Search Results - "Fendler, Annika"

Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients by Fendler, Annika, Bauer, Daniel, Busch, Jonas, Jung, Klaus, Wulf-Goldenberg, Annika, Kunz, Severine, Song, Kun, Myszczyszyn, Adam, Elezkurtaj, Sefer, Erguen, Bettina, Jung, Simone, Chen, Wei, Birchmeier, Walter

“…Current treatments for clear cell renal cell cancer (ccRCC) are insufficient because two-thirds of patients with metastases progress within two years. Here we…”
Get full text

COVID-19 vaccines in patients with cancer: immunogenicity, efficacy and safety by Fendler, Annika, de Vries, Elisabeth G. E., GeurtsvanKessel, Corine H., Haanen, John B., Wörmann, Bernhard, Turajlic, Samra, von Lilienfeld-Toal, Marie

“…Patients with cancer have a higher risk of severe coronavirus disease (COVID-19) and associated mortality than the general population. Owing to this increased…”
Get full text

Discordant Health Implications and Molecular Mechanisms of Vitamin D in Clinical and Preclinical Studies of Prostate Cancer: A Critical Appraisal of the Literature Data by Fendler, Annika, Stephan, Carsten, Ralla, Bernhard, Jung, Klaus

“…Clinical and preclinical studies have provided conflicting data on the postulated beneficial effects of vitamin D in patients with prostate cancer. In this…”
Get full text

Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2 by Au, Lewis, Fendler, Annika, Shepherd, Scott T. C., Rzeniewicz, Karolina, Cerrone, Maddalena, Byrne, Fiona, Carlyle, Eleanor, Edmonds, Kim, Del Rosario, Lyra, Shon, John, Haynes, Winston A., Ward, Barry, Shum, Ben, Gordon, William, Gerard, Camille L., Xie, Wenyi, Joharatnam-Hogan, Nalinie, Young, Kate, Pickering, Lisa, Furness, Andrew J. S., Larkin, James, Harvey, Ruth, Kassiotis, George, Gandhi, Sonia, Swanton, Charles, Fribbens, Charlotte, Wilkinson, Katalin A., Wilkinson, Robert J., Lau, David K., Banerjee, Susana, Starling, Naureen, Chau, Ian, Turajlic, Samra

“…Patients with cancer are currently prioritized in coronavirus disease 2019 (COVID-19) vaccination programs globally, which includes administration of mRNA…”
Get full text

MicroRNAs as Regulators of Signal Transduction in Urological Tumors by FENDLER, Annika, STEPHAN, Carsten, YOUSEF, George M, JUNG, Klaus

“…MicroRNAs (miRNAs) are short noncoding RNAs that have been shown to play pivotal roles in carcinogenesis. In the past decade, miRNAs have been the focus of…”
Get full text

Mice with renal-specific alterations of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors by Myszczyszyn, Adam, Popp, Oliver, Kunz, Severine, Sporbert, Anje, Jung, Simone, Penning, Louis C, Fendler, Annika, Mertins, Philipp, Birchmeier, Walter

“…Previously, we found that Wnt and Notch signaling govern stem cells of clear cell kidney cancer (ccRCC) in patients. To mimic stem cell responses in the normal…”
Get full text

The antiapoptotic function of miR-96 in prostate cancer by inhibition of FOXO1 by Fendler, Annika, Jung, Monika, Stephan, Carsten, Erbersdobler, Andreas, Jung, Klaus, Yousef, George M

“…microRNAs (miRNAs) are small molecules that regulate gene expression posttranscriptionally. In a previous study, we identified miR-96 to be upregulated in…”
Get full text

Circular RNAs and Their Linear Transcripts as Diagnostic and Prognostic Tissue Biomarkers in Prostate Cancer after Prostatectomy in Combination with Clinicopathological Factors by Rochow, Hannah, Jung, Monika, Weickmann, Sabine, Ralla, Bernhard, Stephan, Carsten, Elezkurtaj, Sefer, Kilic, Ergin, Zhao, Zhongwei, Jung, Klaus, Fendler, Annika, Franz, Antonia

“…As new biomarkers, circular RNAs (circRNAs) have been largely unexplored in prostate cancer (PCa). Using an integrative approach, we aimed to evaluate the…”
Get full text

A Novel Predictor Tool of Biochemical Recurrence after Radical Prostatectomy Based on a Five-MicroRNA Tissue Signature by Zhao, Zhongwei, Weickmann, Sabine, Jung, Monika, Lein, Michael, Kilic, Ergin, Stephan, Carsten, Erbersdobler, Andreas, Fendler, Annika, Jung, Klaus

“…Within five to ten years after radical prostatectomy (RP), approximately 15–34% of prostate cancer (PCa) patients experience biochemical recurrence (BCR),…”
Get full text

MiR-133b targets antiapoptotic genes and enhances death receptor-induced apoptosis by Patron, Juan P, Fendler, Annika, Bild, Matthias, Jung, Ulrike, Müller, Henrik, Arntzen, Magnus Ø, Piso, Chloe, Stephan, Carsten, Thiede, Bernd, Mollenkopf, Hans-Joachim, Jung, Klaus, Kaufmann, Stefan H E, Schreiber, Jörg

“…Despite the importance of microRNAs (miRs) for regulation of the delicate balance between cell proliferation and death, evidence for their specific involvement…”
Get full text

