Search Results - "Fennell, T R"

Human exposure and internal dose assessments of acrylamide in food by Dybing, E., Farmer, P.B., Andersen, M., Fennell, T.R., Lalljie, S.P.D., Müller, D.J.G., Olin, S., Petersen, B.J., Schlatter, J., Scholz, G., Scimeca, J.A., Slimani, N., Törnqvist, M., Tuijtelaars, S., Verger, P.

“…This review provides a framework contributing to the risk assessment of acrylamide in food. It is based on the outcome of the ILSI Europe FOSIE process, a risk…”
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Comparison of the Hemoglobin Adducts Formed by Administration of N-Methylolacrylamide and Acrylamide to Rats by Fennell, Timothy R., Snyder, Rodney W., Krol, Wojciech L., Sumner, Susan C. J.

“…Acrylamide (AM) and N-methylolacrylamide (NMA) are used in the formulation of grouting materials. AM undergoes metabolism to a reactive epoxide, glycidamide…”
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Acute intravenous exposure to silver nanoparticles during pregnancy induces particle size and vehicle dependent changes in vascular tissue contractility in Sprague Dawley rats by Vidanapathirana, A.K., Thompson, L.C., Herco, M., Odom, J., Sumner, S.J., Fennell, T.R., Brown, J.M., Wingard, C.J.

“…•Use of Silver nanoparticles (AgNP) raises safety concerns during pregnancy.•Pregnant rats were studied 24h post-exposure to acute intravenous…”
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Attenuation of cocaine self-administration by chronic oral phendimetrazine in rhesus monkeys by Czoty, P.W, Blough, B.E, Fennell, T.R, Snyder, R.W, Nader, M.A

“…Highlights • Phendimetrazine (PDM) is a pro-drug for the amphetamine-like monoamine releaser phenmetrazine (PM). • Chronic oral PDM treatment decreased cocaine…”
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Hemoglobin Adducts from Acrylonitrile and Ethylene Oxide in Cigarette Smokers: Effects of Glutathione S-Transferase T1-Null and M1-Null Genotypes by FENNELL, T. R, MACNEELA, J. P, MORRIS, R. W, WATSON, M, THOMPSON, C. L, BELL, D. A

“…Acrylonitrile (ACN) is used to manufacture plastics and fibers. It is carcinogenic in rats and is found in cigarette smoke. Ethylene oxide (EO) is a metabolite…”
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Molecular dosimetry of ethylene oxide : formation and persistence of 7-(2-hydroxyethyl)guanine in DNA following repeated exposures of rats and mice by WALKER, V. E, FENNELL, T. R, UPTON, P. B, SKOPEK, T. R, RPEVOST, V, SHUKER, D. E. G, SWENBERG, J. A

“…The formation of 7-(2-hydroxyethyl)guanine (7-HEG) in DNA of target and nontarget tissues was investigated in male B6C3F1 mice (20/group) and F344 rats…”
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In vivo and in vitro kinetics of ethylene oxide metabolism in rats and mice by BROWN, C. D, WONG, B. A, FENNELL, T. R

“…Ethylene oxide (EO) is a direct-acting mutagen and animal carcinogen used as an industrial intermediate and sterilant with a high potential for human exposure…”
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Role of Cytochrome P450 2E1 in the Metabolism of Acrylamide and Acrylonitrile in Mice by Sumner, Susan C. J, Fennell, Timothy R, Moore, Timothy A, Chanas, Brian, Gonzalez, Frank, Ghanayem, Burhan I

“…Acrylonitrile (AN) and acrylamide (AM) are commonly used in the synthesis of plastics and polymers. In rodents, AM and AN are metabolized to the epoxides…”
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A critical review of the toxicology of glutaraldehyde by Beauchamp, Jr, R O, St Clair, M B, Fennell, T R, Clarke, D O, Morgan, K T, Kari, F W

“…Glutaraldehyde, a low molecular weight aldehyde, has been investigated for toxicity in humans and animals. Examination of this dialdehyde was indicated from…”
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Ethylene Oxide Dosimetry in the Mouse by Brown, Carl D., Asgharian, Bahman, Turner, Max J., Fennell, Timothy R.

