Search Results - "Fennell, Katie"

Epigenetic therapies in acute myeloid leukemia: where to from here? by Fennell, Katie A., Bell, Charles C., Dawson, Mark A.

“…A hallmark of acute myeloid leukemia (AML) is epigenetic dysregulation, which is initiated by recurrent translocations and/or mutations in transcription…”
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Non-genetic determinants of malignant clonal fitness at single-cell resolution by Fennell, Katie A., Vassiliadis, Dane, Lam, Enid Y. N., Martelotto, Luciano G., Balic, Jesse J., Hollizeck, Sebastian, Weber, Tom S., Semple, Timothy, Wang, Qing, Miles, Denise C., MacPherson, Laura, Chan, Yih-Chih, Guirguis, Andrew A., Kats, Lev M., Wong, Emily S., Dawson, Sarah-Jane, Naik, Shalin H., Dawson, Mark A.

“…All cancers emerge after a period of clonal selection and subsequent clonal expansion. Although the evolutionary principles imparted by genetic intratumour…”
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Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia by Bell, Charles C., Fennell, Katie A., Chan, Yih-Chih, Rambow, Florian, Yeung, Miriam M., Vassiliadis, Dane, Lara, Luis, Yeh, Paul, Martelotto, Luciano G., Rogiers, Aljosja, Kremer, Brandon E., Barbash, Olena, Mohammad, Helai P., Johanson, Timothy M., Burr, Marian L., Dhar, Arindam, Karpinich, Natalie, Tian, Luyi, Tyler, Dean S., MacPherson, Laura, Shi, Junwei, Pinnawala, Nathan, Yew Fong, Chun, Papenfuss, Anthony T., Grimmond, Sean M., Dawson, Sarah-Jane, Allan, Rhys S., Kruger, Ryan G., Vakoc, Christopher R., Goode, David L., Naik, Shalin H., Gilan, Omer, Lam, Enid Y. N., Marine, Jean-Christophe, Prinjha, Rab K., Dawson, Mark A.

“…Non-genetic drug resistance is increasingly recognised in various cancers. Molecular insights into this process are lacking and it is unknown whether stable…”
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Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses by Chan, Kah Lok, Gomez, Juliana, Cardinez, Chelisa, Kumari, Nishi, Sparbier, Christina E., Lam, Enid Y.N., Yeung, Miriam M., Garciaz, Sylvain, Kuzich, James A., Ong, Doen Ming, Brown, Fiona C., Chan, Yih-Chih, Vassiliadis, Dane, Wainwright, Elanor N., Motazedian, Ali, Gillespie, Andrea, Fennell, Katie A., Lai, Junyun, House, Imran G., Macpherson, Laura, Ang, Ching-Seng, Dawson, Sarah-Jane, Beavis, Paul A., Wei, Andrew H., Burr, Marian L., Dawson, Mark A.

“…There is increasing recognition of the prognostic significance of tumor cell major histocompatibility complex (MHC) class II expression in anti-cancer…”
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SPOP tips the balance of BETs in cancer by Fennell, Katie A, Dawson, Mark A

“…Cancer-associated mutations in speckle-type POZ (pox virus and zinc-finger) protein confer neomorphic activity, altering its substrate affinities and its…”
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Analysis of synthetic cellular barcodes in the genome and transcriptome with BARtab and bartools by Holze, Henrietta, Talarmain, Laure, Fennell, Katie A., Lam, Enid Y., Dawson, Mark A., Vassiliadis, Dane

“…Cellular barcoding is a lineage-tracing methodology that couples heritable synthetic barcodes to high-throughput sequencing, enabling the accurate tracing of…”
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Clonal analysis of fetal hematopoietic stem/progenitor cells reveals how post-transplantation capabilities are distributed by Stonehouse, Olivia J., Biben, Christine, Weber, Tom S., Garnham, Alexandra, Fennell, Katie A., Farley, Alison, Terreaux, Antoine F., Alexander, Warren S., Dawson, Mark A., Naik, Shalin H., Taoudi, Samir

“…It has been proposed that adult hematopoiesis is sustained by multipotent progenitors (MPPs) specified during embryogenesis. Adult-like hematopoietic stem cell…”
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Effect on gene expression of three allelic variants in GATA motifs of ABO, RHD, and RHCE regulatory elements by Fennell, Katie, Hoffman, Roser, Yoshida, Ken, Iwamoto, Sadahiko, Govender, Lavendri, Vather, Kuben, Sookraj, Ashika, Jentsch, Ute, Pambrun, Chantale, McAuley, Catherine, Keller, Margaret A., Ochoa‐Garay, Gorka

“…BACKGROUND Only a few genetic variants have been reported in regulatory elements of blood group genes. Most of them affect GATA motifs, binding sites for the…”
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3123 – DELINEATING THE HIERARCHICAL ORGANIZATION AND LINEAGE HETEROGENEITY OF THE MOUSE HSC AND MPP NETWORK by Lin, Dawn, Sommerkamp, Pia, Narr, Andreas, Fennell, Katie, Vassiliadis, Dane, naik, Shalin, Dawson, Mark, Trumpp, Andreas

“…The Lin–Sca1+cKit+ (LSK) compartment of the mouse bone marrow contains the most primitive hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs),…”
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3128 – SINGLE-CELL ANALYSIS OF FOETAL LIVER STEM AND PROGENITOR CELLS REVEALS IMMUNOPHENOTYPICALLY HIDDEN LONG-TERM RECONSTITUTING HSCS by Stonehouse, Olivia, Biben, Christine, Fennell, Katie, Garnham, Alexandra, Weber, Tom, Taoudi, Samir

