Search Results - "Feneley, Michael P"

High-Frequency Echocardiography　― Transformative Clinical and Research Applications in Humans, Mice, and Zebrafish by Wang, Louis W., Kesteven, Scott H., Huttner, Inken G., Feneley, Michael P., Fatkin, Diane

“…Echocardiography is an invaluable tool for characterizing cardiac structure and function in vivo. Technological advances in high-frequency ultrasound over the…”
Get full text

Standardized echocardiographic assessment of cardiac function in normal adult zebrafish and heart disease models by Wang, Louis W, Huttner, Inken G, Santiago, Celine F, Kesteven, Scott H, Yu, Ze-Yan, Feneley, Michael P, Fatkin, Diane

“…The zebrafish (Danio rerio) is an increasingly popular model organism in cardiovascular research. Major insights into cardiac developmental processes have been…”
Get full text

The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy by Guo, Yang, Yu, Ze-Yan, Wu, Jianxin, Gong, Hutao, Kesteven, Scott, Iismaa, Siiri E, Chan, Andrea Y, Holman, Sara, Pinto, Silvia, Pironet, Andy, Cox, Charles D, Graham, Robert M, Vennekens, Rudi, Feneley, Michael P, Martinac, Boris

“…Pathological left ventricular hypertrophy (LVH) occurs in response to pressure overload and remains the single most important clinical predictor of cardiac…”
Get full text

Neuregulin 1 Sustains the Gene Regulatory Network in Both Trabecular and Nontrabecular Myocardium by Lai, Donna, Liu, Xifu, Forrai, Ariel, Wolstein, Orit, Michalicek, Jan, Ahmed, Ishtiaq, Garratt, Alistair N, Birchmeier, Carmen, Zhou, Mingdong, Hartley, Lynne, Robb, Lorraine, Feneley, Michael P, Fatkin, Diane, Harvey, Richard P

“…RATIONALE:The cardiac gene regulatory network (GRN) is controlled by transcription factors and signaling inputs, but network logic in development and it…”
Get full text

Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice by Nikolova, Vesna, Leimena, Christiana, McMahon, Aisling C, Tan, Ju Chiat, Chandar, Suchitra, Jogia, Dilesh, Kesteven, Scott H, Michalicek, Jan, Otway, Robyn, Verheyen, Fons, Rainer, Stephen, Stewart, Colin L, Martin, David, Feneley, Michael P, Fatkin, Diane

“…Laminopathies are a group of disorders caused by mutations in the LMNA gene that encodes the nuclear lamina proteins, lamin A and lamin C; their…”
Get full text

Irreversible Triggers for Hypertrophic Cardiomyopathy Are Established in the Early Postnatal Period by Cannon, Leah, PhD, Yu, Ze-Yan, MBBS, PhD, Marciniec, Tadeusz, PhD, Waardenberg, Ashley J., PhD, Iismaa, Siiri E., PhD, Nikolova-Krstevski, Vesna, PhD, Neist, Elysia, B Biotech (Hons), Ohanian, Monique, BMedSci (Hons), Qiu, Min Ru, MBBS, PhD, Rainer, Stephen, MBBS, Harvey, Richard P., PhD, Feneley, Michael P., MD, Graham, Robert M., MD, Fatkin, Diane, MD

“…Abstract Background Hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein genes, and left ventricular hypertrophy (LVH) develops as an…”
Get full text

Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations by Li, Jinyuan Vero, Ng, Chai-Ann, Cheng, Delfine, Zhou, Zijing, Yao, Mingxi, Guo, Yang, Yu, Ze-Yan, Ramaswamy, Yogambha, Ju, Lining Arnold, Kuchel, Philip W., Feneley, Michael P., Fatkin, Diane, Cox, Charles D.

“…Mechanosensitive channels are integral membrane proteins that sense mechanical stimuli. Like most plasma membrane ion channel proteins they must pass through…”
Get full text

Snowflakes in the heart: an ultrasonic marker of severe hypercoagulability by Wang, Louis W, MM, Grygiel, John J, MD, O'Neill, John H, MD, Fatkin, Diane, Prof, Feneley, Michael P, Prof

“…A 58-year-old woman with metastatic breast cancer and Coombs-positive autoimmune haemolytic anaemia presented in April, 2014, after developing right arm…”
Get full text

Machine learning prediction of progressive subclinical myocardial dysfunction in moderate aortic stenosis by Namasivayam, Mayooran, Meredith, Thomas, Muller, David W M, Roy, David A, Roy, Andrew K, Kovacic, Jason C, Hayward, Christopher S, Feneley, Michael P

“…Moderate severity aortic stenosis (AS) is poorly understood, is associated with subclinical myocardial dysfunction, and can lead to adverse outcome rates that…”
Get full text

A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance by Huttner, Inken G, Wang, Louis W, Santiago, Celine F, Horvat, Claire, Johnson, Renee, Cheng, Delfine, von Frieling-Salewsky, Marion, Hillcoat, Karen, Bemand, Timothy J, Trivedi, Gunjan, Braet, Filip, Hesselson, Dan, Alford, Kevin, Hayward, Christopher S, Seidman, J G, Seidman, Christine E, Feneley, Michael P, Linke, Wolfgang A, Fatkin, Diane

“…Background Truncating variants in the TTN gene ( TTNtv) are common in patients with dilated cardiomyopathy (DCM) but also occur in the general population…”
Get full text