Selection of metastasis competent subclones in the tumour interior by Zhao, Yue, Fu, Xiao, Lopez, Jose I., Rowan, Andrew, Au, Lewis, Fendler, Annika, Hazell, Steve, Xu, Hang, Horswell, Stuart, Shepherd, Scott T. C., Spain, Lavinia, Byrne, Fiona, Stamp, Gordon, O’Brien, Tim, Nicol, David, Augustine, Marcellus, Chandra, Ashish, Rudman, Sarah, Toncheva, Antonia, Pickering, Lisa, Sahai, Erik, Larkin, James, Bates, Paul A., Swanton, Charles, Turajlic, Samra, Litchfield, Kevin

“…The genetic evolutionary features of solid tumour growth are becoming increasingly well described, but the spatial and physical nature of subclonal growth…”
Get full text

PD-L1 expression in tumor and inflammatory cells is associated with favorable tumor features and favorable prognosis in muscle-invasive urothelial carcinoma of the bladder not treated by immune checkpoint inhibitors by Plage, Henning, Furlano, Kira, Hofbauer, Sebastian, Weinberger, Sarah, Ralla, Bernhard, Franz, Antonia, Fendler, Annika, de Martino, Michela, Roßner, Florian, Elezkurtaj, Sefer, Kluth, Martina, Lennartz, Maximilian, Blessin, Niclas C, Marx, Andreas H, Samtleben, Henrik, Fisch, Margit, Rink, Michael, Slojewski, Marcin, Kaczmarek, Krystian, Ecke, Thorsten, Hallmann, Steffen, Koch, Stefan, Adamini, Nico, Zecha, Henrik, Minner, Sarah, Simon, Ronald, Sauter, Guido, Weischenfeldt, Joachim, Klatte, Tobias, Schlomm, Thorsten, Horst, David, Schallenberg, Simon

“…A high level of PD-L1 expression is the most relevant predictive parameter for response to immune checkpoint inhibitor (CPI) therapy in urinary bladder cancer…”
Get full text

Reduced p63 expression is linked to unfavourable prognosis in muscle‐invasive urothelial carcinoma of the bladder by Furlano, Kira, Plage, Henning, Hofbauer, Sebastian, Weinberger, Sarah, Ralla, Bernhard, Fendler, Annika, Roßner, Florian, Schallenberg, Simon, Elezkurtaj, Sefer, Kluth, Martina, Lennartz, Maximilian, Blessin, Niclas C., Marx, Andreas H., Samtleben, Henrik, Fisch, Margit, Rink, Michael, Slojewski, Marcin, Kaczmarek, Krystian, Ecke, Thorsten, Koch, Stefan, Adamini, Nico, Minner, Sarah, Simon, Ronald, Sauter, Guido, Weischenfeldt, Joachim, Klatte, Tobias, Schlomm, Thorsten, Horst, David, Zecha, Henrik

“…Objective There is a shortage of established prognostic biomarkers in bladder cancer. One candidate is tumour protein 63 (p63), a transcription factor of the…”
Get full text

The miRNA-kallikrein axis of interaction: a new dimension in the pathogenesis of prostate cancer by White, Nicole M A, Youssef, Youssef M, Fendler, Annika, Stephan, Carsten, Jung, Klaus, Yousef, George M

“…Kallikrein-related peptidases (KLKs) are a family of serine proteases that were shown to be useful cancer biomarkers. KLKs have been shown to be dysregulated…”
Get more information

Patient-derived Models: A Promising Frontier in Testing the Efficacy of Drugs for Bladder Cancer by Plage, Henning, Dressler, Franz F., Fendler, Annika

Get full text

The translational potential of microRNAs as biofluid markers of urological tumours by Fendler, Annika, Stephan, Carsten, Yousef, George M., Kristiansen, Glen, Jung, Klaus

“…Key Points Several hundred microRNAs (miRNAs) occur in biofluids as free molecules or are secreted in vesicles or bound in a ribonucleoprotein complex The…”
Get full text

Cancer, COVID-19, and Antiviral Immunity: The CAPTURE Study by Au, Lewis, Boos, Laura Amanda, Swerdlow, Anthony, Byrne, Fiona, Shepherd, Scott T.C., Fendler, Annika, Turajlic, Samra

“…The SARS-CoV-2 pandemic has posed a significant challenge for risk evaluation and mitigation among cancer patients. Susceptibility to and severity of COVID-19…”
Get full text

Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas by Busch, Jonas, Ralla, Bernhard, Jung, Monika, Wotschofsky, Zofia, Trujillo-Arribas, Elena, Schwabe, Philipp, Kilic, Ergin, Fendler, Annika, Jung, Klaus

“…Piwi-interacting RNAs (piRNAs) are small RNAs of 27-30 nucleotides mapping to transposons or clustering in repeat genomic regions. Preliminary studies suggest…”
Get full text

Circular RNAs: a new class of biomarkers as a rising interest in laboratory medicine by Franz, Antonia, Rabien, Anja, Stephan, Carsten, Ralla, Bernhard, Fuchs, Steffen, Jung, Klaus, Fendler, Annika

“…Circular RNAs (circRNAs) are a distinct family of RNAs derived from the non-regular process of alternative splicing. CircRNAs have recently gained interest in…”
Get more information

MicroRNAs as new diagnostic and prognostic biomarkers in urological tumors by Fendler, Annika, Jung, Klaus

“…MicroRNAs are single-stranded regulatory molecules that play an important role during carcinogenesis. Since microRNA expressions are deregulated in cancer and…”
Get more information