Search Results - "Feng, William W"

CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies by Feng, William W., Wilkins, Owen, Bang, Scott, Ung, Matthew, Li, Jiaqi, An, Jennifer, del Genio, Carmen, Canfield, Kaleigh, DiRenzo, James, Wells, Wendy, Gaur, Arti, Robey, R. Brooks, Guo, Jessie Yanxiang, Powles, Ryan L., Sotiriou, Christos, Pusztai, Lajos, Febbraio, Maria, Cheng, Chao, Kinlaw, William B., Kurokawa, Manabu

“…Although it is established that fatty acid (FA) synthesis supports anabolic growth in cancer, the role of exogenous FA uptake remains elusive. Here we show…”
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The Role of CD36 in Cancer Progression and Its Value as a Therapeutic Target by Feng, William W, Zuppe, Hannah T, Kurokawa, Manabu

“…Cluster of differentiation 36 (CD36) is a cell surface scavenger receptor that plays critical roles in many different types of cancer, notably breast, brain,…”
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Endocytosis of very low-density lipoproteins: an unexpected mechanism for lipid acquisition by breast cancer cells[S] by Lupien, Leslie E., Bloch, Katarzyna, Dehairs, Jonas, Traphagen, Nicole A., Feng, William W., Davis, Wilson L., Dennis, Thea, Swinnen, Johannes V., Wells, Wendy A., Smits, Nicole C., Kuemmerle, Nancy B., Miller, Todd W., Kinlaw, William B.

“…We previously described the expression of CD36 and LPL by breast cancer (BC) cells and tissues and the growth-promoting effect of VLDL observed only in the…”
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An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer by To, Ciric, Beyett, Tyler S, Jang, Jaebong, Feng, William W, Bahcall, Magda, Haikala, Heidi M, Shin, Bo H, Heppner, David E, Rana, Jaimin K, Leeper, Brittaney A, Soroko, Kara M, Poitras, Michael J, Gokhale, Prafulla C, Kobayashi, Yoshihisa, Wahid, Kamal, Kurppa, Kari J, Gero, Thomas W, Cameron, Michael D, Ogino, Atsuko, Mushajiang, Mierzhati, Xu, Chunxiao, Zhang, Yanxi, Scott, David A, Eck, Michael J, Gray, Nathanael S, Jänne, Pasi A

“…Epidermal growth factor receptor (EGFR) therapy using small-molecule tyrosine kinase inhibitors (TKIs) is initially efficacious in patients with EGFR-mutant…”
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CD36: a key mediator of resistance to HER2 inhibitors in breast cancer by Feng, William W., Bang, Scott, Kurokawa, Manabu

“…Acquired resistance to anti-HER2 therapy is a significant clinical challenge in breast cancer. We recently discovered that during acquisition of resistance to…”
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Hepatic Huwe1 loss protects mice from non-alcoholic fatty liver disease through lipid metabolic rewiring by Feng, William W., Bang, Scott, Takacs, Eric M., Day, Cora, Crawford, Katherine J., Al-Sheyab, Ruba, Almufarrej, Dara B., Wells, Wendy, Ilchenko, Serguei, Kasumov, Takhar, Kon, Ning, Novak, Colleen M., Gu, Wei, Kurokawa, Manabu

“…Non-alcoholic fatty liver disease (NAFLD) is the most pervasive liver pathology worldwide. Here, we demonstrate that the ubiquitin E3 ligase Huwe1 is vital in…”
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Transferrin receptor targeting chimeras for membrane protein degradation by Zhang, Dingpeng, Duque-Jimenez, Jhoely, Facchinetti, Francesco, Brixi, Garyk, Rhee, Kaitlin, Feng, William W, Jänne, Pasi A, Zhou, Xin

“…Cancer cells require high levels of iron for rapid proliferation, leading to significant upregulation of cell-surface transferrin receptor 1 (TfR1), which…”
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Lipid metabolic reprogramming as an emerging mechanism of resistance to kinase inhibitors in breast cancer by Feng, William W, Kurokawa, Manabu

“…Breast cancer is one of the leading causes of death in women in the United States. In general, patients with breast cancer undergo surgical resection of the…”
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Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer by de Miguel, Fernando J., Gentile, Claudia, Feng, William W., Silva, Shannon J., Sankar, Akshay, Exposito, Francisco, Cai, Wesley L., Melnick, Mary Ann, Robles-Oteiza, Camila, Hinkley, Madeline M., Tsai, Jeanelle A., Hartley, Antja-Voy, Wei, Jin, Wurtz, Anna, Li, Fangyong, Toki, Maria I., Rimm, David L., Homer, Robert, Wilen, Craig B., Xiao, Andrew Z., Qi, Jun, Yan, Qin, Nguyen, Don X., Jänne, Pasi A., Kadoch, Cigall, Politi, Katerina A.