“…Haematopoiesis or blood formation is an ongoing process throughout life, with haematopoietic stem cells (HSCs) and high-end progenitors acting at the…”
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RH genotyping by nonspecific quantitative next‐generation sequencing by Stef, Marianne, Fennell, Katie, Apraiz, Izaskun, Arteta, David, González, Cecilia, Nogués, Nuria, Ochoa‐Garay, Gorka

“…Background Conventional sequencing uses gene‐specific primers to determine the location of RH variants and permits a qualitative assessment of zygosity…”
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3006 – IN VIVO CLONAL TRACKING REVEALS EVIDENCE OF HAEMANGIOBLAST AND HAEMATOMESOBLAST CONTRIBUTION TO YOLK SAC HAEMATOPOIESIS by Biben, Christine, Weber, Tom, Potts, Kathy, Choi, Jarny, Miles, Denise, Carmagnac, Amandine, Sargent, Tobias, de Graaf, Carolyn, Fennell, Katie, Farley, Alison, Stonehouse, Olivia, Dawson, Mark, Hilton, Douglas, Naik, Shalin, Taoudi, Samir

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2017 – THE MESODERMAL LINEAGES OF THE YOLK SAC ARE SEEDED BY HAEMANGIOBLAST, HAEMATOMESOBLAST, AND MESENCHYMOANGIOBLAST PRECURSORS by Biben, Christine, Weber, Tom, Potts, Kathryn, Choi, Jarny, Miles, Denise, Carmagnac, Amandine, Sargent, Tobias, de Graaf, Carolyn, Fennell, Katie, Farley, Alison, Stonehouse, Olivia, Dawson, Mark, Hilton, Douglas, Naik, Shalin, Taoudi, Samir

“…During embryogenesis, haematopoietic and endothelial lineages emerge closely in time and space, making understanding their lineage relationship difficult. It…”
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Abstract C044: Single cell RNA-sequencing coupled with lineage tracing identifies novel clonal populations associated with immunotherapy resistance by Saleh, Reem, Patel, Riyaben, Vassiliadis, Dane, Hammal, Fayrouz, Blyth, Benjamin, Du, Xin, Fennell, Katie, Dawson, Mark A., McArthur, Grant A., Sheppard, Karen

“…Abstract Although immune checkpoint inhibitors (ICIs) have revolutionized melanoma treatment, many individuals either show no response or eventually develop…”
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Abstract B001: Intra- and inter-tumoral heterogeneity of melanoma across different metastatic sites by Aedo Lopez, Veronica L., Saleh, Reem, Blyth, Benjamin, Du, Xin, Vassiliadis, Dane, Fennell, Katie, Moi, Davide, Mazzieri, Roberta, Dolcetti, Riccardo, Sheppard, Karen E., McArthur, Grant A.

“…Abstract Melanoma, a highly metastatic skin cancer, exhibits variations in prognosis and response to therapy based on the site of metastasis. Despite the…”
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A GYPB variant encoding an altered leader peptide leads to a weak S phenotype by Cote, Jacqueline, Cen, Selena, Fennell, Katie, Pambrun, Chantale, Branch, Donald R., Ochoa‐Garay, Gorka

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Two new RHD alleles with deletions spanning multiple exons by Matteocci, Antonella, Monge‐Ruiz, Jorge, Stef, Marianne, Apraiz, Izaskun, Herrera‐del‐Val, Lara, Mancuso, Tommaso, Fennell, Katie, Lopez, Monica, Larizgoitia‐Martin, Yolanda, Nespoli, Guido, Rubia‐Tejero, Montserrat, Collaretti, Angela, Pierelli, Luca, Ochoa‐Garay, Gorka

“…Background The most common large‐deletion RHD allele (RHD*01N.01) includes the entire coding sequence, intervening regions and untranslated regions. The rest…”
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Abstract 3110: CBF regulates cell senescence and autophagy through sphingolipid metabolism by Greer, Adam H., Yong, Thomas, Fennell, Katie, Meyers, Shari, Davis, Nathan

“…Abstract Core Binding Factor (CBF) is a heterodimeric transcription factor comprised of one of three RUNX DNA binding proteins (Runx1, Runx2, or Runx3) and a…”
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Knockdown of core binding factor[beta] alters sphingolipid metabolism by Greer, Adam H, Yong, Thomas, Fennell, Katie, Moustafa, Yara W, Fowler, Marcie, Galiano, Floyd, Ng, Shu-Wing, Berkowitz, Ross S, Cardelli, James, Meyers, Shari, Davis, J Nathan

“…Core binding factor (CBF) is a heterodimeric transcription factor containing one of three DNA-binding proteins of the Runt-related transcription factor family…”
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Knockdown of core binding factorβ alters sphingolipid metabolism by Greer, Adam H., Yong, Thomas, Fennell, Katie, Moustafa, Yara W., Fowler, Marcie, Galiano, Floyd, Ng, Shu-Wing, Berkowitz, Ross S., Cardelli, James, Meyers, Shari, Davis, J. Nathan

“…Core binding factor (CBF) is a heterodimeric transcription factor containing one of three DNA‐binding proteins of the Runt‐related transcription factor family…”
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