis has been one of the major health care accomplishments of the last two decades. Due to enhanced recognition and improved…”
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Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications by Yonker, Lael M, Badaki-Makun, Oluwakemi, Arya, Puneeta, Boribong, Brittany P, Moraru, Gabriela, Fenner, Brittany, Rincon, Jaimar, Hopke, Alex, Rogers, Brent, Hinson, Jeremiah, Fasano, Alessio, Lee, Lilly, Kehoe, Sarah M, Larson, Shawn D, Chavez, Hector, Levin, Scott, Moldawer, Lyle L, Irimia, Daniel

“…Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening complication that can develop weeks to months after an initial SARS-CoV-2…”
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A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis by Darden, Dijoia B, Dong, Xiaoru, Brusko, Maigan A, Kelly, Lauren, Fenner, Brittany, Rincon, Jaimar C, Dirain, Marvin L, Ungaro, Ricardo, Nacionales, Dina C, Gauthier, Marie, Kladde, Michael, Brusko, Todd M, Bihorac, Azra, Moore, Frederick A, Loftus, Tyler, Bacher, Rhonda, Moldawer, Lyle L, Mohr, Alicia M, Efron, Philip A

“…With the successful implementation of the Surviving Sepsis Campaign guidelines, post-sepsis in-hospital mortality to sepsis continues to decrease. Those who…”
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Identification of unique microRNA expression patterns in bone marrow hematopoietic stem and progenitor cells after hemorrhagic shock and multiple injuries in young and old adult mice by Darden, Dijoia B., Mira, Juan C., Lopez, Maria-Cecilia, Stortz, Julie A., Fenner, Brittany P., Kelly, Lauren S., Nacionales, Dina C., Budharaju, Ashrita, Loftus, Tyler J., Baker, Henry V., Moore, Frederick A., Brakenridge, Scott C., Moldawer, Lyle L., Mohr, Alicia M., Efron, Philip A.

“…BACKGROUND After severe trauma, the older host experiences more dysfunctional hematopoiesis of bone marrow (BM) hematopoietic stem and progenitor cells…”
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Correction to: Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications by Yonker, Lael M, Badaki-Makun, Oluwakemi, Arya, Puneeta, Boribong, Brittany P, Moraru, Gabriela, Fenner, Brittany, Rincon, Jaimar, Hopke, Alex, Rogers, Brent, Hinson, Jeremiah, Fasano, Alessio, Lee, Lilly, Kehoe, Sarah M, Larson, Shawn D, Chavez, Hector, Levin, Scott, Moldawer, Lyle L, Irimia, Daniel

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A Transcriptomic Severity Metric That Predicts Clinical Outcomes in Critically Ill Surgical Sepsis Patients by Brakenridge, Scott C., Starostik, Petr, Ghita, Gabriella, Midic, Uros, Darden, Dijoia, Fenner, Brittany, Wacker, James, Efron, Philip A., Liesenfeld, Oliver, Sweeney, Timothy E., Moldawer, Lyle L.

“…OBJECTIVES: Clinically deployable methods for the rapid and accurate prediction of sepsis severity that could elicit a meaningful change in clinical practice…”
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Chronic Critical Illness Elicits a Unique Circulating Leukocyte Transcriptome in Sepsis Survivors by Darden, Dijoia B, Ghita, Gabriela L, Wang, Zhongkai, Stortz, Julie A, Lopez, Maria-Cecilia, Cox, Michael C, Hawkins, Russell B, Rincon, Jaimar C, Kelly, Lauren S, Fenner, Brittany P, Ozrazgat-Baslanti, Tezcan, Leeuwenburgh, Christiaan, Bihorac, Azra, Loftus, Tyler J, Moore, Frederick A, Brakenridge, Scott C, Baker, Henry V, Bacher, Rhonda, Mohr, Alicia M, Moldawer, Lyle L, Efron, Philip A

“…Surgical sepsis has evolved into two major subpopulations: patients who rapidly recover, and those who develop chronic critical illness (CCI). Our primary aim…”
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Sex differences associate with late microbiome alterations after murine surgical sepsis by Efron, Philip Alexander, Darden, Dijoia B., Li, Eric C., Munley, Jennifer, Kelly, Lauren, Fenner, Brittany, Nacionales, Dina C., Ungaro, Ricardo F., Dirain, Marvin L., Rincon, Jaimar, Mankowski, Robert T., Leeuwenburgh, Christiaan, Moore, Fredrick A., Brakenridge, Scott C., Foster, Thomas C., Laitano, Orlando, Casadesus, Gemma, Moldawer, Lyle L., Mohr, Alicia M., Thomas, Ryan M.

“…Sepsis-induced gut microbiome alterations contribute to sepsis-related morbidity and mortality. Given evidence for improved postsepsis outcomes in females…”
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Transcriptomic Changes Within Human Bone Marrow After Severe Trauma by Kelly, Lauren S., Apple, Camille G., Darden, Dijoia B., Kannan, Kolenkode B., Pons, Erick E., Fenner, Brittany P., Parvataneni, Hari K., Hagen, Jennifer E., Brakenridge, Scott C., Efron, Philip A., Mohr, Alicia M.

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Identification of Unique microRNA Expression Patterns in Bone Marrow Hematopoietic Stem and Progenitor Cells after Hemorrhagic Shock and Polytrauma in Young and Old Adult Mice by Darden, Dijoia B., Mira, Juan C., Lopez, Maria-Cecilia, Stortz, Julie A., Fenner, Brittany P., Kelly, Lauren S., Nacionales, Dina C., Budharaju, Ashrita, Loftus, Tyler J., Baker, Henry V., Moore, Frederick A., Brakenridge, Scott C., Moldawer, Lyle L., Mohr, Alicia M., Efron, Philip A.

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Evaluation of a Multivalent Transcriptomic Metric for Diagnosing Surgical Sepsis and Estimating Mortality Among Critically Ill Patients by Brakenridge, Scott C, Chen, Uan-I, Loftus, Tyler, Ungaro, Ricardo, Dirain, Marvin, Kerr, Austin, Zhong, Luer, Bacher, Rhonda, Starostik, Petr, Ghita, Gabriella, Midic, Uros, Darden, Dijoia, Fenner, Brittany, Wacker, James, Efron, Philip A, Liesenfeld, Oliver, Sweeney, Timothy E, Moldawer, Lyle L

“…Rapid and accurate discrimination of sepsis and its potential severity currently require multiple assays with slow processing times that are often inconclusive…”
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SEX DIFFERENCES ASSOCIATE WITH LATE MICROBIOME ALTERATIONS AFTER MURINE SURGICAL SEPSIS by Efron, Philip A., Darden, Dijoia B., Li, Eric C., Munley, Jennifer, Kelly, Lauren, Fenner, Brittany, Nacionales, Dina C., Ungaro, Ricardo F., Dirain, Marvin L., Rincon, Jaimar, Mankowski, Robert T., Leeuwenburgh, Christiaan, Moore, Frederick A., Brakenridge, Scott C., Foster, Thomas C., Laitano, Orlando, Casadesus, Gemma, Moldawer, Lyle L., Mohr, Alicia M., Thomas, Ryan M.

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