“…Acquired resistance to tyrosine kinase inhibitors (TKI), such as osimertinib used to treat EGFR-mutant lung adenocarcinomas, limits long-term efficacy and is…”
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Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19 by Amrhein, Jennifer A., Beyett, Tyler S., Feng, William W., Krämer, Andreas, Weckesser, Janik, Schaeffner, Ilse K., Rana, Jaimin K., Jänne, Pasi A., Eck, Michael J., Knapp, Stefan, Hanke, Thomas

“…Activating mutations in the epidermal growth factor receptor (EGFR) are frequent oncogenic drivers of non-small-cell lung cancer (NSCLC). The most frequent…”
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X-Linked Huwe1 Is Essential for Oocyte Maturation and Preimplantation Embryo Development by Eisa, Alaa A., Bang, Scott, Crawford, Katherine J., Murphy, Emily M., Feng, William W., Dey, Souvik, Wells, Wendy, Kon, Ning, Gu, Wei, Mehlmann, Lisa M., Vijayaraghavan, Srinivasan, Kurokawa, Manabu

“…HUWE1 is a HECT-domain ubiquitin E3 ligase expressed in various tissues. Although HUWE1 is known to promote degradation of the tumor suppressor p53, given a…”
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Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors by Pecci, Federica, Nakazawa, Seshiru, Ricciuti, Biagio, Harada, Guilherme, Lee, Jessica K, Alessi, Joao V, Barrichello, Adriana, Vaz, Victor R, Lamberti, Giuseppe, Di Federico, Alessandro, Gandhi, Malini M, Gazgalis, Dimitris, Feng, William W, Jiang, Jie, Baldacci, Simon, Locquet, Marie-Anaïs, Gottlieb, Felix H, Chen, Monica F, Lee, Elinton, Haradon, Danielle, Smokovich, Anna, Voligny, Emma, Nguyen, Tom, Goel, Vikas K, Zimmerman, Zachary, Atwal, Sumandeep, Wang, Xinan, Bahcall, Magda, Heist, Rebecca S, Iqbal, Sumaiya, Gandhi, Nishant, Elliott, Andrew, Vanderwalde, Ari M, Ma, Patrick C, Halmos, Balazs, Liu, Stephen V, Che, Jianwei, Schrock, Alexa B, Drilon, Alexander, Jänne, Pasi A, Awad, Mark M

“…Activating point mutations in the MET tyrosine kinase domain (TKD) are oncogenic in a subset of papillary renal cell carcinomas. Here, using comprehensive…”
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Parsing digital or analog TCR performance through piconewton forces by Akitsu, Aoi, Kobayashi, Eiji, Feng, Yinnian, Stephens, Hannah M, Brazin, Kristine N, Masi, Daniel J, Kirkpatrick, Evan H, Mallis, Robert J, Duke-Cohan, Jonathan S, Booker, Matthew A, Cinella, Vincenzo, Feng, William W, Holliday, Elizabeth L, Lee, Jonathan J, Zienkiewicz, Katarzyna J, Tolstorukov, Michael Y, Hwang, Wonmuk, Lang, Matthew J, Reinherz, Ellis L

“…αβ T cell receptors (TCRs) principally recognize aberrant peptides bound to major histocompatibility complex molecules (pMHCs) on unhealthy cells, amplifying…”
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VISCOELASTIC BEHAVIORS AND COMPUTING MODELS OF THE SPINAL CORD by Shiau, Jyh-Kun, Chang, Kuang-Liang, Hung, Tin-Kan, Feng, William W

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An in-vivo measurement and analysis of viscoelastic properties of the spinal cord of cats by Chang, G L, Hung, T K, Feng, W W

“…An in-vivo experimental technique was employed to determine the linear and nonlinear characteristics of viscoelastic properties of the spinal cord of…”
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Macrocyclization of quinazoline-based EGFR inhibitors lead to exclusive mutant selectivity for EGFR L858R and Del19 by Amrhein, Jennifer A., Beyett, Tyler S., Feng, William W., Krämer, Andreas, Weckesser, Janik, Schaeffner, Ilse K., Rana, Jaimin K., Jänne, Pasi A., Eck, Michael J., Knapp, Stefan, Hanke, Thomas

“…Activating mutations in epidermal growth factor receptor (EGFR) are frequent oncogenic drivers of non-small-cell lung cancer (NSCLC). The most frequent…”
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Lipid Metabolic Reprogramming: Implications in Development of Cancer Drug Resistance and Nonalcoholic Fatty Liver Disease by Feng, William W

“…Dysregulated lipid metabolism contributes to the development and progression of many diseases. Breast cancer is the most common malignancy afflicting women…”
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Allosteric inhibition of drug resistant forms of EGFR L858R mutant NSCLC by To, Ciric, Beyett, Tyler S., Jang, Jaebong, Feng, William W., Bahcall, Magda, Haikala, Heidi M., Shin, Bo H., Heppner, David E., Rana, Jaimin K., Leeper, Brittaney A., Soroko, Kara M., Poitras, Michael J., Gokhale, Prafulla C., Kobayashi, Yoshihisa, Wahid, Kamal, Kurppa, Kari J., Gero, Thomas W., Cameron, Michael D., Ogino, Atsuko, Mushajiang, Mierzhati, Xu, Chunxiao, Zhang, Yanxi, Scott, David A., Eck, Michael J., Gray, Nathanael S., Jänne, Pasi A.

“…Although treatment with small molecule epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is initially efficacious for patients with…”
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Large plane deformations of rectangular elastic sheets by Feng, William W., Tielking, John T.

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