“…Ethylene oxide (EO) is a direct-acting mutagen and animal carcinogen used as an industrial intermediate and sterilant with a high potential for human exposure…”
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A model for the formation and removal of hemoglobin adducts by Fennell, T R, Sumner, S C, Walker, V E

“…Hemoglobin adducts formed by chemical carcinogens can be used as biomarkers of exposure. The kinetics of adduct formation and removal is complex and depends on…”
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Acrylamide: A Comparison of Metabolism and Hemoglobin Adducts in Rodents following Dermal, Intraperitoneal, Oral, or Inhalation Exposure by Sumner, Susan C. J., Williams, Carla C., Snyder, Rodney W., Krol, Wojciech L., Asgharian, Bahman, Fennell, Timothy R.

“…Acrylamide (AM), which is used to manufacture polymers, is carcinogenic and a reproductive and neurological toxicant. The objective of this study was to…”
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Characterization of phosphodiester adducts produced by the reaction of cyanoethylene oxide with nucleotides by Yates, J M, Fennell, T R, Turner, Jr, M J, Recio, L, Sumner, S C

“…Cyanoethylene oxide (CEO), a putative toxic and carcinogenic metabolite of acrylonitrile, is a direct-acting mutagen. The focus of this study was to elucidate…”
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Metabolism and Disposition of Bisphenol A in Female Rats by Snyder, Rodney W., Maness, Susan C., Gaido, Kevin W., Welsch, Frank, Sumner, Susan C.J., Fennell, Timothy R.

“…Bisphenol A (BPA), which is used in the manufacture of polycarbonates, elicits weak estrogenic activity in in vitro and in vivo test systems. The objectives of…”
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Molecular Dosimetry of DNA and Hemoglobin Adducts in Mice and Rats Exposed to Ethylene Oxide by Walker, Vernon E., Fennell, Timothy R., Upton, Patricia B., MacNeela, John P., Swenberg, James A.

“…Experiments involving ethylene oxide (ETO) have been used to support the concept of using adducts in hemoglobin as a surrogate for DNA adducts in target…”
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Molecular dosimetry of ethylene oxide : formation and persistence of N-(2-hydroxyethyl)valine in hemoglobin following repeated exposures of rats and mice by WALKER, V. E, MACNEELA, J. P, SWENBERG, J. A, TURNER, M. J, FENNELL, T. R

“…The formation of N-(2-hydroxyethyl)valine (HEVal) in hemoglobin was investigated in male F344 rats (10/group) and B6C3F1 mice (20/group) exposed to 0, 3, 10,…”
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A Physiologically Based Dosimetry Description of Acrylonitrile and Cyanoethylene Oxide in the Rat by Gargas, M.L., Andersen, M.E., Teo, S.K.O., Batra, R., Fennell, T.R., Kedderis, G.L.

“…The cytochrome P450-mediated oxidation of acrylonitrile (ACN) to the mutagen 2-cyanoethylene oxide (CEO) is thought to be important for the carcinogenic…”
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Characterization of an adduct and its degradation product produced by the reaction of cyanoethylene oxide with deoxythymidine and DNA by Yates, J M, Summer, S C, Turner, Jr, M J, Recio, L, Fennell, T R

“…Cyanoethylene oxide (CEO), the putative toxic and carcinogenic metabolite of acrylonitrile, is a direct-acting mutagen. CEO reacted with deoxythymidine (dT) to…”
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Monitoring exposure to acrylonitrile using adducts with N-terminal valine in hemoglobin by Osterman-Golkar, S M, MacNeela, J P, Turner, M J, Walker, V E, Swenberg, J A, Sumner, S J, Youtsey, N, Fennell, T R

“…Human exposure to acrylonitrile (ACN), a carcinogen in rats, may occur in industrial settings, through waste water and tobacco smoke. ACN is an electrophilic…”
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Further characterization of the DNA adducts formed by electrophilic esters of the hepatocarcinogens 1'-hydroxysafrole and 1'-hydroxyestragole in vitro and in mouse liver in Vivo, including new adducts at C-8 and N-7 of guanine residues by WISEMAN, R. W, FENNELL, T. R, MILLER, J. A, MILLER, E. C

“…The identities of the adducts formed on reaction of the model electrophilic and carcinogenic esters 1'-acetoxysafrole or 1'-acetoxyestragole with…”
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