Cardiac Gq Receptors and Calcineurin Activation Are Not Required for the Hypertrophic Response to Mechanical Left Ventricular Pressure Overload by Yu, Ze-Yan, Gong, Hutao, Wu, Jianxin, Dai, Yun, Kesteven, Scott H, Fatkin, Diane, Martinac, Boris, Graham, Robert M, Feneley, Michael P

“…Gq-coupled receptors are thought to play a critical role in the induction of left ventricular hypertrophy (LVH) secondary to pressure overload, although…”
Get full text

Effects of Mechanical Stress and Carvedilol in Lamin A/C–Deficient Dilated Cardiomyopathy by Chandar, Suchitra, Yeo, Li Sze, Leimena, Christiana, Tan, Ju-Chiat, Xiao, Xiao-Hui, Nikolova-Krstevski, Vesna, Yasuoka, Yoshinori, Gardiner-Garden, Margaret, Wu, Jianxin, Kesteven, Scott, Karlsdotter, Lina, Natarajan, Shweta, Carlton, Arthur, Rainer, Stephen, Feneley, Michael P, Fatkin, Diane

“…RATIONALE:Mutations in the LMNA gene, which encodes the nuclear lamina proteins lamin A and lamin C, are the most common cause of familial dilated…”
Get full text

Pressure Overload by Transverse Aortic Constriction Induces Maladaptive Hypertrophy in a Titin-Truncated Mouse Model by Harvey, Richard P., Gramlich, Michael, Gawaz, Meinrad, Aidery, Parwez, Wu, Jianxin, Kesteven, Scott, Zhou, Qifeng, Feneley, Michael P.

“…Mutations in the giant sarcomeric protein titin (TTN) are a major cause for inherited forms of dilated cardiomyopathy (DCM). We have previously developed a…”
Get full text

Combined mutation screening of NKX2-5, GATA4, and TBX5 in congenital heart disease: multiple heterozygosity and novel mutations by Granados-Riveron, Javier T, Pope, Mark, Bu'lock, Frances A, Thornborough, Christopher, Eason, Jacqueline, Setchfield, Kerry, Ketley, Ami, Kirk, Edwin P, Fatkin, Diane, Feneley, Michael P, Harvey, Richard P, Brook, J David

“…Background.  Variants of several genes encoding transcription modulators, signal transduction, and structural proteins are known to cause Mendelian congenital…”
Get more information

RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility by Yu, Ze-Yan, Tan, Ju-Chiat, McMahon, Aisling C, Iismaa, Siiri E, Xiao, Xiao-Hui, Kesteven, Scott H, Reichelt, Melissa E, Mohl, Marion C, Smith, Nicola J, Fatkin, Diane, Allen, David, Head, Stewart I, Graham, Robert M, Feneley, Michael P

“…To determine the mechanisms by which the α1A-adrenergic receptor (AR) regulates cardiac contractility. We reported previously that transgenic mice with…”
Get full text

Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk by Nikolova-Krstevski, Vesna, PhD, Wagner, Soeren, MD, Yu, Ze Yan, MD, Cox, Charles D., PhD, Cvetkovska, Jasmina, BSc, Hill, Adam P., PhD, Huttner, Inken G., MD, Benson, Victoria, PhD, Werdich, Andreas A., PhD, MacRae, Calum, MD, PhD, Feneley, Michael P., MD, PhD, Friedrich, Oliver, PhD, Martinac, Boris, PhD, Fatkin, Diane, MD

“…Visual Abstract…”
Get full text

Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control by Coleman, James L J, Mouat, Margaret A, Wu, Jianxin, Jancovski, Nikola, Bassi, Jaspreet K, Chan, Andrea Y, Humphreys, David T, Mrad, Nadine, Yu, Ze-Yan, Ngo, Tony, Iismaa, Siiri, Dos Remedios, Cristobal G, Feneley, Michael P, Allen, Andrew M, Graham, Robert M, Smith, Nicola J

“…Over 100 mammalian G protein-coupled receptors are yet to be matched with endogenous ligands; these so-called orphans are prospective drug targets for the…”
Get full text

Evaluation of Left Ventricular Enlargement as a Marker of Early Disease in Familial Dilated Cardiomyopathy by Fatkin, Diane, Yeoh, Thomas, Hayward, Christopher S, Benson, Victoria, Sheu, Angela, Richmond, Zara, Feneley, Michael P, Keogh, Anne M, Macdonald, Peter S

“…BACKGROUND—Echocardiographic screening of families with dilated cardiomyopathy has identified a subgroup of asymptomatic relatives with left ventricular…”
Get full text

Pulmonary arteriovenous malformation: an unusual cause of exertional dyspnoea by Wang, Louis W, Dr, Kotlyar, Eugene, MD, Bester, Lourens, MMed, Feneley, Michael P, Prof, Omari, Abdullah, Prof, Subbiah, Rajesh N, PhD

“…PAVMs are usually congenital in origin, but may be acquired in various conditions, such as cirrhosis, trauma, mitral stenosis, and schistosomiasis.1 Although…”
Get full text

Reproducibility of adenosine stress cardiovascular magnetic resonance in multi-vessel symptomatic coronary artery disease by Chih, Sharon, Macdonald, Peter S, Feneley, Michael P, Law, Matthew, Graham, Robert M, McCrohon, Jane A

“…First-pass perfusion cardiovascular magnetic resonance (CMR) is increasingly being utilized in both clinical practice and research. However, the…”
Get full text