A new chromone derivative from an endophytic Aspergillus sp. GXNU-B1

A new chromone derivative from an endophytic Aspergillus sp. GXNU-B1

A new chromone derivative, aspergione A (1), along with seven known metabolites, was isolated from a mangrove endophytic fungus, Aspergillus sp. GXNU-B1, which was collected from mangrove Acanthus ilicifolius L. Their structures and the absolute configuration of 1 were elucidated based on the analys...

Full description

Saved in:
Bibliographic Details
Published in:Natural product research Vol. 38; no. 14; pp. 2474 - 2479
Main Authors: Feng, Aijuan, Zhang, Wenxiu, Wang, Lixia, Zhou, Junqiang, Chen, Jinwei, Xu, Xiaoyun, Huang, Xishan, Huang, Jiguo
Format: Journal Article
Language:English
Published: England Taylor & Francis 17-07-2024
Taylor & Francis Ltd
Subjects:
Absolute configuration
anti-inflammatory effect
Aspergillus
Aspergillus sp
aspergione A
Endophytes
Inflammation
Macrophages
mangrove endophytic fungus
Metabolites
NMR
Nuclear magnetic resonance
Aspergillus sp
anti-inflammatory effect
aspergione A
mangrove endophytic fungus
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new chromone derivative, aspergione A (1), along with seven known metabolites, was isolated from a mangrove endophytic fungus, Aspergillus sp. GXNU-B1, which was collected from mangrove Acanthus ilicifolius L. Their structures and the absolute configuration of 1 were elucidated based on the analysis of HR-ESI-MS, NMR, and ECD calculation. Compounds 1-8 were evaluated for their anti-inflammatory effects on the production of nitricoxide (NO). Compounds 1 and 8 have potent inhibitory effects against NO production in activated macrophages with IC 50 values of 38.26 and 44.30 μM, respectively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1478-6419
1478-6427
1478-6427
DOI:10.1080/14786419.2023.2181805